Theoretical and experimental study of electroporation of red blood cells using MEMS technology

Handle URI:
http://hdl.handle.net/10754/600265
Title:
Theoretical and experimental study of electroporation of red blood cells using MEMS technology
Authors:
Deng, Peigang; Yin, Guangyao; Zhang, Tong Yi; Chang, Donald C.; Lee, Yi Kuen
Abstract:
A theoretical and experimental study of electroporation (EP) of red blood cells (RBCs) was presented in this paper. With additional strain energy, an energy-based model of an electropore induced on a RBC's membrane at different electric fields was proposed to predict the critical EP electric field strength. In addition, EP experiments with red blood cells at single-cell level was carried out on a micro EP chip. The measured critical EP electric field strengths are in agreement with the numerical predictions. ©2010 IEEE.
Citation:
Peigang Deng, Guangyao Yin, Tong-Yi Zhang, Chang DC, Yi-Kuen Lee (2010) Theoretical and experimental study of electroporation of red blood cells using MEMS technology. 2010 IEEE 5th International Conference on Nano/Micro Engineered and Molecular Systems. Available: http://dx.doi.org/10.1109/nems.2010.5592472.
Publisher:
Institute of Electrical and Electronics Engineers (IEEE)
Journal:
2010 IEEE 5th International Conference on Nano/Micro Engineered and Molecular Systems
KAUST Grant Number:
SA-C0040; UK-C0016
Conference/Event name:
5th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2010
Issue Date:
Jan-2010
DOI:
10.1109/nems.2010.5592472
Type:
Conference Paper
ISBN:
9781424465439
Sponsors:
This research was partially supported by a Hong Kong RGC grant (No. 615907) and by an award from King Abdullah University of Science and Technology (KAUST Award No. SA-C0040/UK-C0016).
Appears in Collections:
Publications Acknowledging KAUST Support

Full metadata record

DC FieldValue Language
dc.contributor.authorDeng, Peigangen
dc.contributor.authorYin, Guangyaoen
dc.contributor.authorZhang, Tong Yien
dc.contributor.authorChang, Donald C.en
dc.contributor.authorLee, Yi Kuenen
dc.date.accessioned2016-02-28T08:00:18Zen
dc.date.available2016-02-28T08:00:18Zen
dc.date.issued2010-01en
dc.identifier.citationPeigang Deng, Guangyao Yin, Tong-Yi Zhang, Chang DC, Yi-Kuen Lee (2010) Theoretical and experimental study of electroporation of red blood cells using MEMS technology. 2010 IEEE 5th International Conference on Nano/Micro Engineered and Molecular Systems. Available: http://dx.doi.org/10.1109/nems.2010.5592472.en
dc.identifier.isbn9781424465439en
dc.identifier.doi10.1109/nems.2010.5592472en
dc.identifier.urihttp://hdl.handle.net/10754/600265en
dc.description.abstractA theoretical and experimental study of electroporation (EP) of red blood cells (RBCs) was presented in this paper. With additional strain energy, an energy-based model of an electropore induced on a RBC's membrane at different electric fields was proposed to predict the critical EP electric field strength. In addition, EP experiments with red blood cells at single-cell level was carried out on a micro EP chip. The measured critical EP electric field strengths are in agreement with the numerical predictions. ©2010 IEEE.en
dc.description.sponsorshipThis research was partially supported by a Hong Kong RGC grant (No. 615907) and by an award from King Abdullah University of Science and Technology (KAUST Award No. SA-C0040/UK-C0016).en
dc.publisherInstitute of Electrical and Electronics Engineers (IEEE)en
dc.subjectElectroporationen
dc.subjectMicro electroporation chipen
dc.subjectRed blood cellen
dc.subjectStrain energyen
dc.titleTheoretical and experimental study of electroporation of red blood cells using MEMS technologyen
dc.typeConference Paperen
dc.identifier.journal2010 IEEE 5th International Conference on Nano/Micro Engineered and Molecular Systemsen
dc.conference.date20 January 2010 through 23 January 2010en
dc.conference.name5th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2010en
dc.conference.locationXiamenen
dc.contributor.institutionBioengineering Graduate Program, Hong Kong University of Science and Technology, Hong Kong, Hong Kongen
dc.contributor.institutionDept. of Mechanical Engineering, Hong Kong University of Science and Technology, Hong Kong, Hong Kongen
dc.contributor.institutionDept. of Biology, Hong Kong University of Science and Technology, Hong Kong, Hong Kongen
kaust.authorPeigang Deng,en
kaust.grant.numberSA-C0040en
kaust.grant.numberUK-C0016en
kaust.grant.fundedcenterKAUST-HKUST Micro/Nanofluidic Joint Laboratoryen
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