Aspergilones A and B, two benzylazaphilones with an unprecedented carbon skeleton from the gorgonian-derived fungus Aspergillus sp.

Handle URI:
http://hdl.handle.net/10754/600226
Title:
Aspergilones A and B, two benzylazaphilones with an unprecedented carbon skeleton from the gorgonian-derived fungus Aspergillus sp.
Authors:
Shao, Chang Lun; Wang, Chang Yun; Wei, Mei Yan; Gu, Yu Cheng; She, Zhi Gang; Qian, Pei Yuan; Lin, Yong Cheng
Abstract:
Two novel benzylazaphilone derivatives with an unprecedented carbon skeleton, aspergilone A (1), and its symmetrical dimer with a unique methylene bridge, aspergilone B (2), have been isolated from the culture broth of a marine-derived fungus Aspergillus sp. from a gorgonian Dichotella gemmacea. Their structures and relative stereochemistries of 1 and 2 were elucidated using a combination of NMR spectroscopy and X-ray crystallography. Compound 1 not only exhibited in vitro selective cytotoxicity but also showed potent antifouling activity. © 2010 Elsevier Ltd. All rights reserved.
Citation:
Shao C-L, Wang C-Y, Wei M-Y, Gu Y-C, She Z-G, et al. (2011) Aspergilones A and B, two benzylazaphilones with an unprecedented carbon skeleton from the gorgonian-derived fungus Aspergillus sp. Bioorganic & Medicinal Chemistry Letters 21: 690–693. Available: http://dx.doi.org/10.1016/j.bmcl.2010.12.005.
Publisher:
Elsevier BV
Journal:
Bioorganic & Medicinal Chemistry Letters
Issue Date:
Jan-2011
DOI:
10.1016/j.bmcl.2010.12.005
PubMed ID:
21194945
Type:
Article
ISSN:
0960-894X
Sponsors:
This work was supported by the National Natural Science Foundation of China (Nos. 30901879; 40976077; 40776073), the Research Fund for the Doctoral Program of Higher Education, Ministry of Education of China (No. 20090132110002), and the Basic Research Program of Science and Technology, Ministry of Science and Technology of China (No. 2007FY210500).
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Full metadata record

DC FieldValue Language
dc.contributor.authorShao, Chang Lunen
dc.contributor.authorWang, Chang Yunen
dc.contributor.authorWei, Mei Yanen
dc.contributor.authorGu, Yu Chengen
dc.contributor.authorShe, Zhi Gangen
dc.contributor.authorQian, Pei Yuanen
dc.contributor.authorLin, Yong Chengen
dc.date.accessioned2016-02-28T07:59:28Zen
dc.date.available2016-02-28T07:59:28Zen
dc.date.issued2011-01en
dc.identifier.citationShao C-L, Wang C-Y, Wei M-Y, Gu Y-C, She Z-G, et al. (2011) Aspergilones A and B, two benzylazaphilones with an unprecedented carbon skeleton from the gorgonian-derived fungus Aspergillus sp. Bioorganic & Medicinal Chemistry Letters 21: 690–693. Available: http://dx.doi.org/10.1016/j.bmcl.2010.12.005.en
dc.identifier.issn0960-894Xen
dc.identifier.pmid21194945en
dc.identifier.doi10.1016/j.bmcl.2010.12.005en
dc.identifier.urihttp://hdl.handle.net/10754/600226en
dc.description.abstractTwo novel benzylazaphilone derivatives with an unprecedented carbon skeleton, aspergilone A (1), and its symmetrical dimer with a unique methylene bridge, aspergilone B (2), have been isolated from the culture broth of a marine-derived fungus Aspergillus sp. from a gorgonian Dichotella gemmacea. Their structures and relative stereochemistries of 1 and 2 were elucidated using a combination of NMR spectroscopy and X-ray crystallography. Compound 1 not only exhibited in vitro selective cytotoxicity but also showed potent antifouling activity. © 2010 Elsevier Ltd. All rights reserved.en
dc.description.sponsorshipThis work was supported by the National Natural Science Foundation of China (Nos. 30901879; 40976077; 40776073), the Research Fund for the Doctoral Program of Higher Education, Ministry of Education of China (No. 20090132110002), and the Basic Research Program of Science and Technology, Ministry of Science and Technology of China (No. 2007FY210500).en
dc.publisherElsevier BVen
dc.subjectAntifouling activityen
dc.subjectAspergillus sp.en
dc.subjectAspergiloneen
dc.subjectCytotoxicityen
dc.subjectGorgonian Dichotella gemmaceaen
dc.subjectMarine-derived fungusen
dc.subjectX-ray analysisen
dc.titleAspergilones A and B, two benzylazaphilones with an unprecedented carbon skeleton from the gorgonian-derived fungus Aspergillus sp.en
dc.typeArticleen
dc.identifier.journalBioorganic & Medicinal Chemistry Lettersen
dc.contributor.institutionKey Laboratory of Marine Drugs, Ocean University of China, Ministry of Education of China, Qingdao 266003, Chinaen
dc.contributor.institutionSchool of Pharmacy, Guangdong Medical College, Dongguan 523808, Chinaen
dc.contributor.institutionSyngenta, Jealott's Hill International Research Centre, Bracknell, Berkshire RG42 6EY, United Kingdomen
dc.contributor.institutionSchool of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, Chinaen
kaust.authorQian, Pei-Yuanen
kaust.grant.programKAUST Global Partnership Programen

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