Antifouling briarane type diterpenoids from South China Sea gorgonians Dichotella gemmacea

Handle URI:
http://hdl.handle.net/10754/600225
Title:
Antifouling briarane type diterpenoids from South China Sea gorgonians Dichotella gemmacea
Authors:
Sun, Jian Fan; Han, Zhuang; Zhou, Xue Feng; Yang, Bin; Lin, Xiuping; Liu, Juan; Peng, Yan; Yang, Xian Wen; Liu, Yonghong
Abstract:
Our continued investigation on the South China Sea gorgonian Dichotella gemmacea led to the isolation of 16 new briarane-type diterpenoids, dichotellides F-U (1-16), along with 18 known analogues (17-34). Their structures were determined by MS, 1D and 2D NMR spectra analyses and by comparison with those reported in literature. The absolute configuration of 15 was confirmed by single-crystal X-ray diffraction data. The antifouling test showed that compounds 3, 4, 6-11, 16, and 23 had potent antifouling activities at nontoxic concentrations with EC50 values of 4.1, 1.82, 6.3, 7.6, 4.6, 1.2, 5.6, 0.79, 2.0, and 0.2 μg/mL, respectively. © 2012 Elsevier Ltd. All rights reserved.
Citation:
Sun J-F, Han Z, Zhou X-F, Yang B, Lin X, et al. (2013) Antifouling briarane type diterpenoids from South China Sea gorgonians Dichotella gemmacea. Tetrahedron 69: 871–880. Available: http://dx.doi.org/10.1016/j.tet.2012.10.102.
Publisher:
Elsevier BV
Journal:
Tetrahedron
Issue Date:
Jan-2013
DOI:
10.1016/j.tet.2012.10.102
Type:
Article
ISSN:
0040-4020
Sponsors:
This study was supported by the National Basic Research Program of China (973 Program, Nos. 2010CB833800 and 2011CB915503), the National High Technology Research and Development Program (863 Program, 2012AA092104), Knowledge Innovation Program of Chinese Academy of Science (KSCX2-YW-G-073 and KSCX2-EW-G-12B), and National Natural Science Foundation of China (Nos. 30973679, 20902094, 21172230, 41176148, 21002110).Guangdong Province-CAS Joint Research Program (2011B0 90300023), Guangdong Province Marine and Fishery Special Project for Science and Technology Popularization (A201101F03), the start-up grant from Jiangsu University (11JDG1147).
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Full metadata record

DC FieldValue Language
dc.contributor.authorSun, Jian Fanen
dc.contributor.authorHan, Zhuangen
dc.contributor.authorZhou, Xue Fengen
dc.contributor.authorYang, Binen
dc.contributor.authorLin, Xiupingen
dc.contributor.authorLiu, Juanen
dc.contributor.authorPeng, Yanen
dc.contributor.authorYang, Xian Wenen
dc.contributor.authorLiu, Yonghongen
dc.date.accessioned2016-02-28T07:59:26Zen
dc.date.available2016-02-28T07:59:26Zen
dc.date.issued2013-01en
dc.identifier.citationSun J-F, Han Z, Zhou X-F, Yang B, Lin X, et al. (2013) Antifouling briarane type diterpenoids from South China Sea gorgonians Dichotella gemmacea. Tetrahedron 69: 871–880. Available: http://dx.doi.org/10.1016/j.tet.2012.10.102.en
dc.identifier.issn0040-4020en
dc.identifier.doi10.1016/j.tet.2012.10.102en
dc.identifier.urihttp://hdl.handle.net/10754/600225en
dc.description.abstractOur continued investigation on the South China Sea gorgonian Dichotella gemmacea led to the isolation of 16 new briarane-type diterpenoids, dichotellides F-U (1-16), along with 18 known analogues (17-34). Their structures were determined by MS, 1D and 2D NMR spectra analyses and by comparison with those reported in literature. The absolute configuration of 15 was confirmed by single-crystal X-ray diffraction data. The antifouling test showed that compounds 3, 4, 6-11, 16, and 23 had potent antifouling activities at nontoxic concentrations with EC50 values of 4.1, 1.82, 6.3, 7.6, 4.6, 1.2, 5.6, 0.79, 2.0, and 0.2 μg/mL, respectively. © 2012 Elsevier Ltd. All rights reserved.en
dc.description.sponsorshipThis study was supported by the National Basic Research Program of China (973 Program, Nos. 2010CB833800 and 2011CB915503), the National High Technology Research and Development Program (863 Program, 2012AA092104), Knowledge Innovation Program of Chinese Academy of Science (KSCX2-YW-G-073 and KSCX2-EW-G-12B), and National Natural Science Foundation of China (Nos. 30973679, 20902094, 21172230, 41176148, 21002110).Guangdong Province-CAS Joint Research Program (2011B0 90300023), Guangdong Province Marine and Fishery Special Project for Science and Technology Popularization (A201101F03), the start-up grant from Jiangsu University (11JDG1147).en
dc.publisherElsevier BVen
dc.subjectAntifouling agentsen
dc.subjectDichotella gemmaceaen
dc.subjectDiterpenoidsen
dc.subjectNatural productsen
dc.subjectNontoxicen
dc.subjectStructure elucidationen
dc.titleAntifouling briarane type diterpenoids from South China Sea gorgonians Dichotella gemmaceaen
dc.typeArticleen
dc.identifier.journalTetrahedronen
dc.contributor.institutionKey Laboratory of Marine Bio-resources Sustainable Utilization, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, Chinaen
dc.contributor.institutionSchool of Environment, Jiangsu University, Zhenjiang 212013, Chinaen
kaust.authorHan, Zhuangen
kaust.grant.programKAUST Global Partnership Programen
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