Antifouling Activity of Secondary Metabolites Isolated from Chinese Marine Organisms

Handle URI:
http://hdl.handle.net/10754/600215
Title:
Antifouling Activity of Secondary Metabolites Isolated from Chinese Marine Organisms
Authors:
Li, Yong Xin; Wu, Hui Xian; Xu, Ying; Shao, Chang Lun; Wang, Chang Yun; Qian, Pei Yuan
Abstract:
Biofouling results in tremendous economic losses to maritime industries around the world. A recent global ban on the use of organotin compounds as antifouling agents has further raised demand for safe and effective antifouling compounds. In this study, 49 secondary metabolites, including diterpenoids, steroids, and polyketides, were isolated from soft corals, gorgonians, brown algae, and fungi collected along the coast of China, and their antifouling activity was tested against cyprids of the barnacle Balanus (Amphibalanus) amphitrite. Twenty of the compounds were found to inhibit larval settlement significantly at a concentration of 25 μg ml-1. Two briarane diterpenoids, juncin O (2) and juncenolide H (3), were the most promising non-toxic antilarval settlement candidates, with EC50 values less than 0.13 μg ml-1 and a safety ratio (LC50/EC50) higher than 400. A preliminary structure-activity relationships study indicated that both furanon and furan moieties are important for antifouling activity. Intriguingly, the presence of hydroxyls enhanced their antisettlement activity. © 2013 Springer Science+Business Media New York.
Citation:
Li Y-X, Wu H-X, Xu Y, Shao C-L, Wang C-Y, et al. (2013) Antifouling Activity of Secondary Metabolites Isolated from Chinese Marine Organisms. Mar Biotechnol 15: 552–558. Available: http://dx.doi.org/10.1007/s10126-013-9502-7.
Publisher:
Springer Nature
Journal:
Marine Biotechnology
KAUST Grant Number:
SA-C0040; UK-C001
Issue Date:
25-Apr-2013
DOI:
10.1007/s10126-013-9502-7
PubMed ID:
23613141
Type:
Article
ISSN:
1436-2228; 1436-2236
Sponsors:
This study was supported by a research grant (DY125-15-T-02) from the China Ocean Mineral Resources Research and Development Association, a joint research grant from the Research Grants Council of the Hong Kong Special Administrative Region and the National Natural Science Foundation of China (N_HKUST602/09 and No. 41130858), and an award (SA-C0040/UK-C001) from King Abdullah University of Science and Technology (KAUST) granted to P.Y. Qian.
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Full metadata record

DC FieldValue Language
dc.contributor.authorLi, Yong Xinen
dc.contributor.authorWu, Hui Xianen
dc.contributor.authorXu, Yingen
dc.contributor.authorShao, Chang Lunen
dc.contributor.authorWang, Chang Yunen
dc.contributor.authorQian, Pei Yuanen
dc.date.accessioned2016-02-28T07:59:12Zen
dc.date.available2016-02-28T07:59:12Zen
dc.date.issued2013-04-25en
dc.identifier.citationLi Y-X, Wu H-X, Xu Y, Shao C-L, Wang C-Y, et al. (2013) Antifouling Activity of Secondary Metabolites Isolated from Chinese Marine Organisms. Mar Biotechnol 15: 552–558. Available: http://dx.doi.org/10.1007/s10126-013-9502-7.en
dc.identifier.issn1436-2228en
dc.identifier.issn1436-2236en
dc.identifier.pmid23613141en
dc.identifier.doi10.1007/s10126-013-9502-7en
dc.identifier.urihttp://hdl.handle.net/10754/600215en
dc.description.abstractBiofouling results in tremendous economic losses to maritime industries around the world. A recent global ban on the use of organotin compounds as antifouling agents has further raised demand for safe and effective antifouling compounds. In this study, 49 secondary metabolites, including diterpenoids, steroids, and polyketides, were isolated from soft corals, gorgonians, brown algae, and fungi collected along the coast of China, and their antifouling activity was tested against cyprids of the barnacle Balanus (Amphibalanus) amphitrite. Twenty of the compounds were found to inhibit larval settlement significantly at a concentration of 25 μg ml-1. Two briarane diterpenoids, juncin O (2) and juncenolide H (3), were the most promising non-toxic antilarval settlement candidates, with EC50 values less than 0.13 μg ml-1 and a safety ratio (LC50/EC50) higher than 400. A preliminary structure-activity relationships study indicated that both furanon and furan moieties are important for antifouling activity. Intriguingly, the presence of hydroxyls enhanced their antisettlement activity. © 2013 Springer Science+Business Media New York.en
dc.description.sponsorshipThis study was supported by a research grant (DY125-15-T-02) from the China Ocean Mineral Resources Research and Development Association, a joint research grant from the Research Grants Council of the Hong Kong Special Administrative Region and the National Natural Science Foundation of China (N_HKUST602/09 and No. 41130858), and an award (SA-C0040/UK-C001) from King Abdullah University of Science and Technology (KAUST) granted to P.Y. Qian.en
dc.publisherSpringer Natureen
dc.subjectAntifoulingen
dc.subjectAntilarval settlementen
dc.subjectBalanus amphitriteen
dc.subjectMarine natural productsen
dc.subjectStructure-activity relationshipen
dc.titleAntifouling Activity of Secondary Metabolites Isolated from Chinese Marine Organismsen
dc.typeArticleen
dc.identifier.journalMarine Biotechnologyen
dc.contributor.institutionCollege of Fisheries and Life Science, Shanghai Ocean University, Shanghai, Chinaen
dc.contributor.institutionKey Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao, Chinaen
kaust.authorLi, Yong-Xinen
kaust.authorWu, Hui-Xianen
kaust.authorXu, Yingen
kaust.authorQian, Pei-Yuanen
kaust.grant.numberSA-C0040en
kaust.grant.numberUK-C001en
kaust.grant.programKAUST Global Collaborative Research Programen

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