Handle URI:
http://hdl.handle.net/10754/600012
Title:
Three mechanical models for blebbing and multi-blebbing
Authors:
Woolley, T. E.; Gaffney, E. A.; Waters, S. L.; Oliver, J. M.; Baker, R. E.; Goriely, A.
Abstract:
Membrane protrusions known as blebs play important roles in many cellular phenomena. Here we present three mathematical models of the bleb formation, which use biological insights to produce phenotypically accurate pressure-driven expansions. First, we introduce a recently suggested solid mechanics framework that is able to create blebs through stretching the membrane. This framework is then extended to include reference state reconfigurations, which models membrane growth. Finally, the stretching and reconfiguring mechanical models are compared with a much simpler geometrically constrained solution. This allows us to demonstrate that simpler systems are able to capture much of the biological complexity despite more restrictive assumptions. Moreover, the simplicity of the spherical model allows us to consider multiple blebs in a tractable framework. © 2014 The authors 2014. Published by Oxford University Press on behalf of the Institute of Mathematics and its Applications. All rights reserved.
Citation:
Woolley TE, Gaffney EA, Waters SL, Oliver JM, Baker RE, et al. (2014) Three mechanical models for blebbing and multi-blebbing. IMA Journal of Applied Mathematics 79: 636–660. Available: http://dx.doi.org/10.1093/imamat/hxu028.
Publisher:
Oxford University Press (OUP)
Journal:
IMA Journal of Applied Mathematics
KAUST Grant Number:
KUK-C1-013-04
Issue Date:
17-Jun-2014
DOI:
10.1093/imamat/hxu028
Type:
Article
ISSN:
0272-4960; 1464-3634
Sponsors:
This publication is based on work supported by Award No. KUK-C1-013-04, made by King Abdullah University of Science and Technology (KAUST).
Appears in Collections:
Publications Acknowledging KAUST Support

Full metadata record

DC FieldValue Language
dc.contributor.authorWoolley, T. E.en
dc.contributor.authorGaffney, E. A.en
dc.contributor.authorWaters, S. L.en
dc.contributor.authorOliver, J. M.en
dc.contributor.authorBaker, R. E.en
dc.contributor.authorGoriely, A.en
dc.date.accessioned2016-02-28T06:34:20Zen
dc.date.available2016-02-28T06:34:20Zen
dc.date.issued2014-06-17en
dc.identifier.citationWoolley TE, Gaffney EA, Waters SL, Oliver JM, Baker RE, et al. (2014) Three mechanical models for blebbing and multi-blebbing. IMA Journal of Applied Mathematics 79: 636–660. Available: http://dx.doi.org/10.1093/imamat/hxu028.en
dc.identifier.issn0272-4960en
dc.identifier.issn1464-3634en
dc.identifier.doi10.1093/imamat/hxu028en
dc.identifier.urihttp://hdl.handle.net/10754/600012en
dc.description.abstractMembrane protrusions known as blebs play important roles in many cellular phenomena. Here we present three mathematical models of the bleb formation, which use biological insights to produce phenotypically accurate pressure-driven expansions. First, we introduce a recently suggested solid mechanics framework that is able to create blebs through stretching the membrane. This framework is then extended to include reference state reconfigurations, which models membrane growth. Finally, the stretching and reconfiguring mechanical models are compared with a much simpler geometrically constrained solution. This allows us to demonstrate that simpler systems are able to capture much of the biological complexity despite more restrictive assumptions. Moreover, the simplicity of the spherical model allows us to consider multiple blebs in a tractable framework. © 2014 The authors 2014. Published by Oxford University Press on behalf of the Institute of Mathematics and its Applications. All rights reserved.en
dc.description.sponsorshipThis publication is based on work supported by Award No. KUK-C1-013-04, made by King Abdullah University of Science and Technology (KAUST).en
dc.publisherOxford University Press (OUP)en
dc.subjectbleben
dc.subjectcellular motionen
dc.subjectsemi-inverse problemen
dc.subjectsolid mechanicsen
dc.titleThree mechanical models for blebbing and multi-blebbingen
dc.typeArticleen
dc.identifier.journalIMA Journal of Applied Mathematicsen
dc.contributor.institutionUniversity of Oxford, Oxford, United Kingdomen
kaust.grant.numberKUK-C1-013-04en
All Items in KAUST are protected by copyright, with all rights reserved, unless otherwise indicated.