Theory for the alignment of cortical feature maps during development

Handle URI:
http://hdl.handle.net/10754/599985
Title:
Theory for the alignment of cortical feature maps during development
Authors:
Bressloff, Paul C.; Oster, Andrew M.
Abstract:
We present a developmental model of ocular dominance column formation that takes into account the existence of an array of intrinsically specified cytochrome oxidase blobs. We assume that there is some molecular substrate for the blobs early in development, which generates a spatially periodic modulation of experience-dependent plasticity. We determine the effects of such a modulation on a competitive Hebbian mechanism for the modification of the feedforward afferents from the left and right eyes. We show how alternating left and right eye dominated columns can develop, in which the blobs are aligned with the centers of the ocular dominance columns and receive a greater density of feedforward connections, thus becoming defined extrinsically. More generally, our results suggest that the presence of periodically distributed anatomical markers early in development could provide a mechanism for the alignment of cortical feature maps. © 2010 The American Physical Society.
Citation:
Bressloff PC, Oster AM (2010) Theory for the alignment of cortical feature maps during development. Phys Rev E 82. Available: http://dx.doi.org/10.1103/PhysRevE.82.021920.
Publisher:
American Physical Society (APS)
Journal:
Physical Review E
KAUST Grant Number:
KUK-C1-013-4
Issue Date:
23-Aug-2010
DOI:
10.1103/PhysRevE.82.021920
PubMed ID:
20866850
Type:
Article
ISSN:
1539-3755; 1550-2376
Sponsors:
This paper was based on work supported in part by the NSF (Grant No. DMS-0209824) and by Award No. KUK-C1-013-4 made by the King Abdullah University of Science and Technology (KAUST). P.C.B. was also partially supported by the Royal Society-Wolfson Foundation, and A.M.O. was partially supported by the Neuropole de Recherche Francilien (NeRF) and an ANR MNP 'Dopanic' grant.
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Full metadata record

DC FieldValue Language
dc.contributor.authorBressloff, Paul C.en
dc.contributor.authorOster, Andrew M.en
dc.date.accessioned2016-02-28T06:33:49Zen
dc.date.available2016-02-28T06:33:49Zen
dc.date.issued2010-08-23en
dc.identifier.citationBressloff PC, Oster AM (2010) Theory for the alignment of cortical feature maps during development. Phys Rev E 82. Available: http://dx.doi.org/10.1103/PhysRevE.82.021920.en
dc.identifier.issn1539-3755en
dc.identifier.issn1550-2376en
dc.identifier.pmid20866850en
dc.identifier.doi10.1103/PhysRevE.82.021920en
dc.identifier.urihttp://hdl.handle.net/10754/599985en
dc.description.abstractWe present a developmental model of ocular dominance column formation that takes into account the existence of an array of intrinsically specified cytochrome oxidase blobs. We assume that there is some molecular substrate for the blobs early in development, which generates a spatially periodic modulation of experience-dependent plasticity. We determine the effects of such a modulation on a competitive Hebbian mechanism for the modification of the feedforward afferents from the left and right eyes. We show how alternating left and right eye dominated columns can develop, in which the blobs are aligned with the centers of the ocular dominance columns and receive a greater density of feedforward connections, thus becoming defined extrinsically. More generally, our results suggest that the presence of periodically distributed anatomical markers early in development could provide a mechanism for the alignment of cortical feature maps. © 2010 The American Physical Society.en
dc.description.sponsorshipThis paper was based on work supported in part by the NSF (Grant No. DMS-0209824) and by Award No. KUK-C1-013-4 made by the King Abdullah University of Science and Technology (KAUST). P.C.B. was also partially supported by the Royal Society-Wolfson Foundation, and A.M.O. was partially supported by the Neuropole de Recherche Francilien (NeRF) and an ANR MNP 'Dopanic' grant.en
dc.publisherAmerican Physical Society (APS)en
dc.titleTheory for the alignment of cortical feature maps during developmenten
dc.typeArticleen
dc.identifier.journalPhysical Review Een
dc.contributor.institutionUniversity of Oxford, Oxford, United Kingdomen
dc.contributor.institutionUniversity of Utah, Salt Lake City, United Statesen
dc.contributor.institutionEcole Normale Superieure, Paris, Franceen
kaust.grant.numberKUK-C1-013-4en

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