The role of auxin and cytokinin signalling in specifying the root architecture of Arabidopsis thaliana

Handle URI:
http://hdl.handle.net/10754/599955
Title:
The role of auxin and cytokinin signalling in specifying the root architecture of Arabidopsis thaliana
Authors:
Muraro, Daniele; Byrne, Helen; King, John; Bennett, Malcolm
Abstract:
Auxin and cytokinin are key hormonal signals that control the cellular architecture of the primary root and the initiation of new lateral root organs in the plant Arabidopsis thaliana. Both developmental processes are regulated by cross-talk between these hormones and their signalling pathways. In this paper, sub-cellular and multi-cellular mathematical models are developed to investigate how interactions between auxin and cytokinin influence the size and location of regions of division and differentiation within the primary root, and describe how their cross-regulation may cause periodic branching of lateral roots. We show how their joint activity may influence tissue-specific oscillations in gene expression, as shown in Moreno-Risueno et al. (2010) and commented upon in Traas and Vernoux (2010), and we propose mechanisms that may generate synchronisation of such periodic behaviours inside a cell and with its neighbours. Using a multi-cellular model, we also analyse the roles of cytokinin and auxin in specifying the three main regions of the primary root (elongation, transition and division zones), our simulation results being in good agreement with independent experimental observations. We then use our model to generate testable predictions concerning the effect of varying the concentrations of the auxin efflux transporters on the sizes of the different root regions. In particular, we predict that over-expression of the transporters will generate a longer root with a longer elongation zone and a smaller division zone than that of a wild type root. This root will contain fewer cells than its wild type counterpart. We conclude that our model can provide a useful tool for investigating the response of cell division and elongation to perturbations in hormonal signalling. © 2012 Elsevier Ltd.
Citation:
Muraro D, Byrne H, King J, Bennett M (2013) The role of auxin and cytokinin signalling in specifying the root architecture of Arabidopsis thaliana. Journal of Theoretical Biology 317: 71–86. Available: http://dx.doi.org/10.1016/j.jtbi.2012.08.032.
Publisher:
Elsevier BV
Journal:
Journal of Theoretical Biology
KAUST Grant Number:
KUK-013-04
Issue Date:
Jan-2013
DOI:
10.1016/j.jtbi.2012.08.032
PubMed ID:
23026765
Type:
Article
ISSN:
0022-5193
Sponsors:
We gratefully acknowledge the Biotechnology and Biological Research Council and the Engineering and Sciences Research Council for financial support as part of the CISB programme award to CPIB. J.R. King also gratefully acknowledges the funding of the Royal Society and Wolfson Foundation. The work of the second author was supported in part by Award No. KUK-013-04, made by King Abdullah University of Science and Technology (KAUST). The authors also thank anonymous referees for constructive criticisms.
Appears in Collections:
Publications Acknowledging KAUST Support

Full metadata record

DC FieldValue Language
dc.contributor.authorMuraro, Danieleen
dc.contributor.authorByrne, Helenen
dc.contributor.authorKing, Johnen
dc.contributor.authorBennett, Malcolmen
dc.date.accessioned2016-02-28T06:33:12Zen
dc.date.available2016-02-28T06:33:12Zen
dc.date.issued2013-01en
dc.identifier.citationMuraro D, Byrne H, King J, Bennett M (2013) The role of auxin and cytokinin signalling in specifying the root architecture of Arabidopsis thaliana. Journal of Theoretical Biology 317: 71–86. Available: http://dx.doi.org/10.1016/j.jtbi.2012.08.032.en
dc.identifier.issn0022-5193en
dc.identifier.pmid23026765en
dc.identifier.doi10.1016/j.jtbi.2012.08.032en
dc.identifier.urihttp://hdl.handle.net/10754/599955en
dc.description.abstractAuxin and cytokinin are key hormonal signals that control the cellular architecture of the primary root and the initiation of new lateral root organs in the plant Arabidopsis thaliana. Both developmental processes are regulated by cross-talk between these hormones and their signalling pathways. In this paper, sub-cellular and multi-cellular mathematical models are developed to investigate how interactions between auxin and cytokinin influence the size and location of regions of division and differentiation within the primary root, and describe how their cross-regulation may cause periodic branching of lateral roots. We show how their joint activity may influence tissue-specific oscillations in gene expression, as shown in Moreno-Risueno et al. (2010) and commented upon in Traas and Vernoux (2010), and we propose mechanisms that may generate synchronisation of such periodic behaviours inside a cell and with its neighbours. Using a multi-cellular model, we also analyse the roles of cytokinin and auxin in specifying the three main regions of the primary root (elongation, transition and division zones), our simulation results being in good agreement with independent experimental observations. We then use our model to generate testable predictions concerning the effect of varying the concentrations of the auxin efflux transporters on the sizes of the different root regions. In particular, we predict that over-expression of the transporters will generate a longer root with a longer elongation zone and a smaller division zone than that of a wild type root. This root will contain fewer cells than its wild type counterpart. We conclude that our model can provide a useful tool for investigating the response of cell division and elongation to perturbations in hormonal signalling. © 2012 Elsevier Ltd.en
dc.description.sponsorshipWe gratefully acknowledge the Biotechnology and Biological Research Council and the Engineering and Sciences Research Council for financial support as part of the CISB programme award to CPIB. J.R. King also gratefully acknowledges the funding of the Royal Society and Wolfson Foundation. The work of the second author was supported in part by Award No. KUK-013-04, made by King Abdullah University of Science and Technology (KAUST). The authors also thank anonymous referees for constructive criticisms.en
dc.publisherElsevier BVen
dc.subjectCytokinin-auxin cross-regulationen
dc.subjectLateral root developmenten
dc.subjectMathematical modellingen
dc.titleThe role of auxin and cytokinin signalling in specifying the root architecture of Arabidopsis thalianaen
dc.typeArticleen
dc.identifier.journalJournal of Theoretical Biologyen
dc.contributor.institutionUniversity of Nottingham, Nottingham, United Kingdomen
dc.contributor.institutionUniversity of Oxford, Oxford, United Kingdomen
kaust.grant.numberKUK-013-04en

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