The effect of the signalling scheme on the robustness of pattern formation in development

Handle URI:
http://hdl.handle.net/10754/599906
Title:
The effect of the signalling scheme on the robustness of pattern formation in development
Authors:
Kang, H.-W.; Zheng, L.; Othmer, H. G.
Abstract:
Pattern formation in development is a complex process which involves spatially distributed signals called morphogens that influence gene expression and thus the phenotypic identity of cells. Usually different cell types are spatially segregated, and the boundary between them may be determined by a threshold value of some state variable. The question arises as to how sensitive the location of such a boundary is to variations in properties, such as parameter values, that characterize the system. Here, we analyse both deterministic and stochastic reaction-diffusion models of pattern formation with a view towards understanding how the signalling scheme used for patterning affects the variability of boundary determination between cell types in a developing tissue.
Citation:
Kang H-W, Zheng L, Othmer HG (2012) The effect of the signalling scheme on the robustness of pattern formation in development. Interface Focus 2: 465–486. Available: http://dx.doi.org/10.1098/rsfs.2011.0116.
Publisher:
The Royal Society
Journal:
Interface Focus
KAUST Grant Number:
KUK-C1-013-04
Issue Date:
21-Mar-2012
DOI:
10.1098/rsfs.2011.0116
PubMed ID:
22649582
PubMed Central ID:
PMC3363034
Type:
Article
ISSN:
2042-8898; 2042-8901
Sponsors:
This publication was based on work supported in part by NIH grant no. GM29123 and in part by award no. KUK-C1-013-04, made by the King Abdullah University of Science and Technology (KAUST), and by the Mathematical Biosciences Institute.
Appears in Collections:
Publications Acknowledging KAUST Support

Full metadata record

DC FieldValue Language
dc.contributor.authorKang, H.-W.en
dc.contributor.authorZheng, L.en
dc.contributor.authorOthmer, H. G.en
dc.date.accessioned2016-02-28T06:32:09Zen
dc.date.available2016-02-28T06:32:09Zen
dc.date.issued2012-03-21en
dc.identifier.citationKang H-W, Zheng L, Othmer HG (2012) The effect of the signalling scheme on the robustness of pattern formation in development. Interface Focus 2: 465–486. Available: http://dx.doi.org/10.1098/rsfs.2011.0116.en
dc.identifier.issn2042-8898en
dc.identifier.issn2042-8901en
dc.identifier.pmid22649582en
dc.identifier.doi10.1098/rsfs.2011.0116en
dc.identifier.urihttp://hdl.handle.net/10754/599906en
dc.description.abstractPattern formation in development is a complex process which involves spatially distributed signals called morphogens that influence gene expression and thus the phenotypic identity of cells. Usually different cell types are spatially segregated, and the boundary between them may be determined by a threshold value of some state variable. The question arises as to how sensitive the location of such a boundary is to variations in properties, such as parameter values, that characterize the system. Here, we analyse both deterministic and stochastic reaction-diffusion models of pattern formation with a view towards understanding how the signalling scheme used for patterning affects the variability of boundary determination between cell types in a developing tissue.en
dc.description.sponsorshipThis publication was based on work supported in part by NIH grant no. GM29123 and in part by award no. KUK-C1-013-04, made by the King Abdullah University of Science and Technology (KAUST), and by the Mathematical Biosciences Institute.en
dc.publisherThe Royal Societyen
dc.subjectRobustnessen
dc.subjectpattern formationen
dc.subjectStochastic Modelsen
dc.titleThe effect of the signalling scheme on the robustness of pattern formation in developmenten
dc.typeArticleen
dc.identifier.journalInterface Focusen
dc.identifier.pmcidPMC3363034en
dc.contributor.institutionUniversity of Minnesota Twin Cities, Minneapolis, United Statesen
kaust.grant.numberKUK-C1-013-04en

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