Handle URI:
http://hdl.handle.net/10754/599905
Title:
The Effect of Polar Lipids on Tear Film Dynamics
Authors:
Aydemir, E.; Breward, C. J. W.; Witelski, T. P.
Abstract:
In this paper, we present a mathematical model describing the effect of polar lipids, excreted by glands in the eyelid and present on the surface of the tear film, on the evolution of a pre-corneal tear film. We aim to explain the interesting experimentally observed phenomenon that the tear film continues to move upward even after the upper eyelid has become stationary. The polar lipid is an insoluble surface species that locally alters the surface tension of the tear film. In the lubrication limit, the model reduces to two coupled non-linear partial differential equations for the film thickness and the concentration of lipid. We solve the system numerically and observe that increasing the concentration of the lipid increases the flow of liquid up the eye. We further exploit the size of the parameters in the problem to explain the initial evolution of the system. © 2010 Society for Mathematical Biology.
Citation:
Aydemir E, Breward CJW, Witelski TP (2010) The Effect of Polar Lipids on Tear Film Dynamics. Bull Math Biol 73: 1171–1201. Available: http://dx.doi.org/10.1007/s11538-010-9555-y.
Publisher:
Springer Nature
Journal:
Bulletin of Mathematical Biology
KAUST Grant Number:
KUK-C1-013-04
Issue Date:
17-Jun-2010
DOI:
10.1007/s11538-010-9555-y
PubMed ID:
20556530
Type:
Article
ISSN:
0092-8240; 1522-9602
Sponsors:
The authors are particularly grateful for extensive dialogue with Prof. Colin Please,useful comments by Dr. Jim Oliver, and for the support and insight provided by their experimental collab-orators, Prof. Anthony Bron and Dr. John Tiffany. This work was partly funded by an EPSRC-funded MScstudentship, is also partially based on work supported by award number KUK-C1-013-04 made by KingAbdullah University of Science and Technology and by NSF DMS CAREER grant 0239125.
Appears in Collections:
Publications Acknowledging KAUST Support

Full metadata record

DC FieldValue Language
dc.contributor.authorAydemir, E.en
dc.contributor.authorBreward, C. J. W.en
dc.contributor.authorWitelski, T. P.en
dc.date.accessioned2016-02-28T06:32:08Zen
dc.date.available2016-02-28T06:32:08Zen
dc.date.issued2010-06-17en
dc.identifier.citationAydemir E, Breward CJW, Witelski TP (2010) The Effect of Polar Lipids on Tear Film Dynamics. Bull Math Biol 73: 1171–1201. Available: http://dx.doi.org/10.1007/s11538-010-9555-y.en
dc.identifier.issn0092-8240en
dc.identifier.issn1522-9602en
dc.identifier.pmid20556530en
dc.identifier.doi10.1007/s11538-010-9555-yen
dc.identifier.urihttp://hdl.handle.net/10754/599905en
dc.description.abstractIn this paper, we present a mathematical model describing the effect of polar lipids, excreted by glands in the eyelid and present on the surface of the tear film, on the evolution of a pre-corneal tear film. We aim to explain the interesting experimentally observed phenomenon that the tear film continues to move upward even after the upper eyelid has become stationary. The polar lipid is an insoluble surface species that locally alters the surface tension of the tear film. In the lubrication limit, the model reduces to two coupled non-linear partial differential equations for the film thickness and the concentration of lipid. We solve the system numerically and observe that increasing the concentration of the lipid increases the flow of liquid up the eye. We further exploit the size of the parameters in the problem to explain the initial evolution of the system. © 2010 Society for Mathematical Biology.en
dc.description.sponsorshipThe authors are particularly grateful for extensive dialogue with Prof. Colin Please,useful comments by Dr. Jim Oliver, and for the support and insight provided by their experimental collab-orators, Prof. Anthony Bron and Dr. John Tiffany. This work was partly funded by an EPSRC-funded MScstudentship, is also partially based on work supported by award number KUK-C1-013-04 made by KingAbdullah University of Science and Technology and by NSF DMS CAREER grant 0239125.en
dc.publisherSpringer Natureen
dc.subjectBlinkingen
dc.subjectFluid mechanicsen
dc.subjectLipidsen
dc.subjectLubrication theoryen
dc.subjectTear filmsen
dc.titleThe Effect of Polar Lipids on Tear Film Dynamicsen
dc.typeArticleen
dc.identifier.journalBulletin of Mathematical Biologyen
dc.contributor.institutionUniversity of Oxford, Oxford, United Kingdomen
dc.contributor.institutionDuke University, Durham, United Statesen
kaust.grant.numberKUK-C1-013-04en

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