Tailored Poly(2-oxazoline) Polymer Brushes to Control Protein Adsorption and Cell Adhesion

Handle URI:
http://hdl.handle.net/10754/599859
Title:
Tailored Poly(2-oxazoline) Polymer Brushes to Control Protein Adsorption and Cell Adhesion
Authors:
Zhang, Ning; Pompe, Tilo; Amin, Ihsan; Luxenhofer, Robert; Werner, Carsten; Jordan, Rainer
Abstract:
POx bottle-brush brushes (BBBs) are synthesized by SIPGP of 2-isopropenyl-2-oxazoline and consecutive LCROP of 2-oxazolines on 3-aminopropyltrimethoxysilane-modified silicon substrates. The side chain hydrophilicity and polarity are varied. The impact of the chemical composition and architecture of the BBB upon protein (fibronectin) adsorption and endothelial cell adhesion are investigated and prove extremely low protein adsorption and cell adhesion on BBBs with hydrophilic side chains such as poly(2-methyl-2-oxazoline) and poly(2-ethyl-2-oxazoline). The influence of the POx side chain terminal function upon adsorption and adhesion is minor but the side chain length has a significant effect on bioadsorption. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Citation:
Zhang N, Pompe T, Amin I, Luxenhofer R, Werner C, et al. (2012) Tailored Poly(2-oxazoline) Polymer Brushes to Control Protein Adsorption and Cell Adhesion. Macromolecular Bioscience 12: 926–936. Available: http://dx.doi.org/10.1002/mabi.201200026.
Publisher:
Wiley-Blackwell
Journal:
Macromolecular Bioscience
KAUST Grant Number:
KUK-F1-029-32
Issue Date:
18-May-2012
DOI:
10.1002/mabi.201200026
PubMed ID:
22610725
Type:
Article
ISSN:
1616-5187
Sponsors:
N.Z. is thankful for support by the CompInt (International Graduate School of complex interface) of the TU Munchen through a Ph.D. fellowship. R.J. is thankful for further support by the IGSSE (International Graduate School for Science and Engineering). R.J. and C.W. acknowledge support by the Center for Regenerative Therapies Dresden (CRTD). R.L. is thankful for a postdoctoral fellowship of the King Abdullah University of Science and Technology (KAUST, Award. No. KUK-F1-029-32). The authors thank Kati Mittasch and Juliane Drichel for technical support in protein adsorption and cell culture experiments.
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Full metadata record

DC FieldValue Language
dc.contributor.authorZhang, Ningen
dc.contributor.authorPompe, Tiloen
dc.contributor.authorAmin, Ihsanen
dc.contributor.authorLuxenhofer, Roberten
dc.contributor.authorWerner, Carstenen
dc.contributor.authorJordan, Raineren
dc.date.accessioned2016-02-28T06:31:03Zen
dc.date.available2016-02-28T06:31:03Zen
dc.date.issued2012-05-18en
dc.identifier.citationZhang N, Pompe T, Amin I, Luxenhofer R, Werner C, et al. (2012) Tailored Poly(2-oxazoline) Polymer Brushes to Control Protein Adsorption and Cell Adhesion. Macromolecular Bioscience 12: 926–936. Available: http://dx.doi.org/10.1002/mabi.201200026.en
dc.identifier.issn1616-5187en
dc.identifier.pmid22610725en
dc.identifier.doi10.1002/mabi.201200026en
dc.identifier.urihttp://hdl.handle.net/10754/599859en
dc.description.abstractPOx bottle-brush brushes (BBBs) are synthesized by SIPGP of 2-isopropenyl-2-oxazoline and consecutive LCROP of 2-oxazolines on 3-aminopropyltrimethoxysilane-modified silicon substrates. The side chain hydrophilicity and polarity are varied. The impact of the chemical composition and architecture of the BBB upon protein (fibronectin) adsorption and endothelial cell adhesion are investigated and prove extremely low protein adsorption and cell adhesion on BBBs with hydrophilic side chains such as poly(2-methyl-2-oxazoline) and poly(2-ethyl-2-oxazoline). The influence of the POx side chain terminal function upon adsorption and adhesion is minor but the side chain length has a significant effect on bioadsorption. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.en
dc.description.sponsorshipN.Z. is thankful for support by the CompInt (International Graduate School of complex interface) of the TU Munchen through a Ph.D. fellowship. R.J. is thankful for further support by the IGSSE (International Graduate School for Science and Engineering). R.J. and C.W. acknowledge support by the Center for Regenerative Therapies Dresden (CRTD). R.L. is thankful for a postdoctoral fellowship of the King Abdullah University of Science and Technology (KAUST, Award. No. KUK-F1-029-32). The authors thank Kati Mittasch and Juliane Drichel for technical support in protein adsorption and cell culture experiments.en
dc.publisherWiley-Blackwellen
dc.subjectCell adhesionen
dc.subjectPolymer brushesen
dc.subjectPolyoxazolinesen
dc.subjectProtein adsorptionen
dc.subjectSurface-initiated polymerizationen
dc.titleTailored Poly(2-oxazoline) Polymer Brushes to Control Protein Adsorption and Cell Adhesionen
dc.typeArticleen
dc.identifier.journalMacromolecular Bioscienceen
dc.contributor.institutionTechnische Universitat Munchen, Munich, Germanyen
dc.contributor.institutionLeibniz-Institut fur Polymerforschung Dresden e.V., Dresden, Germanyen
dc.contributor.institutionUniversitat Leipzig, Leipzig, Germanyen
dc.contributor.institutionTechnische Universitat Dresden, Dresden, Germanyen
dc.contributor.institutionCenter for Regenerative Therapies Dresden, Dresden, Germanyen
kaust.grant.numberKUK-F1-029-32en

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