Synaptic Bistability Due to Nucleation and Evaporation of Receptor Clusters

Handle URI:
http://hdl.handle.net/10754/599827
Title:
Synaptic Bistability Due to Nucleation and Evaporation of Receptor Clusters
Authors:
Burlakov, V. M.; Emptage, N.; Goriely, A.; Bressloff, P. C.
Abstract:
We introduce a bistability mechanism for long-term synaptic plasticity based on switching between two metastable states that contain significantly different numbers of synaptic receptors. One state is characterized by a two-dimensional gas of mobile interacting receptors and is stabilized against clustering by a high nucleation barrier. The other state contains a receptor gas in equilibrium with a large cluster of immobile receptors, which is stabilized by the turnover rate of receptors into and out of the synapse. Transitions between the two states can be initiated by either an increase (potentiation) or a decrease (depotentiation) of the net receptor flux into the synapse. This changes the saturation level of the receptor gas and triggers nucleation or evaporation of receptor clusters. © 2012 American Physical Society.
Citation:
Burlakov VM, Emptage N, Goriely A, Bressloff PC (2012) Synaptic Bistability Due to Nucleation and Evaporation of Receptor Clusters. Physical Review Letters 108. Available: http://dx.doi.org/10.1103/physrevlett.108.028101.
Publisher:
American Physical Society (APS)
Journal:
Physical Review Letters
KAUST Grant Number:
KUK-C1-013-04
Issue Date:
10-Jan-2012
DOI:
10.1103/physrevlett.108.028101
PubMed ID:
22324711
Type:
Article
ISSN:
0031-9007; 1079-7114
Sponsors:
This work was funded by the John Fell Oxford University Press (OUP) Research Fund. In part, it was also supported by King Abdullah University of Science and Technology Award No. KUK-C1-013-04. A. G. and P. C. B. were supported by Wolfson/Royal Society Merit Awards. N. E. thanks the Medical Research Council (UK) for support.
Appears in Collections:
Publications Acknowledging KAUST Support

Full metadata record

DC FieldValue Language
dc.contributor.authorBurlakov, V. M.en
dc.contributor.authorEmptage, N.en
dc.contributor.authorGoriely, A.en
dc.contributor.authorBressloff, P. C.en
dc.date.accessioned2016-02-28T06:10:45Zen
dc.date.available2016-02-28T06:10:45Zen
dc.date.issued2012-01-10en
dc.identifier.citationBurlakov VM, Emptage N, Goriely A, Bressloff PC (2012) Synaptic Bistability Due to Nucleation and Evaporation of Receptor Clusters. Physical Review Letters 108. Available: http://dx.doi.org/10.1103/physrevlett.108.028101.en
dc.identifier.issn0031-9007en
dc.identifier.issn1079-7114en
dc.identifier.pmid22324711en
dc.identifier.doi10.1103/physrevlett.108.028101en
dc.identifier.urihttp://hdl.handle.net/10754/599827en
dc.description.abstractWe introduce a bistability mechanism for long-term synaptic plasticity based on switching between two metastable states that contain significantly different numbers of synaptic receptors. One state is characterized by a two-dimensional gas of mobile interacting receptors and is stabilized against clustering by a high nucleation barrier. The other state contains a receptor gas in equilibrium with a large cluster of immobile receptors, which is stabilized by the turnover rate of receptors into and out of the synapse. Transitions between the two states can be initiated by either an increase (potentiation) or a decrease (depotentiation) of the net receptor flux into the synapse. This changes the saturation level of the receptor gas and triggers nucleation or evaporation of receptor clusters. © 2012 American Physical Society.en
dc.description.sponsorshipThis work was funded by the John Fell Oxford University Press (OUP) Research Fund. In part, it was also supported by King Abdullah University of Science and Technology Award No. KUK-C1-013-04. A. G. and P. C. B. were supported by Wolfson/Royal Society Merit Awards. N. E. thanks the Medical Research Council (UK) for support.en
dc.publisherAmerican Physical Society (APS)en
dc.titleSynaptic Bistability Due to Nucleation and Evaporation of Receptor Clustersen
dc.typeArticleen
dc.identifier.journalPhysical Review Lettersen
dc.contributor.institutionUniversity of Oxford, Oxford, United Kingdomen
dc.contributor.institutionUniversity of Utah, Salt Lake City, United Statesen
kaust.grant.numberKUK-C1-013-04en

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