Structure-property relationship in cytotoxicity and cell uptake of poly(2-oxazoline) amphiphiles

Handle URI:
http://hdl.handle.net/10754/599777
Title:
Structure-property relationship in cytotoxicity and cell uptake of poly(2-oxazoline) amphiphiles
Authors:
Luxenhofer, Robert; Sahay, Gaurav; Schulz, Anita; Alakhova, Daria; Bronich, Tatiana K.; Jordan, Rainer; Kabanov, Alexander V.
Abstract:
The family of poly(2-oxazoline)s (POx) is being increasingly investigated in the context of biomedical applications. We tested the relative cytotoxicity of POx and were able to confirm that these polymers are typically not cytotoxic even at high concentrations. Furthermore, we report structure-uptake relationships of a series of amphiphilic POx block copolymers that have different architectures, molar mass and chain termini. The rate of endocytosis can be fine-tuned over a broad range by changing the polymer structure. The cellular uptake increases with the hydrophobic character of the polymers and is observed even at nanomolar concentrations. Considering the structural versatility of this class of polymers, the relative ease of preparation and their stability underlines the potential of POx as a promising platform candidate for the preparation of next-generation polymer therapeutics.
Citation:
Luxenhofer R, Sahay G, Schulz A, Alakhova D, Bronich TK, et al. (2011) Structure-property relationship in cytotoxicity and cell uptake of poly(2-oxazoline) amphiphiles. Journal of Controlled Release 153: 73–82. Available: http://dx.doi.org/10.1016/j.jconrel.2011.04.010.
Publisher:
Elsevier BV
Journal:
Journal of Controlled Release
KAUST Grant Number:
KUK-F1-029-32
Issue Date:
Jul-2011
DOI:
10.1016/j.jconrel.2011.04.010
PubMed ID:
21513750
PubMed Central ID:
PMC3134160
Type:
Article
ISSN:
0168-3659
Sponsors:
RI gratefully acknowledges a postdoctoral fellowship of the Deutscher Akademischer Austauschdienst (DAAD) and the King Abdullah University of Science and Technology (KAUST, Award No. KUK-F1-029-32) for partial salary support. This study was supported by National Institutes of Health grants 1P20 RR021937, UO1 CA151806 and 2RO1 CA89225 awarded to AVK and the DFG Forschergruppe FOR411 "Radionuklidtherapie" awarded to RJ (project P12). We would also like to thank the flow cytometry and confocal microscopy core facilities at UNMC.
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Full metadata record

DC FieldValue Language
dc.contributor.authorLuxenhofer, Roberten
dc.contributor.authorSahay, Gauraven
dc.contributor.authorSchulz, Anitaen
dc.contributor.authorAlakhova, Dariaen
dc.contributor.authorBronich, Tatiana K.en
dc.contributor.authorJordan, Raineren
dc.contributor.authorKabanov, Alexander V.en
dc.date.accessioned2016-02-28T06:09:35Zen
dc.date.available2016-02-28T06:09:35Zen
dc.date.issued2011-07en
dc.identifier.citationLuxenhofer R, Sahay G, Schulz A, Alakhova D, Bronich TK, et al. (2011) Structure-property relationship in cytotoxicity and cell uptake of poly(2-oxazoline) amphiphiles. Journal of Controlled Release 153: 73–82. Available: http://dx.doi.org/10.1016/j.jconrel.2011.04.010.en
dc.identifier.issn0168-3659en
dc.identifier.pmid21513750en
dc.identifier.doi10.1016/j.jconrel.2011.04.010en
dc.identifier.urihttp://hdl.handle.net/10754/599777en
dc.description.abstractThe family of poly(2-oxazoline)s (POx) is being increasingly investigated in the context of biomedical applications. We tested the relative cytotoxicity of POx and were able to confirm that these polymers are typically not cytotoxic even at high concentrations. Furthermore, we report structure-uptake relationships of a series of amphiphilic POx block copolymers that have different architectures, molar mass and chain termini. The rate of endocytosis can be fine-tuned over a broad range by changing the polymer structure. The cellular uptake increases with the hydrophobic character of the polymers and is observed even at nanomolar concentrations. Considering the structural versatility of this class of polymers, the relative ease of preparation and their stability underlines the potential of POx as a promising platform candidate for the preparation of next-generation polymer therapeutics.en
dc.description.sponsorshipRI gratefully acknowledges a postdoctoral fellowship of the Deutscher Akademischer Austauschdienst (DAAD) and the King Abdullah University of Science and Technology (KAUST, Award No. KUK-F1-029-32) for partial salary support. This study was supported by National Institutes of Health grants 1P20 RR021937, UO1 CA151806 and 2RO1 CA89225 awarded to AVK and the DFG Forschergruppe FOR411 "Radionuklidtherapie" awarded to RJ (project P12). We would also like to thank the flow cytometry and confocal microscopy core facilities at UNMC.en
dc.publisherElsevier BVen
dc.subjectamphiphilic block copolymeren
dc.subjectbiocompatibilityen
dc.subjectdrug deliveryen
dc.subjectendocytosisen
dc.subjectflow cytometryen
dc.titleStructure-property relationship in cytotoxicity and cell uptake of poly(2-oxazoline) amphiphilesen
dc.typeArticleen
dc.identifier.journalJournal of Controlled Releaseen
dc.identifier.pmcidPMC3134160en
dc.contributor.institutionWACKER-Lehrstuhl für Makromolekulare Stoffe, Department Chemie, Technische Universität München, Lichtenbergstr. 4, 85747 Garching, Germany. robert.luxenhofer@chemie.tu-dresden.deen
kaust.grant.numberKUK-F1-029-32en

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