Handle URI:
http://hdl.handle.net/10754/599758
Title:
Structural repertoire of immunoglobulin λ light chains
Authors:
Chailyan, Anna; Marcatili, Paolo; Cirillo, Davide; Tramontano, Anna
Abstract:
The immunoglobulin λ isotype is present in nearly all vertebrates and plays an important role in the human immune system. Despite its importance, few systematic studies have been performed to analyze the structural conformation of its variable regions, contrary to what is the case for κ and heavy chains. We show here that an analysis of the structures of λ chains allows the definition of a discrete set of recurring conformations (canonical structures) of their hypervariable loops and, most importantly, the identification of sequence constraints that can be used to predict their structure. We also show that the structural repertoire of λ chains is different and more varied than that of the κ chains, consistently with the current view of the involvement of the two major light-chain families in complementary strategies of the immune system to ensure a fine tuning between diversity and stability in antigen recognition. © 2011 Wiley-Liss, Inc.
Citation:
Chailyan A, Marcatili P, Cirillo D, Tramontano A (2011) Structural repertoire of immunoglobulin λ light chains. Proteins: Structure, Function, and Bioinformatics 79: 1513–1524. Available: http://dx.doi.org/10.1002/prot.22979.
Publisher:
Wiley-Blackwell
Journal:
Proteins: Structure, Function, and Bioinformatics
KAUST Grant Number:
KUK-I1-012-43
Issue Date:
1-Mar-2011
DOI:
10.1002/prot.22979
PubMed ID:
21365679
Type:
Article
ISSN:
0887-3585
Sponsors:
Grant sponsor: King Abdullah University of Science and Technology (KAUST); Grant number: KUK-I1-012-43; Grant sponsor: Ministero della Salute; Grant number: RF-IDI-2006-354931; Grant sponsor: FIRB Italbionet and Proteomica
Appears in Collections:
Publications Acknowledging KAUST Support

Full metadata record

DC FieldValue Language
dc.contributor.authorChailyan, Annaen
dc.contributor.authorMarcatili, Paoloen
dc.contributor.authorCirillo, Davideen
dc.contributor.authorTramontano, Annaen
dc.date.accessioned2016-02-28T06:09:08Zen
dc.date.available2016-02-28T06:09:08Zen
dc.date.issued2011-03-01en
dc.identifier.citationChailyan A, Marcatili P, Cirillo D, Tramontano A (2011) Structural repertoire of immunoglobulin λ light chains. Proteins: Structure, Function, and Bioinformatics 79: 1513–1524. Available: http://dx.doi.org/10.1002/prot.22979.en
dc.identifier.issn0887-3585en
dc.identifier.pmid21365679en
dc.identifier.doi10.1002/prot.22979en
dc.identifier.urihttp://hdl.handle.net/10754/599758en
dc.description.abstractThe immunoglobulin λ isotype is present in nearly all vertebrates and plays an important role in the human immune system. Despite its importance, few systematic studies have been performed to analyze the structural conformation of its variable regions, contrary to what is the case for κ and heavy chains. We show here that an analysis of the structures of λ chains allows the definition of a discrete set of recurring conformations (canonical structures) of their hypervariable loops and, most importantly, the identification of sequence constraints that can be used to predict their structure. We also show that the structural repertoire of λ chains is different and more varied than that of the κ chains, consistently with the current view of the involvement of the two major light-chain families in complementary strategies of the immune system to ensure a fine tuning between diversity and stability in antigen recognition. © 2011 Wiley-Liss, Inc.en
dc.description.sponsorshipGrant sponsor: King Abdullah University of Science and Technology (KAUST); Grant number: KUK-I1-012-43; Grant sponsor: Ministero della Salute; Grant number: RF-IDI-2006-354931; Grant sponsor: FIRB Italbionet and Proteomicaen
dc.publisherWiley-Blackwellen
dc.subjectCanonical structuresen
dc.subjectImmunoglobulinsen
dc.subjectLambda chainsen
dc.titleStructural repertoire of immunoglobulin λ light chainsen
dc.typeArticleen
dc.identifier.journalProteins: Structure, Function, and Bioinformaticsen
dc.contributor.institutionUniversita degli Studi di Roma La Sapienza, Rome, Italyen
kaust.grant.numberKUK-I1-012-43en
All Items in KAUST are protected by copyright, with all rights reserved, unless otherwise indicated.