Refillable and magnetically actuated drug delivery system using pear-shaped viscoelastic membrane

Handle URI:
http://hdl.handle.net/10754/599481
Title:
Refillable and magnetically actuated drug delivery system using pear-shaped viscoelastic membrane
Authors:
So, Hongyun; Seo, Young Ho; Pisano, Albert P.
Abstract:
We report a refillable and valveless drug delivery device actuated by an external magnetic field for on-demand drug release to treat localized diseases. The device features a pear-shaped viscoelastic magnetic membrane inducing asymmetrical deflection and consecutive touchdown motion to the bottom of the dome-shaped drug reservoir in response to a magnetic field, thus achieving controlled discharge of the drug. Maximum drug release with 18 ± 1.5 μg per actuation was achieved under a 500 mT magnetic flux density, and various controlled drug doses were investigated with the combination of the number of accumulated actuations and the strength of the magnetic field.
Citation:
So H, Seo YH, Pisano AP (2014) Refillable and magnetically actuated drug delivery system using pear-shaped viscoelastic membrane. Biomicrofluidics 8: 044119. Available: http://dx.doi.org/10.1063/1.4893912.
Publisher:
AIP Publishing
Journal:
Biomicrofluidics
Issue Date:
Jul-2014
DOI:
10.1063/1.4893912
PubMed ID:
25379104
PubMed Central ID:
PMC4189303
Type:
Article
ISSN:
1932-1058
Sponsors:
This work was supported by the KAUST Global Collaborative Research grant under the Academic Excellence Alliance program. The authors also thank the UC Berkeley Marvell Nanolab and Biomolecular Nanotechnology Center where all devices were fabricated.
Appears in Collections:
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Full metadata record

DC FieldValue Language
dc.contributor.authorSo, Hongyunen
dc.contributor.authorSeo, Young Hoen
dc.contributor.authorPisano, Albert P.en
dc.date.accessioned2016-02-28T05:51:56Zen
dc.date.available2016-02-28T05:51:56Zen
dc.date.issued2014-07en
dc.identifier.citationSo H, Seo YH, Pisano AP (2014) Refillable and magnetically actuated drug delivery system using pear-shaped viscoelastic membrane. Biomicrofluidics 8: 044119. Available: http://dx.doi.org/10.1063/1.4893912.en
dc.identifier.issn1932-1058en
dc.identifier.pmid25379104en
dc.identifier.doi10.1063/1.4893912en
dc.identifier.urihttp://hdl.handle.net/10754/599481en
dc.description.abstractWe report a refillable and valveless drug delivery device actuated by an external magnetic field for on-demand drug release to treat localized diseases. The device features a pear-shaped viscoelastic magnetic membrane inducing asymmetrical deflection and consecutive touchdown motion to the bottom of the dome-shaped drug reservoir in response to a magnetic field, thus achieving controlled discharge of the drug. Maximum drug release with 18 ± 1.5 μg per actuation was achieved under a 500 mT magnetic flux density, and various controlled drug doses were investigated with the combination of the number of accumulated actuations and the strength of the magnetic field.en
dc.description.sponsorshipThis work was supported by the KAUST Global Collaborative Research grant under the Academic Excellence Alliance program. The authors also thank the UC Berkeley Marvell Nanolab and Biomolecular Nanotechnology Center where all devices were fabricated.en
dc.publisherAIP Publishingen
dc.titleRefillable and magnetically actuated drug delivery system using pear-shaped viscoelastic membraneen
dc.typeArticleen
dc.identifier.journalBiomicrofluidicsen
dc.identifier.pmcidPMC4189303en
dc.contributor.institutionDepartment of Mechanical Engineering, University of California , Berkeley, California 94720, USA.en
dc.contributor.institutionDepartment of Mechanical and Mechatronics Engineering, Kangwon National University , Chuncheon, Gangwon-do 200-701, South Korea.en
kaust.grant.programAcademic Excellence Alliance (AEA)en

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