Preparation and Characterization of Amphiphilic Triblock Terpolymer-Based Nanofibers as Antifouling Biomaterials

Handle URI:
http://hdl.handle.net/10754/599389
Title:
Preparation and Characterization of Amphiphilic Triblock Terpolymer-Based Nanofibers as Antifouling Biomaterials
Authors:
Cho, Youngjin; Cho, Daehwan; Park, Jay Hoon; Frey, Margaret W.; Ober, Christopher K.; Joo, Yong Lak
Abstract:
Antifouling surfaces are critical for the good performance of functional materials in various applications including water filtration, medical implants, and biosensors. In this study, we synthesized amphiphilic triblock terpolymers (tri-BCPs, coded as KB) and fabricated amphiphilic nanofibers by electrospinning of solutions prepared by mixing the KB with poly(lactic acid) (PLA) polymer. The resulting fibers with amphiphilic polymer groups exhibited superior antifouling performance to the fibers without such groups. The adsorption of bovine serum albumin (BSA) on the amphiphilic fibers was about 10-fold less than that on the control surfaces from PLA and PET fibers. With the increase of the KB content in the amphiphilic fibers, the resistance to adsorption of BSA was increased. BSA was released more easily from the surface of the amphiphilic fibers than from the surface of hydrophobic PLA or PET fibers. We have also investigated the structural conformation of KB in fibers before and after annealing by contact angle measurements, transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy (EDX), and coarse-grained molecular dynamics (CGMD) simulation to probe the effect of amphiphilic chain conformation on antifouling. The results reveal that the amphiphilic KB was evenly distributed within as-spun hybrid fibers, while migrated toward the core from the fiber surface during thermal treatment, leading to the reduction in antifouling. This suggests that the antifouling effect of the amphiphilic fibers is greatly influenced by the arrangement of amphiphilic groups in the fibers. © 2012 American Chemical Society.
Citation:
Cho Y, Cho D, Park JH, Frey MW, Ober CK, et al. (2012) Preparation and Characterization of Amphiphilic Triblock Terpolymer-Based Nanofibers as Antifouling Biomaterials. Biomacromolecules 13: 1606–1614. Available: http://dx.doi.org/10.1021/bm300327w.
Publisher:
American Chemical Society (ACS)
Journal:
Biomacromolecules
Issue Date:
14-May-2012
DOI:
10.1021/bm300327w
PubMed ID:
22471871
Type:
Article
ISSN:
1525-7797; 1526-4602
Sponsors:
The authors are grateful for the financial support from NSF CBET-0852900 and the National Textile Center. This work was partially supported by the Office of Naval Research (ONR) through Award #N00014-02-1-0170, as well as through the KAUST CU Center for Energy and Sustainability.
Appears in Collections:
Publications Acknowledging KAUST Support

Full metadata record

DC FieldValue Language
dc.contributor.authorCho, Youngjinen
dc.contributor.authorCho, Daehwanen
dc.contributor.authorPark, Jay Hoonen
dc.contributor.authorFrey, Margaret W.en
dc.contributor.authorOber, Christopher K.en
dc.contributor.authorJoo, Yong Laken
dc.date.accessioned2016-02-28T05:50:11Zen
dc.date.available2016-02-28T05:50:11Zen
dc.date.issued2012-05-14en
dc.identifier.citationCho Y, Cho D, Park JH, Frey MW, Ober CK, et al. (2012) Preparation and Characterization of Amphiphilic Triblock Terpolymer-Based Nanofibers as Antifouling Biomaterials. Biomacromolecules 13: 1606–1614. Available: http://dx.doi.org/10.1021/bm300327w.en
dc.identifier.issn1525-7797en
dc.identifier.issn1526-4602en
dc.identifier.pmid22471871en
dc.identifier.doi10.1021/bm300327wen
dc.identifier.urihttp://hdl.handle.net/10754/599389en
dc.description.abstractAntifouling surfaces are critical for the good performance of functional materials in various applications including water filtration, medical implants, and biosensors. In this study, we synthesized amphiphilic triblock terpolymers (tri-BCPs, coded as KB) and fabricated amphiphilic nanofibers by electrospinning of solutions prepared by mixing the KB with poly(lactic acid) (PLA) polymer. The resulting fibers with amphiphilic polymer groups exhibited superior antifouling performance to the fibers without such groups. The adsorption of bovine serum albumin (BSA) on the amphiphilic fibers was about 10-fold less than that on the control surfaces from PLA and PET fibers. With the increase of the KB content in the amphiphilic fibers, the resistance to adsorption of BSA was increased. BSA was released more easily from the surface of the amphiphilic fibers than from the surface of hydrophobic PLA or PET fibers. We have also investigated the structural conformation of KB in fibers before and after annealing by contact angle measurements, transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy (EDX), and coarse-grained molecular dynamics (CGMD) simulation to probe the effect of amphiphilic chain conformation on antifouling. The results reveal that the amphiphilic KB was evenly distributed within as-spun hybrid fibers, while migrated toward the core from the fiber surface during thermal treatment, leading to the reduction in antifouling. This suggests that the antifouling effect of the amphiphilic fibers is greatly influenced by the arrangement of amphiphilic groups in the fibers. © 2012 American Chemical Society.en
dc.description.sponsorshipThe authors are grateful for the financial support from NSF CBET-0852900 and the National Textile Center. This work was partially supported by the Office of Naval Research (ONR) through Award #N00014-02-1-0170, as well as through the KAUST CU Center for Energy and Sustainability.en
dc.publisherAmerican Chemical Society (ACS)en
dc.titlePreparation and Characterization of Amphiphilic Triblock Terpolymer-Based Nanofibers as Antifouling Biomaterialsen
dc.typeArticleen
dc.identifier.journalBiomacromoleculesen
dc.contributor.institutionCornell University, Ithaca, United Statesen

Related articles on PubMed

All Items in KAUST are protected by copyright, with all rights reserved, unless otherwise indicated.