Polypeptoids: A perfect match for molecular definition and macromolecular engineering?

Handle URI:
http://hdl.handle.net/10754/599219
Title:
Polypeptoids: A perfect match for molecular definition and macromolecular engineering?
Authors:
Luxenhofer, Robert; Fetsch, Corinna; Grossmann, Arlett
Abstract:
Precision synthesis of polymers has been a hot topic in recent years. While this is notoriously difficult to address for polymers with a CC backbone, Merrifield has discovered a way many decades ago for polypeptides. Using a similar approach, N-substituted polypeptides, so-called polypeptoids have been synthesized and studied for about 20 years. In contrast, the living ring-opening polymerization (ROP) of N-substituted N-carboxyanhydrides was among the first living polymerizations to be discovered. More recently, a surge in new synthetic approaches led to the efficient synthesis of cyclic or linear multiblock copolypeptoids. Thus, polypeptoids can be synthesized either by solid phase synthesis to yield complex and exactly defined oligo- and small polymers or by ROP of appropriately N-substituted N-carboxyanhydrides (NNCA) to give linear, cyclic, or star-like polymers. Together with an excellent biocompatibility, this polymer family may have a bright future ahead as biomaterials. © 2013 Wiley Periodicals, Inc.
Citation:
Luxenhofer R, Fetsch C, Grossmann A (2013) Polypeptoids: A perfect match for molecular definition and macromolecular engineering? Journal of Polymer Science Part A: Polymer Chemistry 51: 2731–2752. Available: http://dx.doi.org/10.1002/pola.26687.
Publisher:
Wiley-Blackwell
Journal:
Journal of Polymer Science Part A: Polymer Chemistry
Issue Date:
19-Apr-2013
DOI:
10.1002/pola.26687
Type:
Article
ISSN:
0887-624X
Sponsors:
R. Luxenhofer gratefully acknowledges financial support by the King Abdullah University of Science and Technology (KAUST) and the Fonds der Chemischen Industrie.
Appears in Collections:
Publications Acknowledging KAUST Support

Full metadata record

DC FieldValue Language
dc.contributor.authorLuxenhofer, Roberten
dc.contributor.authorFetsch, Corinnaen
dc.contributor.authorGrossmann, Arletten
dc.date.accessioned2016-02-25T13:55:09Zen
dc.date.available2016-02-25T13:55:09Zen
dc.date.issued2013-04-19en
dc.identifier.citationLuxenhofer R, Fetsch C, Grossmann A (2013) Polypeptoids: A perfect match for molecular definition and macromolecular engineering? Journal of Polymer Science Part A: Polymer Chemistry 51: 2731–2752. Available: http://dx.doi.org/10.1002/pola.26687.en
dc.identifier.issn0887-624Xen
dc.identifier.doi10.1002/pola.26687en
dc.identifier.urihttp://hdl.handle.net/10754/599219en
dc.description.abstractPrecision synthesis of polymers has been a hot topic in recent years. While this is notoriously difficult to address for polymers with a CC backbone, Merrifield has discovered a way many decades ago for polypeptides. Using a similar approach, N-substituted polypeptides, so-called polypeptoids have been synthesized and studied for about 20 years. In contrast, the living ring-opening polymerization (ROP) of N-substituted N-carboxyanhydrides was among the first living polymerizations to be discovered. More recently, a surge in new synthetic approaches led to the efficient synthesis of cyclic or linear multiblock copolypeptoids. Thus, polypeptoids can be synthesized either by solid phase synthesis to yield complex and exactly defined oligo- and small polymers or by ROP of appropriately N-substituted N-carboxyanhydrides (NNCA) to give linear, cyclic, or star-like polymers. Together with an excellent biocompatibility, this polymer family may have a bright future ahead as biomaterials. © 2013 Wiley Periodicals, Inc.en
dc.description.sponsorshipR. Luxenhofer gratefully acknowledges financial support by the King Abdullah University of Science and Technology (KAUST) and the Fonds der Chemischen Industrie.en
dc.publisherWiley-Blackwellen
dc.subjectbiomaterialsen
dc.subjectbiomimeticen
dc.subjectcyclic polymersen
dc.subjectliving polymerizationen
dc.subjectmultiblock copolymersen
dc.subjectnonfoulingen
dc.subjectprecision polymersen
dc.subjectsolid phase synthesisen
dc.subjectsurface initiated polymerizationen
dc.titlePolypeptoids: A perfect match for molecular definition and macromolecular engineering?en
dc.typeArticleen
dc.identifier.journalJournal of Polymer Science Part A: Polymer Chemistryen
dc.contributor.institutionFunctional Polymer Materials; Chair of Chemical Technology of Materials Synthesis; Department of Chemistry and Pharmacy, Julius-Maximilian, University of Würzburg; 97070; Würzburg; Germanyen
dc.contributor.institutionProfessur für Makromolekulare Chemie; Department Chemie; Technische Universität Dresden; 01062; Dresden; Germanyen
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