Polypeptoids from N -Substituted Glycine N -Carboxyanhydrides: Hydrophilic, Hydrophobic, and Amphiphilic Polymers with Poisson Distribution

Handle URI:
http://hdl.handle.net/10754/599218
Title:
Polypeptoids from N -Substituted Glycine N -Carboxyanhydrides: Hydrophilic, Hydrophobic, and Amphiphilic Polymers with Poisson Distribution
Authors:
Fetsch, Corinna; Grossmann, Arlett; Holz, Lisa; Nawroth, Jonas F.; Luxenhofer, Robert
Abstract:
Preparation of defined and functional polymers has been one of the hottest topics in polymer science and drug delivery in the recent decade. Also, research on (bio)degradable polymers gains more and more interest, in particular at the interface of these two disciplines. However, in the majority of cases, combination of definition, functionality and degradability, is problematic. Here we present the preparation and characterization (MALDI-ToF MS, NMR, GPC) of nonionic hydrophilic, hydrophobic, and amphiphilic N-substituted polyglycines (polypeptoids), which are expected to be main-chain degradable and are able to disperse a hydrophobic model compound in aqueous media. Polymerization kinetics suggest that the polymerization is well controlled with strictly linear pseudo first-order kinetic plots to high monomer consumption. Moreover, molar mass distributions of products are Poisson-type and molar mass can be controlled by the monomer to initiator ratio. The presented polymer platform is nonionic, backbone degradable, and synthetically highly flexible and may therefore be valuable for a broad range of applications, in particular as a biomaterial. © 2011 American Chemical Society.
Citation:
Fetsch C, Grossmann A, Holz L, Nawroth JF, Luxenhofer R (2011) Polypeptoids from N -Substituted Glycine N -Carboxyanhydrides: Hydrophilic, Hydrophobic, and Amphiphilic Polymers with Poisson Distribution . Macromolecules 44: 6746–6758. Available: http://dx.doi.org/10.1021/ma201015y.
Publisher:
American Chemical Society (ACS)
Journal:
Macromolecules
KAUST Grant Number:
KUK-F1-029-32
Issue Date:
13-Sep-2011
DOI:
10.1021/ma201015y
Type:
Article
ISSN:
0024-9297; 1520-5835
Sponsors:
This publication is based on work supported by Award No. KUK-F1-029-32, made by King Abdullah University of Science and Technology (KAUST). We would like to acknowledge helpful discussions on infra red spectroscopy and ongoing support by Prof. Rainer Jordan.
Appears in Collections:
Publications Acknowledging KAUST Support

Full metadata record

DC FieldValue Language
dc.contributor.authorFetsch, Corinnaen
dc.contributor.authorGrossmann, Arletten
dc.contributor.authorHolz, Lisaen
dc.contributor.authorNawroth, Jonas F.en
dc.contributor.authorLuxenhofer, Roberten
dc.date.accessioned2016-02-25T13:55:08Zen
dc.date.available2016-02-25T13:55:08Zen
dc.date.issued2011-09-13en
dc.identifier.citationFetsch C, Grossmann A, Holz L, Nawroth JF, Luxenhofer R (2011) Polypeptoids from N -Substituted Glycine N -Carboxyanhydrides: Hydrophilic, Hydrophobic, and Amphiphilic Polymers with Poisson Distribution . Macromolecules 44: 6746–6758. Available: http://dx.doi.org/10.1021/ma201015y.en
dc.identifier.issn0024-9297en
dc.identifier.issn1520-5835en
dc.identifier.doi10.1021/ma201015yen
dc.identifier.urihttp://hdl.handle.net/10754/599218en
dc.description.abstractPreparation of defined and functional polymers has been one of the hottest topics in polymer science and drug delivery in the recent decade. Also, research on (bio)degradable polymers gains more and more interest, in particular at the interface of these two disciplines. However, in the majority of cases, combination of definition, functionality and degradability, is problematic. Here we present the preparation and characterization (MALDI-ToF MS, NMR, GPC) of nonionic hydrophilic, hydrophobic, and amphiphilic N-substituted polyglycines (polypeptoids), which are expected to be main-chain degradable and are able to disperse a hydrophobic model compound in aqueous media. Polymerization kinetics suggest that the polymerization is well controlled with strictly linear pseudo first-order kinetic plots to high monomer consumption. Moreover, molar mass distributions of products are Poisson-type and molar mass can be controlled by the monomer to initiator ratio. The presented polymer platform is nonionic, backbone degradable, and synthetically highly flexible and may therefore be valuable for a broad range of applications, in particular as a biomaterial. © 2011 American Chemical Society.en
dc.description.sponsorshipThis publication is based on work supported by Award No. KUK-F1-029-32, made by King Abdullah University of Science and Technology (KAUST). We would like to acknowledge helpful discussions on infra red spectroscopy and ongoing support by Prof. Rainer Jordan.en
dc.publisherAmerican Chemical Society (ACS)en
dc.titlePolypeptoids from N -Substituted Glycine N -Carboxyanhydrides: Hydrophilic, Hydrophobic, and Amphiphilic Polymers with Poisson Distributionen
dc.typeArticleen
dc.identifier.journalMacromoleculesen
dc.contributor.institutionTechnische Universitat Dresden, Dresden, Germanyen
kaust.grant.numberKUK-F1-029-32en
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