Nonlinear electro-mechanobiological behavior of cell membrane during electroporation

Handle URI:
http://hdl.handle.net/10754/598990
Title:
Nonlinear electro-mechanobiological behavior of cell membrane during electroporation
Authors:
Deng, Peigang; Lee, Yi-Kuen; Lin, Ran; Zhang, Tong-Yi
Abstract:
A nonlinear electroporation (EP) model is proposed to study the electro-mechanobiological behavior of cell membrane during EP, by taking the nonlinear large deformation of the membrane into account. The proposed model predicts the critical transmembrane potential and the activation energy for EP, the equilibrium pore size, and the resealing process of the pore. Single-cell EP experiments using a micro EP chip were conducted on chicken red blood cells at different temperatures to determine the activation energy and the critical transmembrane potential for EP. The experimental results are in good agreement with the theoretical predictions. © 2012 American Institute of Physics.
Citation:
Deng P, Lee Y-K, Lin R, Zhang T-Y (2012) Nonlinear electro-mechanobiological behavior of cell membrane during electroporation. Applied Physics Letters 101: 053702. Available: http://dx.doi.org/10.1063/1.4739940.
Publisher:
AIP Publishing
Journal:
Applied Physics Letters
KAUST Grant Number:
SA-C0040/UK-C0016
Issue Date:
2012
DOI:
10.1063/1.4739940
Type:
Article
ISSN:
0003-6951
Sponsors:
This research was partially supported by a Hong Kong RGC grant (No. 615907) and by an award from the King Abdullah University of Science and Technology (KAUST Award No. SA-C0040/UK-C0016).
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Full metadata record

DC FieldValue Language
dc.contributor.authorDeng, Peigangen
dc.contributor.authorLee, Yi-Kuenen
dc.contributor.authorLin, Ranen
dc.contributor.authorZhang, Tong-Yien
dc.date.accessioned2016-02-25T13:50:43Zen
dc.date.available2016-02-25T13:50:43Zen
dc.date.issued2012en
dc.identifier.citationDeng P, Lee Y-K, Lin R, Zhang T-Y (2012) Nonlinear electro-mechanobiological behavior of cell membrane during electroporation. Applied Physics Letters 101: 053702. Available: http://dx.doi.org/10.1063/1.4739940.en
dc.identifier.issn0003-6951en
dc.identifier.doi10.1063/1.4739940en
dc.identifier.urihttp://hdl.handle.net/10754/598990en
dc.description.abstractA nonlinear electroporation (EP) model is proposed to study the electro-mechanobiological behavior of cell membrane during EP, by taking the nonlinear large deformation of the membrane into account. The proposed model predicts the critical transmembrane potential and the activation energy for EP, the equilibrium pore size, and the resealing process of the pore. Single-cell EP experiments using a micro EP chip were conducted on chicken red blood cells at different temperatures to determine the activation energy and the critical transmembrane potential for EP. The experimental results are in good agreement with the theoretical predictions. © 2012 American Institute of Physics.en
dc.description.sponsorshipThis research was partially supported by a Hong Kong RGC grant (No. 615907) and by an award from the King Abdullah University of Science and Technology (KAUST Award No. SA-C0040/UK-C0016).en
dc.publisherAIP Publishingen
dc.titleNonlinear electro-mechanobiological behavior of cell membrane during electroporationen
dc.typeArticleen
dc.identifier.journalApplied Physics Lettersen
dc.contributor.institutionWuhan Institute of Technology, Wuhan, Chinaen
dc.contributor.institutionHong Kong University of Science and Technology, Hong Kong, Chinaen
kaust.grant.numberSA-C0040/UK-C0016en
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