Handle URI:
http://hdl.handle.net/10754/598838
Title:
Mini-review: Molecular mechanisms of antifouling compounds
Authors:
Qian, Pei-Yuan; Chen, Lianguo; Xu, Ying
Abstract:
Various antifouling (AF) coatings have been developed to protect submerged surfaces by deterring the settlement of the colonizing stages of fouling organisms. A review of the literature shows that effective AF compounds with specific targets are ones often considered non-toxic. Such compounds act variously on ion channels, quorum sensing systems, neurotransmitters, production/release of adhesive, and specific enzymes that regulate energy production or primary metabolism. In contrast, AF compounds with general targets may or may not act through toxic mechanisms. These compounds affect a variety of biological activities including algal photosynthesis, energy production, stress responses, genotoxic damage, immunosuppressed protein expression, oxidation, neurotransmission, surface chemistry, the formation of biofilms, and adhesive production/release. Among all the targets, adhesive production/release is the most common, possibly due to a more extensive research effort in this area. Overall, the specific molecular targets and the molecular mechanisms of most AF compounds have not been identified. Thus, the information available is insufficient to draw firm conclusions about the types of molecular targets to be used as sensitive biomarkers for future design and screening of compounds with AF potential. In this review, the relevant advantages and disadvantages of the molecular tools available for studying the molecular targets of AF compounds are highlighted briefly and the molecular mechanisms of the AF compounds, which are largely a source of speculation in the literature, are discussed. © 2013 Copyright Taylor and Francis Group, LLC.
Citation:
Qian P-Y, Chen L, Xu Y (2013) Mini-review: Molecular mechanisms of antifouling compounds. Biofouling 29: 381–400. Available: http://dx.doi.org/10.1080/08927014.2013.776546.
Publisher:
Informa UK Limited
Journal:
Biofouling
KAUST Grant Number:
SA-C0040; UK-C0016
Issue Date:
Apr-2013
DOI:
10.1080/08927014.2013.776546
PubMed ID:
23574197
Type:
Article
ISSN:
0892-7014; 1029-2454
Sponsors:
The authors would like to thank the three reviewers and the editor for their constructive comments on the MS. This study was supported by a grant from China Ocean Mineral Resources Research and Development (DY125-15-T-02), and an award (SA-C0040/UK-C0016) from the King Abdullah University of Science and Technology to P-Y Qian.
Appears in Collections:
Publications Acknowledging KAUST Support

Full metadata record

DC FieldValue Language
dc.contributor.authorQian, Pei-Yuanen
dc.contributor.authorChen, Lianguoen
dc.contributor.authorXu, Yingen
dc.date.accessioned2016-02-25T13:42:11Zen
dc.date.available2016-02-25T13:42:11Zen
dc.date.issued2013-04en
dc.identifier.citationQian P-Y, Chen L, Xu Y (2013) Mini-review: Molecular mechanisms of antifouling compounds. Biofouling 29: 381–400. Available: http://dx.doi.org/10.1080/08927014.2013.776546.en
dc.identifier.issn0892-7014en
dc.identifier.issn1029-2454en
dc.identifier.pmid23574197en
dc.identifier.doi10.1080/08927014.2013.776546en
dc.identifier.urihttp://hdl.handle.net/10754/598838en
dc.description.abstractVarious antifouling (AF) coatings have been developed to protect submerged surfaces by deterring the settlement of the colonizing stages of fouling organisms. A review of the literature shows that effective AF compounds with specific targets are ones often considered non-toxic. Such compounds act variously on ion channels, quorum sensing systems, neurotransmitters, production/release of adhesive, and specific enzymes that regulate energy production or primary metabolism. In contrast, AF compounds with general targets may or may not act through toxic mechanisms. These compounds affect a variety of biological activities including algal photosynthesis, energy production, stress responses, genotoxic damage, immunosuppressed protein expression, oxidation, neurotransmission, surface chemistry, the formation of biofilms, and adhesive production/release. Among all the targets, adhesive production/release is the most common, possibly due to a more extensive research effort in this area. Overall, the specific molecular targets and the molecular mechanisms of most AF compounds have not been identified. Thus, the information available is insufficient to draw firm conclusions about the types of molecular targets to be used as sensitive biomarkers for future design and screening of compounds with AF potential. In this review, the relevant advantages and disadvantages of the molecular tools available for studying the molecular targets of AF compounds are highlighted briefly and the molecular mechanisms of the AF compounds, which are largely a source of speculation in the literature, are discussed. © 2013 Copyright Taylor and Francis Group, LLC.en
dc.description.sponsorshipThe authors would like to thank the three reviewers and the editor for their constructive comments on the MS. This study was supported by a grant from China Ocean Mineral Resources Research and Development (DY125-15-T-02), and an award (SA-C0040/UK-C0016) from the King Abdullah University of Science and Technology to P-Y Qian.en
dc.publisherInforma UK Limiteden
dc.subjectantifouling compoundsen
dc.subjectmode of actionen
dc.subjectmolecular mechanismsen
dc.subjectmolecular methodologyen
dc.subjectmolecular targetsen
dc.titleMini-review: Molecular mechanisms of antifouling compoundsen
dc.typeArticleen
dc.identifier.journalBiofoulingen
dc.contributor.institutionThe University of Hong Kong, Pokfulam, Hong Kongen
kaust.grant.numberSA-C0040en
kaust.grant.numberUK-C0016en

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