Magnetoliposomes for controlled drug release in the presence of low-frequency magnetic field

Handle URI:
http://hdl.handle.net/10754/598751
Title:
Magnetoliposomes for controlled drug release in the presence of low-frequency magnetic field
Authors:
Nappini, Silvia; Bombelli, Francesca Baldelli; Bonini, Massimo; Nordèn, Bengt; Baglioni, Piero
Abstract:
In this work we have studied the effect of a low-frequency alternating magnetic field (LF-AMF) on the permeability of magnetoliposomes, i.e. liposomes including magnetic nanoparticles within their water pool. Large unilamellar liposomes loaded with magnetic cobalt ferrite nanoparticles (CoFe 2O4) have been prepared and characterized. Structural characterization of the liposomal dispersion has been performed by dynamic light scattering (DLS). The enhancement of liposome permeability upon exposure to LF-AMF has been measured as the self-quenching decrease of a fluorescent hydrophilic molecule (carboxyfluorescein, CF) entrapped in the liposome pool. Liposome leakage has been monitored as a function of field frequency, time of exposure and concentration, charge and size of the embedded nanoparticles. The results show that CF release from magnetoliposomes is strongly promoted by LF-AMF, reasonably as a consequence of nanoparticle motions in the liposome pool at the applied frequency. CF release as a function of time in magnetoliposomes unexposed to magnetic field follows Fickian diffusion, while samples exposed to LF-AMF show zero-order kinetics, consistently with an anomalous transport, due to an alteration of the bilayer permeability. These preliminary results open up new perspectives in the use of these systems as carriers in targeted and controlled release of drugs. © The Royal Society of Chemistry 2010.
Citation:
Nappini S, Bombelli FB, Bonini M, Nordèn B, Baglioni P (2010) Magnetoliposomes for controlled drug release in the presence of low-frequency magnetic field. Soft Matter 6: 154–162. Available: http://dx.doi.org/10.1039/b915651h.
Publisher:
Royal Society of Chemistry (RSC)
Journal:
Soft Matter
Issue Date:
2010
DOI:
10.1039/b915651h
Type:
Article
ISSN:
1744-683X; 1744-6848
Sponsors:
Financial support from CSGI, MIUR-PRIN 2006 and the
Appears in Collections:
Publications Acknowledging KAUST Support

Full metadata record

DC FieldValue Language
dc.contributor.authorNappini, Silviaen
dc.contributor.authorBombelli, Francesca Baldellien
dc.contributor.authorBonini, Massimoen
dc.contributor.authorNordèn, Bengten
dc.contributor.authorBaglioni, Pieroen
dc.date.accessioned2016-02-25T13:40:29Zen
dc.date.available2016-02-25T13:40:29Zen
dc.date.issued2010en
dc.identifier.citationNappini S, Bombelli FB, Bonini M, Nordèn B, Baglioni P (2010) Magnetoliposomes for controlled drug release in the presence of low-frequency magnetic field. Soft Matter 6: 154–162. Available: http://dx.doi.org/10.1039/b915651h.en
dc.identifier.issn1744-683Xen
dc.identifier.issn1744-6848en
dc.identifier.doi10.1039/b915651hen
dc.identifier.urihttp://hdl.handle.net/10754/598751en
dc.description.abstractIn this work we have studied the effect of a low-frequency alternating magnetic field (LF-AMF) on the permeability of magnetoliposomes, i.e. liposomes including magnetic nanoparticles within their water pool. Large unilamellar liposomes loaded with magnetic cobalt ferrite nanoparticles (CoFe 2O4) have been prepared and characterized. Structural characterization of the liposomal dispersion has been performed by dynamic light scattering (DLS). The enhancement of liposome permeability upon exposure to LF-AMF has been measured as the self-quenching decrease of a fluorescent hydrophilic molecule (carboxyfluorescein, CF) entrapped in the liposome pool. Liposome leakage has been monitored as a function of field frequency, time of exposure and concentration, charge and size of the embedded nanoparticles. The results show that CF release from magnetoliposomes is strongly promoted by LF-AMF, reasonably as a consequence of nanoparticle motions in the liposome pool at the applied frequency. CF release as a function of time in magnetoliposomes unexposed to magnetic field follows Fickian diffusion, while samples exposed to LF-AMF show zero-order kinetics, consistently with an anomalous transport, due to an alteration of the bilayer permeability. These preliminary results open up new perspectives in the use of these systems as carriers in targeted and controlled release of drugs. © The Royal Society of Chemistry 2010.en
dc.description.sponsorshipFinancial support from CSGI, MIUR-PRIN 2006 and theen
dc.publisherRoyal Society of Chemistry (RSC)en
dc.titleMagnetoliposomes for controlled drug release in the presence of low-frequency magnetic fielden
dc.typeArticleen
dc.identifier.journalSoft Matteren
dc.contributor.institutionUniversita degli Studi di Firenze, Florence, Italyen
dc.contributor.institutionChalmers University of Technology, Göteborg, Swedenen
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