Highly Defined Multiblock Copolypeptoids: Pushing the Limits of Living Nucleophilic Ring-Opening Polymerization

Handle URI:
http://hdl.handle.net/10754/598502
Title:
Highly Defined Multiblock Copolypeptoids: Pushing the Limits of Living Nucleophilic Ring-Opening Polymerization
Authors:
Fetsch, Corinna; Luxenhofer, Robert
Abstract:
Advanced macromolecular engineering requires excellent control over the polymerization reaction. Living polymerization methods are notoriously sensitive to impurities, which makes a practical realization of such control very challenging. Reversible-deactivation radical polymerization methods are typically more robust, but have other limitations. Here, we demonstrate by repeated (ge;10 times) chain extension the extraordinary robustness of the living nucleophilic ring-opening polymerization of N-substituted glycine N-carboxyanhydrides, which yields polypeptoids. We observe essentially quantitative end-group fidelity under experimental conditions that are comparatively easily managed. This is employed to synthesize a pentablock quinquiespolymer with high definition. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Citation:
Fetsch C, Luxenhofer R (2012) Highly Defined Multiblock Copolypeptoids: Pushing the Limits of Living Nucleophilic Ring-Opening Polymerization. Macromolecular Rapid Communications 33: 1708–1713. Available: http://dx.doi.org/10.1002/marc.201200189.
Publisher:
Wiley-Blackwell
Journal:
Macromolecular Rapid Communications
KAUST Grant Number:
KUK-F1-029-32
Issue Date:
5-Jun-2012
DOI:
10.1002/marc.201200189
PubMed ID:
22674859
Type:
Article
ISSN:
1022-1336
Sponsors:
This publication is based on work supported by Award No. KUK-F1-029-32, made by King Abdullah University of Science and Technology (KAUST).
Appears in Collections:
Publications Acknowledging KAUST Support

Full metadata record

DC FieldValue Language
dc.contributor.authorFetsch, Corinnaen
dc.contributor.authorLuxenhofer, Roberten
dc.date.accessioned2016-02-25T13:31:08Zen
dc.date.available2016-02-25T13:31:08Zen
dc.date.issued2012-06-05en
dc.identifier.citationFetsch C, Luxenhofer R (2012) Highly Defined Multiblock Copolypeptoids: Pushing the Limits of Living Nucleophilic Ring-Opening Polymerization. Macromolecular Rapid Communications 33: 1708–1713. Available: http://dx.doi.org/10.1002/marc.201200189.en
dc.identifier.issn1022-1336en
dc.identifier.pmid22674859en
dc.identifier.doi10.1002/marc.201200189en
dc.identifier.urihttp://hdl.handle.net/10754/598502en
dc.description.abstractAdvanced macromolecular engineering requires excellent control over the polymerization reaction. Living polymerization methods are notoriously sensitive to impurities, which makes a practical realization of such control very challenging. Reversible-deactivation radical polymerization methods are typically more robust, but have other limitations. Here, we demonstrate by repeated (ge;10 times) chain extension the extraordinary robustness of the living nucleophilic ring-opening polymerization of N-substituted glycine N-carboxyanhydrides, which yields polypeptoids. We observe essentially quantitative end-group fidelity under experimental conditions that are comparatively easily managed. This is employed to synthesize a pentablock quinquiespolymer with high definition. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.en
dc.description.sponsorshipThis publication is based on work supported by Award No. KUK-F1-029-32, made by King Abdullah University of Science and Technology (KAUST).en
dc.publisherWiley-Blackwellen
dc.subjectbiomaterialsen
dc.subjectend-group fidelityen
dc.subjectliving polymerizationen
dc.subjectmultiblock copolymersen
dc.subjectpeptoiden
dc.titleHighly Defined Multiblock Copolypeptoids: Pushing the Limits of Living Nucleophilic Ring-Opening Polymerizationen
dc.typeArticleen
dc.identifier.journalMacromolecular Rapid Communicationsen
dc.contributor.institutionTechnische Universitat Dresden, Dresden, Germanyen
kaust.grant.numberKUK-F1-029-32en
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