Highly Aminated Mesoporous Silica Nanoparticles with Cubic Pore Structure

Handle URI:
http://hdl.handle.net/10754/598498
Title:
Highly Aminated Mesoporous Silica Nanoparticles with Cubic Pore Structure
Authors:
Suteewong, Teeraporn; Sai, Hiroaki; Cohen, Roy; Wang, Suntao; Bradbury, Michelle; Baird, Barbara; Gruner, Sol M.; Wiesner, Ulrich
Abstract:
Mesoporous silica with cubic symmetry has attracted interest from researchers for some time. Here, we present the room temperature synthesis of mesoporous silica nanoparticles possessing cubic Pm3n symmetry with very high molar ratios (>50%) of 3-aminopropyl triethoxysilane. The synthesis is robust allowing, for example, co-condensation of organic dyes without loss of structure. By means of pore expander molecules, the pore size can be enlarged from 2.7 to 5 nm, while particle size decreases. Adding pore expander and co-condensing fluorescent dyes in the same synthesis reduces average particle size further down to 100 nm. After PEGylation, such fluorescent aminated mesoporous silica nanoparticles are spontaneously taken up by cells as demonstrated by fluorescence microscopy.
Citation:
Suteewong T, Sai H, Cohen R, Wang S, Bradbury M, et al. (2011) Highly Aminated Mesoporous Silica Nanoparticles with Cubic Pore Structure. Journal of the American Chemical Society 133: 172–175. Available: http://dx.doi.org/10.1021/ja1061664.
Publisher:
American Chemical Society (ACS)
Journal:
Journal of the American Chemical Society
Issue Date:
19-Jan-2011
DOI:
10.1021/ja1061664
PubMed ID:
21158438
PubMed Central ID:
PMC3084371
Type:
Article
ISSN:
0002-7863; 1520-5126
Sponsors:
This work was supported by the Cornell Center for Materials Research (CCMR) with funding from a PREM program at Norfolk State University through the National Science Foundation (NSF) grant (DMR-0611430), by the Department of Energy grant DE-FG02-97ER62443 and by the National Institute of Dental and Craniofacial Research (R21DE018335). We thank the Cornell Universiy KAUST Center for Research and Education for financial support. This work was further supported by the U.S. Department of Homeland Security under Cooperative Agreement Number "2009-ST-108-LR0004". The authors thank CCMR for facility support. This work is based upon research conducted at the Cornell High Energy Synchrotron Source (CHESS), which is supported by the NSF and the National Institutes of Health/National Institute of General Medical Sciences under NSF award DMR-0225180. T.S. is grateful for a Thai Government Scholarship tinder the Ministry of Science and Technology.
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Full metadata record

DC FieldValue Language
dc.contributor.authorSuteewong, Teerapornen
dc.contributor.authorSai, Hiroakien
dc.contributor.authorCohen, Royen
dc.contributor.authorWang, Suntaoen
dc.contributor.authorBradbury, Michelleen
dc.contributor.authorBaird, Barbaraen
dc.contributor.authorGruner, Sol M.en
dc.contributor.authorWiesner, Ulrichen
dc.date.accessioned2016-02-25T13:31:04Zen
dc.date.available2016-02-25T13:31:04Zen
dc.date.issued2011-01-19en
dc.identifier.citationSuteewong T, Sai H, Cohen R, Wang S, Bradbury M, et al. (2011) Highly Aminated Mesoporous Silica Nanoparticles with Cubic Pore Structure. Journal of the American Chemical Society 133: 172–175. Available: http://dx.doi.org/10.1021/ja1061664.en
dc.identifier.issn0002-7863en
dc.identifier.issn1520-5126en
dc.identifier.pmid21158438en
dc.identifier.doi10.1021/ja1061664en
dc.identifier.urihttp://hdl.handle.net/10754/598498en
dc.description.abstractMesoporous silica with cubic symmetry has attracted interest from researchers for some time. Here, we present the room temperature synthesis of mesoporous silica nanoparticles possessing cubic Pm3n symmetry with very high molar ratios (>50%) of 3-aminopropyl triethoxysilane. The synthesis is robust allowing, for example, co-condensation of organic dyes without loss of structure. By means of pore expander molecules, the pore size can be enlarged from 2.7 to 5 nm, while particle size decreases. Adding pore expander and co-condensing fluorescent dyes in the same synthesis reduces average particle size further down to 100 nm. After PEGylation, such fluorescent aminated mesoporous silica nanoparticles are spontaneously taken up by cells as demonstrated by fluorescence microscopy.en
dc.description.sponsorshipThis work was supported by the Cornell Center for Materials Research (CCMR) with funding from a PREM program at Norfolk State University through the National Science Foundation (NSF) grant (DMR-0611430), by the Department of Energy grant DE-FG02-97ER62443 and by the National Institute of Dental and Craniofacial Research (R21DE018335). We thank the Cornell Universiy KAUST Center for Research and Education for financial support. This work was further supported by the U.S. Department of Homeland Security under Cooperative Agreement Number "2009-ST-108-LR0004". The authors thank CCMR for facility support. This work is based upon research conducted at the Cornell High Energy Synchrotron Source (CHESS), which is supported by the NSF and the National Institutes of Health/National Institute of General Medical Sciences under NSF award DMR-0225180. T.S. is grateful for a Thai Government Scholarship tinder the Ministry of Science and Technology.en
dc.publisherAmerican Chemical Society (ACS)en
dc.titleHighly Aminated Mesoporous Silica Nanoparticles with Cubic Pore Structureen
dc.typeArticleen
dc.identifier.journalJournal of the American Chemical Societyen
dc.identifier.pmcidPMC3084371en
dc.contributor.institutionDepartment of Materials Science and Engineering, Cornell University, Ithaca, New York 14853, United States.en

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