Functionalized Nanostructures: Redox-Active Porphyrin Anchors for Supramolecular DNA Assemblies

Handle URI:
http://hdl.handle.net/10754/598387
Title:
Functionalized Nanostructures: Redox-Active Porphyrin Anchors for Supramolecular DNA Assemblies
Authors:
Börjesson, Karl; Wiberg, Joanna; El-Sagheer, Afaf H.; Ljungdahl, Thomas; Mårtensson, Jerker; Brown, Tom; Nordén, Bengt; Albinsson, Bo
Abstract:
We have synthesized and studied a supramolecular system comprising a 39-mer DNA with porphyrin-modified thymidine nucleosides anchored to the surface of large unilamellar vesicles (liposomes). Liposome porphyrin binding characteristics, such as orientation, strength, homogeneity, and binding site size, was determined, suggesting that the porphyrin is well suited as a photophysical and redox-active lipid anchor, in comparison to the inert cholesterol anchor commonly used today. Furthermore, the binding characteristics and hybridization capabilities were studied as a function of anchor size and number of anchoring points, properties that are of importance for our future plans to use the addressability of these redox-active nodes in larger DNA-based nanoconstructs. Electron transfer from photoexcited porphyrin to a lipophilic benzoquinone residing in the lipid membrane was characterized by steady-state and time-resolved fluorescence and verified by femtosecond transient absorption. © 2010 American Chemical Society.
Citation:
Börjesson K, Wiberg J, El-Sagheer AH, Ljungdahl T, Mårtensson J, et al. (2010) Functionalized Nanostructures: Redox-Active Porphyrin Anchors for Supramolecular DNA Assemblies. ACS Nano 4: 5037–5046. Available: http://dx.doi.org/10.1021/nn100667b.
Publisher:
American Chemical Society (ACS)
Journal:
ACS Nano
Issue Date:
28-Sep-2010
DOI:
10.1021/nn100667b
PubMed ID:
20809571
Type:
Article
ISSN:
1936-0851; 1936-086X
Sponsors:
This research is founded by King Abdullah University of Science and Technology, The Swedish Research Council (VR), The Swedish Energy Agency, and Knut and Alice Wallenbergs Foundation.
Appears in Collections:
Publications Acknowledging KAUST Support

Full metadata record

DC FieldValue Language
dc.contributor.authorBörjesson, Karlen
dc.contributor.authorWiberg, Joannaen
dc.contributor.authorEl-Sagheer, Afaf H.en
dc.contributor.authorLjungdahl, Thomasen
dc.contributor.authorMårtensson, Jerkeren
dc.contributor.authorBrown, Tomen
dc.contributor.authorNordén, Bengten
dc.contributor.authorAlbinsson, Boen
dc.date.accessioned2016-02-25T13:19:51Zen
dc.date.available2016-02-25T13:19:51Zen
dc.date.issued2010-09-28en
dc.identifier.citationBörjesson K, Wiberg J, El-Sagheer AH, Ljungdahl T, Mårtensson J, et al. (2010) Functionalized Nanostructures: Redox-Active Porphyrin Anchors for Supramolecular DNA Assemblies. ACS Nano 4: 5037–5046. Available: http://dx.doi.org/10.1021/nn100667b.en
dc.identifier.issn1936-0851en
dc.identifier.issn1936-086Xen
dc.identifier.pmid20809571en
dc.identifier.doi10.1021/nn100667ben
dc.identifier.urihttp://hdl.handle.net/10754/598387en
dc.description.abstractWe have synthesized and studied a supramolecular system comprising a 39-mer DNA with porphyrin-modified thymidine nucleosides anchored to the surface of large unilamellar vesicles (liposomes). Liposome porphyrin binding characteristics, such as orientation, strength, homogeneity, and binding site size, was determined, suggesting that the porphyrin is well suited as a photophysical and redox-active lipid anchor, in comparison to the inert cholesterol anchor commonly used today. Furthermore, the binding characteristics and hybridization capabilities were studied as a function of anchor size and number of anchoring points, properties that are of importance for our future plans to use the addressability of these redox-active nodes in larger DNA-based nanoconstructs. Electron transfer from photoexcited porphyrin to a lipophilic benzoquinone residing in the lipid membrane was characterized by steady-state and time-resolved fluorescence and verified by femtosecond transient absorption. © 2010 American Chemical Society.en
dc.description.sponsorshipThis research is founded by King Abdullah University of Science and Technology, The Swedish Research Council (VR), The Swedish Energy Agency, and Knut and Alice Wallenbergs Foundation.en
dc.publisherAmerican Chemical Society (ACS)en
dc.subjectDNAen
dc.subjectelectron transferen
dc.subjectmembraneen
dc.subjectnanotechnologyen
dc.subjectporphyrinen
dc.subjectsupramolecularen
dc.titleFunctionalized Nanostructures: Redox-Active Porphyrin Anchors for Supramolecular DNA Assembliesen
dc.typeArticleen
dc.identifier.journalACS Nanoen
dc.contributor.institutionChalmers University of Technology, Göteborg, Swedenen
dc.contributor.institutionUniversity of Southampton, Southampton, United Kingdomen
dc.contributor.institutionSuez Canal University, Ismalia, Egypten
dc.contributor.institutionGoteborgs Universitet, Goteborg, Swedenen

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