Evaluation of template-based models in CASP8 with standard measures

Handle URI:
http://hdl.handle.net/10754/598255
Title:
Evaluation of template-based models in CASP8 with standard measures
Authors:
Cozzetto, Domenico; Kryshtafovych, Andriy; Fidelis, Krzysztof; Moult, John; Rost, Burkhard; Tramontano, Anna
Abstract:
The strategy for evaluating template-based models submitted to CASP has continuously evolved from CASP1 to CASP5, leading to a standard procedure that has been used in all subsequent editions. The established approach includes methods for calculating the quality of each individual model, for assigning scores based on the distribution of the results for each target and for computing the statistical significance of the differences in scores between prediction methods. These data are made available to the assessor of the template-based modeling category, who uses them as a starting point for further evaluations and analyses. This article describes the detailed workflow of the procedure, provides justifications for a number of choices that are customarily made for CASP data evaluation, and reports the results of the analysis of template-based predictions at CASP8.
Citation:
Cozzetto D, Kryshtafovych A, Fidelis K, Moult J, Rost B, et al. (2009) Evaluation of template-based models in CASP8 with standard measures. Proteins: Structure, Function, and Bioinformatics 77: 18–28. Available: http://dx.doi.org/10.1002/prot.22561.
Publisher:
Wiley-Blackwell
Journal:
Proteins: Structure, Function, and Bioinformatics
KAUST Grant Number:
KUK-11-012-43
Issue Date:
2009
DOI:
10.1002/prot.22561
PubMed ID:
19731382
PubMed Central ID:
PMC4589151
Type:
Article
ISSN:
0887-3585
Sponsors:
Grant sponsor: The US National Library of Medicine (NIH/NLM); Grant number: LM-07085; Grant sponsor: KAUST Grant number: KUK-11-012-43; Grant sponsor: EMBO; Grant sponsor: Italbionet (MIUR).
Appears in Collections:
Publications Acknowledging KAUST Support

Full metadata record

DC FieldValue Language
dc.contributor.authorCozzetto, Domenicoen
dc.contributor.authorKryshtafovych, Andriyen
dc.contributor.authorFidelis, Krzysztofen
dc.contributor.authorMoult, Johnen
dc.contributor.authorRost, Burkharden
dc.contributor.authorTramontano, Annaen
dc.date.accessioned2016-02-25T13:17:29Zen
dc.date.available2016-02-25T13:17:29Zen
dc.date.issued2009en
dc.identifier.citationCozzetto D, Kryshtafovych A, Fidelis K, Moult J, Rost B, et al. (2009) Evaluation of template-based models in CASP8 with standard measures. Proteins: Structure, Function, and Bioinformatics 77: 18–28. Available: http://dx.doi.org/10.1002/prot.22561.en
dc.identifier.issn0887-3585en
dc.identifier.pmid19731382en
dc.identifier.doi10.1002/prot.22561en
dc.identifier.urihttp://hdl.handle.net/10754/598255en
dc.description.abstractThe strategy for evaluating template-based models submitted to CASP has continuously evolved from CASP1 to CASP5, leading to a standard procedure that has been used in all subsequent editions. The established approach includes methods for calculating the quality of each individual model, for assigning scores based on the distribution of the results for each target and for computing the statistical significance of the differences in scores between prediction methods. These data are made available to the assessor of the template-based modeling category, who uses them as a starting point for further evaluations and analyses. This article describes the detailed workflow of the procedure, provides justifications for a number of choices that are customarily made for CASP data evaluation, and reports the results of the analysis of template-based predictions at CASP8.en
dc.description.sponsorshipGrant sponsor: The US National Library of Medicine (NIH/NLM); Grant number: LM-07085; Grant sponsor: KAUST Grant number: KUK-11-012-43; Grant sponsor: EMBO; Grant sponsor: Italbionet (MIUR).en
dc.publisherWiley-Blackwellen
dc.subjectCASPen
dc.subjectNumerical evaluation measuresen
dc.subjectProtein structure predictionen
dc.subjectTemplate-based protein modelingen
dc.subject.meshModels, Molecularen
dc.titleEvaluation of template-based models in CASP8 with standard measuresen
dc.typeArticleen
dc.identifier.journalProteins: Structure, Function, and Bioinformaticsen
dc.identifier.pmcidPMC4589151en
dc.contributor.institutionDepartment of Biochemical Sciences, Sapienza-University of Rome, P. A. Moro, 5, 00185 Rome, Italy.en
kaust.grant.numberKUK-11-012-43en

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