Handle URI:
http://hdl.handle.net/10754/598253
Title:
Evaluation of residue-residue contact predictions in CASP9
Authors:
Monastyrskyy, Bohdan; Fidelis, Krzysztof; Tramontano, Anna; Kryshtafovych, Andriy
Abstract:
This work presents the results of the assessment of the intramolecular residue-residue contact predictions submitted to CASP9. The methodology for the assessment does not differ from that used in previous CASPs, with two basic evaluation measures being the precision in recognizing contacts and the difference between the distribution of distances in the subset of predicted contact pairs versus all pairs of residues in the structure. The emphasis is placed on the prediction of long-range contacts (i.e., contacts between residues separated by at least 24 residues along sequence) in target proteins that cannot be easily modeled by homology. Although there is considerable activity in the field, the current analysis reports no discernable progress since CASP8.
Citation:
Monastyrskyy B, Fidelis K, Tramontano A, Kryshtafovych A (2011) Evaluation of residue-residue contact predictions in CASP9. Proteins: Structure, Function, and Bioinformatics 79: 119–125. Available: http://dx.doi.org/10.1002/prot.23160.
Publisher:
Wiley-Blackwell
Journal:
Proteins: Structure, Function, and Bioinformatics
KAUST Grant Number:
KUK-I1-012-43
Issue Date:
2011
DOI:
10.1002/prot.23160
PubMed ID:
21928322
PubMed Central ID:
PMC3226919
Type:
Article
ISSN:
0887-3585
Sponsors:
Grant sponsor: National Library of Medicine (NIH/NLM); Grant number: LM007085; Grant sponsor: KAUST Award; Grant number: KUK-I1-012-43.
Appears in Collections:
Publications Acknowledging KAUST Support

Full metadata record

DC FieldValue Language
dc.contributor.authorMonastyrskyy, Bohdanen
dc.contributor.authorFidelis, Krzysztofen
dc.contributor.authorTramontano, Annaen
dc.contributor.authorKryshtafovych, Andriyen
dc.date.accessioned2016-02-25T13:17:27Zen
dc.date.available2016-02-25T13:17:27Zen
dc.date.issued2011en
dc.identifier.citationMonastyrskyy B, Fidelis K, Tramontano A, Kryshtafovych A (2011) Evaluation of residue-residue contact predictions in CASP9. Proteins: Structure, Function, and Bioinformatics 79: 119–125. Available: http://dx.doi.org/10.1002/prot.23160.en
dc.identifier.issn0887-3585en
dc.identifier.pmid21928322en
dc.identifier.doi10.1002/prot.23160en
dc.identifier.urihttp://hdl.handle.net/10754/598253en
dc.description.abstractThis work presents the results of the assessment of the intramolecular residue-residue contact predictions submitted to CASP9. The methodology for the assessment does not differ from that used in previous CASPs, with two basic evaluation measures being the precision in recognizing contacts and the difference between the distribution of distances in the subset of predicted contact pairs versus all pairs of residues in the structure. The emphasis is placed on the prediction of long-range contacts (i.e., contacts between residues separated by at least 24 residues along sequence) in target proteins that cannot be easily modeled by homology. Although there is considerable activity in the field, the current analysis reports no discernable progress since CASP8.en
dc.description.sponsorshipGrant sponsor: National Library of Medicine (NIH/NLM); Grant number: LM007085; Grant sponsor: KAUST Award; Grant number: KUK-I1-012-43.en
dc.publisherWiley-Blackwellen
dc.subjectCASPen
dc.subjectIntramolecular contactsen
dc.subjectProtein structure modelingen
dc.subjectResidue-residue contact predictionen
dc.subject.meshModels, Molecularen
dc.titleEvaluation of residue-residue contact predictions in CASP9en
dc.typeArticleen
dc.identifier.journalProteins: Structure, Function, and Bioinformaticsen
dc.identifier.pmcidPMC3226919en
dc.contributor.institutionGenome Center, University of California-Davis, 451 Health Sciences Drive, Davis, CA 95616, USAen
kaust.grant.numberKUK-I1-012-43en

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