Local synaptic signaling enhances the stochastic transport of motor-driven cargo in neurons

Handle URI:
http://hdl.handle.net/10754/598225
Title:
Local synaptic signaling enhances the stochastic transport of motor-driven cargo in neurons
Authors:
Newby, Jay; Bressloff, Paul C
Abstract:
The tug-of-war model of motor-driven cargo transport is formulated as an intermittent trapping process. An immobile trap, representing the cellular machinery that sequesters a motor-driven cargo for eventual use, is located somewhere within a microtubule track. A particle representing a motor-driven cargo that moves randomly with a forward bias is introduced at the beginning of the track. The particle switches randomly between a fast moving phase and a slow moving phase. When in the slow moving phase, the particle can be captured by the trap. To account for the possibility that the particle avoids the trap, an absorbing boundary is placed at the end of the track. Two local signaling mechanisms-intended to improve the chances of capturing the target-are considered by allowing the trap to affect the tug-of-war parameters within a small region around itself. The first is based on a localized adenosine triphosphate (ATP) concentration gradient surrounding a synapse, and the second is based on a concentration of tau-a microtubule-associated protein involved in Alzheimer's disease-coating the microtubule near the synapse. It is shown that both mechanisms can lead to dramatic improvements in the capture probability, with a minimal increase in the mean capture time. The analysis also shows that tau can cause a cargo to undergo random oscillations, which could explain some experimental observations. © 2010 IOP Publishing Ltd.
Citation:
Newby J, Bressloff PC (2010) Local synaptic signaling enhances the stochastic transport of motor-driven cargo in neurons. Physical Biology 7: 036004. Available: http://dx.doi.org/10.1088/1478-3975/7/3/036004.
Publisher:
IOP Publishing
Journal:
Physical Biology
KAUST Grant Number:
KUK-C1-013-4
Issue Date:
23-Aug-2010
DOI:
10.1088/1478-3975/7/3/036004
PubMed ID:
20733246
Type:
Article
ISSN:
1478-3975
Sponsors:
This publication was based on work supported in part by the NSF (DMS-0813677) and by Award No KUK-C1-013-4 made by King Abdullah University of Science and Technology (KAUST). PCB was also partially supported by the Royal Society-Wolfson Foundation.
Appears in Collections:
Publications Acknowledging KAUST Support

Full metadata record

DC FieldValue Language
dc.contributor.authorNewby, Jayen
dc.contributor.authorBressloff, Paul Cen
dc.date.accessioned2016-02-25T13:39:57Zen
dc.date.available2016-02-25T13:39:57Zen
dc.date.issued2010-08-23en
dc.identifier.citationNewby J, Bressloff PC (2010) Local synaptic signaling enhances the stochastic transport of motor-driven cargo in neurons. Physical Biology 7: 036004. Available: http://dx.doi.org/10.1088/1478-3975/7/3/036004.en
dc.identifier.issn1478-3975en
dc.identifier.pmid20733246en
dc.identifier.doi10.1088/1478-3975/7/3/036004en
dc.identifier.urihttp://hdl.handle.net/10754/598225en
dc.description.abstractThe tug-of-war model of motor-driven cargo transport is formulated as an intermittent trapping process. An immobile trap, representing the cellular machinery that sequesters a motor-driven cargo for eventual use, is located somewhere within a microtubule track. A particle representing a motor-driven cargo that moves randomly with a forward bias is introduced at the beginning of the track. The particle switches randomly between a fast moving phase and a slow moving phase. When in the slow moving phase, the particle can be captured by the trap. To account for the possibility that the particle avoids the trap, an absorbing boundary is placed at the end of the track. Two local signaling mechanisms-intended to improve the chances of capturing the target-are considered by allowing the trap to affect the tug-of-war parameters within a small region around itself. The first is based on a localized adenosine triphosphate (ATP) concentration gradient surrounding a synapse, and the second is based on a concentration of tau-a microtubule-associated protein involved in Alzheimer's disease-coating the microtubule near the synapse. It is shown that both mechanisms can lead to dramatic improvements in the capture probability, with a minimal increase in the mean capture time. The analysis also shows that tau can cause a cargo to undergo random oscillations, which could explain some experimental observations. © 2010 IOP Publishing Ltd.en
dc.description.sponsorshipThis publication was based on work supported in part by the NSF (DMS-0813677) and by Award No KUK-C1-013-4 made by King Abdullah University of Science and Technology (KAUST). PCB was also partially supported by the Royal Society-Wolfson Foundation.en
dc.publisherIOP Publishingen
dc.titleLocal synaptic signaling enhances the stochastic transport of motor-driven cargo in neuronsen
dc.typeArticleen
dc.identifier.journalPhysical Biologyen
dc.contributor.institutionUniversity of Utah, Salt Lake City, United Statesen
dc.contributor.institutionUniversity of Oxford, Oxford, United Kingdomen
kaust.grant.numberKUK-C1-013-4en

Related articles on PubMed

All Items in KAUST are protected by copyright, with all rights reserved, unless otherwise indicated.