Entropy-enthalpy compensation may be a useful interpretation tool for complex systems like protein-DNA complexes: An appeal to experimentalists

Handle URI:
http://hdl.handle.net/10754/598203
Title:
Entropy-enthalpy compensation may be a useful interpretation tool for complex systems like protein-DNA complexes: An appeal to experimentalists
Authors:
Starikov, E. B.; Nordén, B.
Abstract:
In various chemical systems, enthalpy-entropy compensation (EEC) is a well-known rule of behavior, although the physical roots of it are still not completely understood. It has been frequently questioned whether EEC is a truly physical phenomenon or a coincidence due to trivial mathematical connections between statistical-mechanical parameters-or even simpler: A phantom effect resulting from the misinterpretation of experimental data. Here, we review EEC from another standpoint using the notion of correlation, which is essential for the method of factor analysis but is not conventional in physics and chemistry. We conclude that the EEC may be rationalized in terms of hidden (not directly measurable with the help of the current experimental set-up) but physically real factors, implying a Carnot-cycle model in which a micro-phase transition (MPT) plays a crucial role. Examples of such MPTs underlying physically valid EEC should be typically cooperative processes in supramolecular aggregates, like changes of structured water at hydrophobic surfaces, conformational transitions upon ligand-biopolymer binding, and so on. The MPT notion could help rationalize the occurrence of EEC in connection with hydration and folding of proteins, enzymatic reactions, functioning of molecular motors, DNA de- and rehybridization, as well as similar phenomena. © 2012 American Institute of Physics.
Citation:
Starikov EB, Nordén B (2012) Entropy-enthalpy compensation may be a useful interpretation tool for complex systems like protein-DNA complexes: An appeal to experimentalists. Applied Physics Letters 100: 193701. Available: http://dx.doi.org/10.1063/1.4714726.
Publisher:
AIP Publishing
Journal:
Applied Physics Letters
Issue Date:
2012
DOI:
10.1063/1.4714726
Type:
Article
ISSN:
0003-6951
Sponsors:
B.N. would like to acknowledge financial support from King Abdullah University of Science and Technology (KAUST).
Appears in Collections:
Publications Acknowledging KAUST Support

Full metadata record

DC FieldValue Language
dc.contributor.authorStarikov, E. B.en
dc.contributor.authorNordén, B.en
dc.date.accessioned2016-02-25T13:14:38Zen
dc.date.available2016-02-25T13:14:38Zen
dc.date.issued2012en
dc.identifier.citationStarikov EB, Nordén B (2012) Entropy-enthalpy compensation may be a useful interpretation tool for complex systems like protein-DNA complexes: An appeal to experimentalists. Applied Physics Letters 100: 193701. Available: http://dx.doi.org/10.1063/1.4714726.en
dc.identifier.issn0003-6951en
dc.identifier.doi10.1063/1.4714726en
dc.identifier.urihttp://hdl.handle.net/10754/598203en
dc.description.abstractIn various chemical systems, enthalpy-entropy compensation (EEC) is a well-known rule of behavior, although the physical roots of it are still not completely understood. It has been frequently questioned whether EEC is a truly physical phenomenon or a coincidence due to trivial mathematical connections between statistical-mechanical parameters-or even simpler: A phantom effect resulting from the misinterpretation of experimental data. Here, we review EEC from another standpoint using the notion of correlation, which is essential for the method of factor analysis but is not conventional in physics and chemistry. We conclude that the EEC may be rationalized in terms of hidden (not directly measurable with the help of the current experimental set-up) but physically real factors, implying a Carnot-cycle model in which a micro-phase transition (MPT) plays a crucial role. Examples of such MPTs underlying physically valid EEC should be typically cooperative processes in supramolecular aggregates, like changes of structured water at hydrophobic surfaces, conformational transitions upon ligand-biopolymer binding, and so on. The MPT notion could help rationalize the occurrence of EEC in connection with hydration and folding of proteins, enzymatic reactions, functioning of molecular motors, DNA de- and rehybridization, as well as similar phenomena. © 2012 American Institute of Physics.en
dc.description.sponsorshipB.N. would like to acknowledge financial support from King Abdullah University of Science and Technology (KAUST).en
dc.publisherAIP Publishingen
dc.titleEntropy-enthalpy compensation may be a useful interpretation tool for complex systems like protein-DNA complexes: An appeal to experimentalistsen
dc.typeArticleen
dc.identifier.journalApplied Physics Lettersen
dc.contributor.institutionTechnische Universitat Dresden, Dresden, Germanyen
dc.contributor.institutionChalmers University of Technology, Göteborg, Swedenen
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