Enantiospecific kinking of DNA by a partially intercalating metal complex

Handle URI:
http://hdl.handle.net/10754/598163
Title:
Enantiospecific kinking of DNA by a partially intercalating metal complex
Authors:
Reymer, Anna; Nordén, Bengt
Abstract:
Opposite enantiomers of [Ru(phenanthroline) 3] 2+ affect the persistence length of DNA differently, a long speculated effect of helix kinking. Our molecular dynamics simulations confirm a substantial change of duplex secondary structure produced by wedge-intercalation of one but not the other enantiomer. This effect is exploited by several classes of DNA operative proteins. © The Royal Society of Chemistry 2012.
Citation:
Reymer A, Nordén B (2012) Enantiospecific kinking of DNA by a partially intercalating metal complex. Chem Commun 48: 4941. Available: http://dx.doi.org/10.1039/c2cc31176c.
Publisher:
Royal Society of Chemistry (RSC)
Journal:
Chemical Communications
KAUST Grant Number:
KUK-11-008-23
Issue Date:
2012
DOI:
10.1039/c2cc31176c
PubMed ID:
22476247
Type:
Article
ISSN:
1359-7345; 1364-548X
Sponsors:
This work was supported by King Abdullah University of Science and Technology, Grant [KUK-11-008-23] awarded to B.N.
Appears in Collections:
Publications Acknowledging KAUST Support

Full metadata record

DC FieldValue Language
dc.contributor.authorReymer, Annaen
dc.contributor.authorNordén, Bengten
dc.date.accessioned2016-02-25T13:13:53Zen
dc.date.available2016-02-25T13:13:53Zen
dc.date.issued2012en
dc.identifier.citationReymer A, Nordén B (2012) Enantiospecific kinking of DNA by a partially intercalating metal complex. Chem Commun 48: 4941. Available: http://dx.doi.org/10.1039/c2cc31176c.en
dc.identifier.issn1359-7345en
dc.identifier.issn1364-548Xen
dc.identifier.pmid22476247en
dc.identifier.doi10.1039/c2cc31176cen
dc.identifier.urihttp://hdl.handle.net/10754/598163en
dc.description.abstractOpposite enantiomers of [Ru(phenanthroline) 3] 2+ affect the persistence length of DNA differently, a long speculated effect of helix kinking. Our molecular dynamics simulations confirm a substantial change of duplex secondary structure produced by wedge-intercalation of one but not the other enantiomer. This effect is exploited by several classes of DNA operative proteins. © The Royal Society of Chemistry 2012.en
dc.description.sponsorshipThis work was supported by King Abdullah University of Science and Technology, Grant [KUK-11-008-23] awarded to B.N.en
dc.publisherRoyal Society of Chemistry (RSC)en
dc.titleEnantiospecific kinking of DNA by a partially intercalating metal complexen
dc.typeArticleen
dc.identifier.journalChemical Communicationsen
dc.contributor.institutionChalmers University of Technology, Göteborg, Swedenen
kaust.grant.numberKUK-11-008-23en
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