Critical assessment of methods of protein structure prediction (CASP)-round IX

Handle URI:
http://hdl.handle.net/10754/597895
Title:
Critical assessment of methods of protein structure prediction (CASP)-round IX
Authors:
Moult, John; Fidelis, Krzysztof; Kryshtafovych, Andriy; Tramontano, Anna
Abstract:
This article is an introduction to the special issue of the journal PROTEINS, dedicated to the ninth Critical Assessment of Structure Prediction (CASP) experiment to assess the state of the art in protein structure modeling. The article describes the conduct of the experiment, the categories of prediction included, and outlines the evaluation and assessment procedures. Methods for modeling protein structure continue to advance, although at a more modest pace than in the early CASP experiments. CASP developments of note are indications of improvement in model accuracy for some classes of target, an improved ability to choose the most accurate of a set of generated models, and evidence of improvement in accuracy for short "new fold" models. In addition, a new analysis of regions of models not derivable from the most obvious template structure has revealed better performance than expected.
Citation:
Moult J, Fidelis K, Kryshtafovych A, Tramontano A (2011) Critical assessment of methods of protein structure prediction (CASP)-round IX. Proteins: Structure, Function, and Bioinformatics 79: 1–5. Available: http://dx.doi.org/10.1002/prot.23200.
Publisher:
Wiley-Blackwell
Journal:
Proteins: Structure, Function, and Bioinformatics
KAUST Grant Number:
KUK-I1-012-43
Issue Date:
2011
DOI:
10.1002/prot.23200
PubMed ID:
21997831
PubMed Central ID:
PMC4180088
Type:
Article
ISSN:
0887-3585
Sponsors:
Grant sponsor: National Library of Medicine; Grant number: LM07085; Grant sponsor: NIH Institute of General Medical Sciences; Grant number: GM072354; Grant sponsor: KAUST Award; Grant number: KUK-I1-012-43.
Appears in Collections:
Publications Acknowledging KAUST Support

Full metadata record

DC FieldValue Language
dc.contributor.authorMoult, Johnen
dc.contributor.authorFidelis, Krzysztofen
dc.contributor.authorKryshtafovych, Andriyen
dc.contributor.authorTramontano, Annaen
dc.date.accessioned2016-02-25T12:58:30Zen
dc.date.available2016-02-25T12:58:30Zen
dc.date.issued2011en
dc.identifier.citationMoult J, Fidelis K, Kryshtafovych A, Tramontano A (2011) Critical assessment of methods of protein structure prediction (CASP)-round IX. Proteins: Structure, Function, and Bioinformatics 79: 1–5. Available: http://dx.doi.org/10.1002/prot.23200.en
dc.identifier.issn0887-3585en
dc.identifier.pmid21997831en
dc.identifier.doi10.1002/prot.23200en
dc.identifier.urihttp://hdl.handle.net/10754/597895en
dc.description.abstractThis article is an introduction to the special issue of the journal PROTEINS, dedicated to the ninth Critical Assessment of Structure Prediction (CASP) experiment to assess the state of the art in protein structure modeling. The article describes the conduct of the experiment, the categories of prediction included, and outlines the evaluation and assessment procedures. Methods for modeling protein structure continue to advance, although at a more modest pace than in the early CASP experiments. CASP developments of note are indications of improvement in model accuracy for some classes of target, an improved ability to choose the most accurate of a set of generated models, and evidence of improvement in accuracy for short "new fold" models. In addition, a new analysis of regions of models not derivable from the most obvious template structure has revealed better performance than expected.en
dc.description.sponsorshipGrant sponsor: National Library of Medicine; Grant number: LM07085; Grant sponsor: NIH Institute of General Medical Sciences; Grant number: GM072354; Grant sponsor: KAUST Award; Grant number: KUK-I1-012-43.en
dc.publisherWiley-Blackwellen
dc.subjectCASPen
dc.subjectCommunity wide experimenten
dc.subjectProtein structure predictionen
dc.subject.meshModels, Molecularen
dc.titleCritical assessment of methods of protein structure prediction (CASP)-round IXen
dc.typeArticleen
dc.identifier.journalProteins: Structure, Function, and Bioinformaticsen
dc.identifier.pmcidPMC4180088en
dc.contributor.institutionInstitute for Bioscience and Biotechnology Research, and Department of Cell Biology and Molecular Genetics, University of Maryland, Rockville, MD 20850, USA. jmoult@umd.eduen
kaust.grant.numberKUK-I1-012-43en

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