Controlled delivery of antiangiogenic drug to human eye tissue using a MEMS device

Handle URI:
http://hdl.handle.net/10754/597860
Title:
Controlled delivery of antiangiogenic drug to human eye tissue using a MEMS device
Authors:
Pirmoradi, Fatemeh Nazly; Ou, Kevin; Jackson, John K.; Letchford, Kevin; Cui, Jing; Wolf, Ki Tae; Graber, Florian; Zhao, Tom; Matsubara, Joanne A.; Burt, Helen; Chiao, Mu; Lin, Liwei
Abstract:
We demonstrate an implantable MEMS drug delivery device to conduct controlled and on-demand, ex vivo drug transport to human eye tissue. Remotely operated drug delivery to human post-mortem eyes was performed via a MEMS device. The developed curved packaging cover conforms to the eyeball thereby preventing the eye tissue from contacting the actuating membrane. By pulsed operation of the device, using an externally applied magnetic field, the drug released from the device accumulates in a cavity adjacent to the tissue. As such, docetaxel (DTX), an antiangiogenic drug, diffuses through the eye tissue, from sclera and choroid to retina. DTX uptake by sclera and choroid were measured to be 1.93±0.66 and 7.24±0.37 μg/g tissue, respectively, after two hours in pulsed operation mode (10s on/off cycles) at 23°C. During this period, a total amount of 192 ng DTX diffused into the exposed tissue. This MEMS device shows great potential for the treatment of ocular posterior segment diseases such as diabetic retinopathy by introducing a novel way of drug administration to the eye. © 2013 IEEE.
Citation:
Pirmoradi FN, Ou K, Jackson JK, Letchford K, Cui J, et al. (2013) Controlled delivery of antiangiogenic drug to human eye tissue using a MEMS device. 2013 IEEE 26th International Conference on Micro Electro Mechanical Systems (MEMS). Available: http://dx.doi.org/10.1109/MEMSYS.2013.6474161.
Publisher:
Institute of Electrical and Electronics Engineers (IEEE)
Journal:
2013 IEEE 26th International Conference on Micro Electro Mechanical Systems (MEMS)
Issue Date:
Jan-2013
DOI:
10.1109/MEMSYS.2013.6474161
Type:
Conference Paper
Sponsors:
This work was funded in part by the CollaborativeHealth Research Projects, Natural Science andEngineering Research Council of Canada, the CanadianInstitutes of Health Research, and an AcademicExcellence Alliance grant awarded by the KAUST Officeof Competitive Research Funds. Mu Chiao is supportedby the Canada Research Chairs Program. Authors wouldlike to thank Mr. Tom Brubaker and Ms. Kye Lee,undergraduate students in the Lin lab, for their assistance.
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Publications Acknowledging KAUST Support

Full metadata record

DC FieldValue Language
dc.contributor.authorPirmoradi, Fatemeh Nazlyen
dc.contributor.authorOu, Kevinen
dc.contributor.authorJackson, John K.en
dc.contributor.authorLetchford, Kevinen
dc.contributor.authorCui, Jingen
dc.contributor.authorWolf, Ki Taeen
dc.contributor.authorGraber, Florianen
dc.contributor.authorZhao, Tomen
dc.contributor.authorMatsubara, Joanne A.en
dc.contributor.authorBurt, Helenen
dc.contributor.authorChiao, Muen
dc.contributor.authorLin, Liweien
dc.date.accessioned2016-02-25T12:57:57Zen
dc.date.available2016-02-25T12:57:57Zen
dc.date.issued2013-01en
dc.identifier.citationPirmoradi FN, Ou K, Jackson JK, Letchford K, Cui J, et al. (2013) Controlled delivery of antiangiogenic drug to human eye tissue using a MEMS device. 2013 IEEE 26th International Conference on Micro Electro Mechanical Systems (MEMS). Available: http://dx.doi.org/10.1109/MEMSYS.2013.6474161.en
dc.identifier.doi10.1109/MEMSYS.2013.6474161en
dc.identifier.urihttp://hdl.handle.net/10754/597860en
dc.description.abstractWe demonstrate an implantable MEMS drug delivery device to conduct controlled and on-demand, ex vivo drug transport to human eye tissue. Remotely operated drug delivery to human post-mortem eyes was performed via a MEMS device. The developed curved packaging cover conforms to the eyeball thereby preventing the eye tissue from contacting the actuating membrane. By pulsed operation of the device, using an externally applied magnetic field, the drug released from the device accumulates in a cavity adjacent to the tissue. As such, docetaxel (DTX), an antiangiogenic drug, diffuses through the eye tissue, from sclera and choroid to retina. DTX uptake by sclera and choroid were measured to be 1.93±0.66 and 7.24±0.37 μg/g tissue, respectively, after two hours in pulsed operation mode (10s on/off cycles) at 23°C. During this period, a total amount of 192 ng DTX diffused into the exposed tissue. This MEMS device shows great potential for the treatment of ocular posterior segment diseases such as diabetic retinopathy by introducing a novel way of drug administration to the eye. © 2013 IEEE.en
dc.description.sponsorshipThis work was funded in part by the CollaborativeHealth Research Projects, Natural Science andEngineering Research Council of Canada, the CanadianInstitutes of Health Research, and an AcademicExcellence Alliance grant awarded by the KAUST Officeof Competitive Research Funds. Mu Chiao is supportedby the Canada Research Chairs Program. Authors wouldlike to thank Mr. Tom Brubaker and Ms. Kye Lee,undergraduate students in the Lin lab, for their assistance.en
dc.publisherInstitute of Electrical and Electronics Engineers (IEEE)en
dc.titleControlled delivery of antiangiogenic drug to human eye tissue using a MEMS deviceen
dc.typeConference Paperen
dc.identifier.journal2013 IEEE 26th International Conference on Micro Electro Mechanical Systems (MEMS)en
dc.contributor.institutionUC Berkeley, Berkeley, United Statesen
dc.contributor.institutionThe University of British Columbia, Vancouver, Canadaen
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