Handle URI:
http://hdl.handle.net/10754/597777
Title:
Circadian clocks, epigenetics, and cancer
Authors:
Masri, Selma; Kinouchi, Kenichiro; Sassone-Corsi, Paolo
Abstract:
The interplay between circadian rhythm and cancer has been suggested for more than a decade based on the observations that shift work and cancer incidence are linked. Accumulating evidence implicates the circadian clock in cancer survival and proliferation pathways. At the molecular level, multiple control mechanisms have been proposed to link circadian transcription and cell-cycle control to tumorigenesis.The circadian gating of the cell cycle and subsequent control of cell proliferation is an area of active investigation. Moreover, the circadian clock is a transcriptional system that is intricately regulated at the epigenetic level. Interestingly, the epigenetic landscape at the level of histone modifications, DNA methylation, and small regulatory RNAs are differentially controlled in cancer cells. This concept raises the possibility that epigenetic control is a common thread linking the clock with cancer, though little scientific evidence is known to date.This review focuses on the link between circadian clock and cancer, and speculates on the possible connections at the epigenetic level that could further link the circadian clock to tumor initiation or progression.
Citation:
Masri S, Kinouchi K, Sassone-Corsi P (2015) Circadian clocks, epigenetics, and cancer. Current Opinion in Oncology 27: 50–56. Available: http://dx.doi.org/10.1097/CCO.0000000000000153.
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Journal:
Current Opinion in Oncology
Issue Date:
Jan-2015
DOI:
10.1097/CCO.0000000000000153
PubMed ID:
25405464
PubMed Central ID:
PMC4732884
Type:
Article
ISSN:
1040-8746
Sponsors:
Work in the Sassone-Corsi laboratory is supported by the National Institute of Health (NIH), INSERM (Institut National de la Sante et la Recherche Medicale, France), KAUST (King Abdullah University of Science and Technology, Saudi Arabia), and Merieux Pharmaceuticals (France). S.M. is supported by the UC Irvine Chao Family Cancer Center and K.K. is supported by a JSPS postdoctoral fellowship.
Appears in Collections:
Publications Acknowledging KAUST Support

Full metadata record

DC FieldValue Language
dc.contributor.authorMasri, Selmaen
dc.contributor.authorKinouchi, Kenichiroen
dc.contributor.authorSassone-Corsi, Paoloen
dc.date.accessioned2016-02-25T12:56:32Zen
dc.date.available2016-02-25T12:56:32Zen
dc.date.issued2015-01en
dc.identifier.citationMasri S, Kinouchi K, Sassone-Corsi P (2015) Circadian clocks, epigenetics, and cancer. Current Opinion in Oncology 27: 50–56. Available: http://dx.doi.org/10.1097/CCO.0000000000000153.en
dc.identifier.issn1040-8746en
dc.identifier.pmid25405464en
dc.identifier.doi10.1097/CCO.0000000000000153en
dc.identifier.urihttp://hdl.handle.net/10754/597777en
dc.description.abstractThe interplay between circadian rhythm and cancer has been suggested for more than a decade based on the observations that shift work and cancer incidence are linked. Accumulating evidence implicates the circadian clock in cancer survival and proliferation pathways. At the molecular level, multiple control mechanisms have been proposed to link circadian transcription and cell-cycle control to tumorigenesis.The circadian gating of the cell cycle and subsequent control of cell proliferation is an area of active investigation. Moreover, the circadian clock is a transcriptional system that is intricately regulated at the epigenetic level. Interestingly, the epigenetic landscape at the level of histone modifications, DNA methylation, and small regulatory RNAs are differentially controlled in cancer cells. This concept raises the possibility that epigenetic control is a common thread linking the clock with cancer, though little scientific evidence is known to date.This review focuses on the link between circadian clock and cancer, and speculates on the possible connections at the epigenetic level that could further link the circadian clock to tumor initiation or progression.en
dc.description.sponsorshipWork in the Sassone-Corsi laboratory is supported by the National Institute of Health (NIH), INSERM (Institut National de la Sante et la Recherche Medicale, France), KAUST (King Abdullah University of Science and Technology, Saudi Arabia), and Merieux Pharmaceuticals (France). S.M. is supported by the UC Irvine Chao Family Cancer Center and K.K. is supported by a JSPS postdoctoral fellowship.en
dc.publisherOvid Technologies (Wolters Kluwer Health)en
dc.subjectCanceren
dc.subjectCell cycleen
dc.subjectCircadian clocken
dc.subjectEpigenomeen
dc.subjectMetabolismen
dc.subject.meshNeoplasmsen
dc.subject.meshEpigenesis, Geneticen
dc.titleCircadian clocks, epigenetics, and canceren
dc.typeArticleen
dc.identifier.journalCurrent Opinion in Oncologyen
dc.identifier.pmcidPMC4732884en
dc.contributor.institutionDepartment of Biological Chemistry, Center for Epigenetics and Metabolism, University of California, Irvine, Irvine, California, USA.en

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