Cellular blebs: pressure-driven, axisymmetric, membrane protrusions

Handle URI:
http://hdl.handle.net/10754/597744
Title:
Cellular blebs: pressure-driven, axisymmetric, membrane protrusions
Authors:
Woolley, Thomas E.; Gaffney, Eamonn A.; Oliver, James M.; Baker, Ruth E.; Waters, Sarah L.; Goriely, Alain
Abstract:
Blebs are cellular protrusions that are used by cells for multiple purposes including locomotion. A mechanical model for the problem of pressure-driven blebs based on force and moment balances of an axisymmetric shell model is proposed. The formation of a bleb is initiated by weakening the shell over a small region, and the deformation of the cellular membrane from the cortex is obtained during inflation. However, simply weakening the shell leads to an area increase of more than 4 %, which is physically unrealistic. Thus, the model is extended to include a reconfiguration process that allows large blebs to form with small increases in area. It is observed that both geometric and biomechanical constraints are important in this process. In particular, it is shown that although blebs are driven by a pressure difference across the cellular membrane, it is not the limiting factor in determining bleb size. © 2013 Springer-Verlag Berlin Heidelberg.
Citation:
Woolley TE, Gaffney EA, Oliver JM, Baker RE, Waters SL, et al. (2013) Cellular blebs: pressure-driven, axisymmetric, membrane protrusions. Biomech Model Mechanobiol 13: 463–476. Available: http://dx.doi.org/10.1007/s10237-013-0509-9.
Publisher:
Springer Nature
Journal:
Biomechanics and Modeling in Mechanobiology
KAUST Grant Number:
KUK-C1-013-04
Issue Date:
16-Jul-2013
DOI:
10.1007/s10237-013-0509-9
PubMed ID:
23857038
Type:
Article
ISSN:
1617-7959; 1617-7940
Sponsors:
This publication is based on work supported by Award No. KUK-C1-013-04, made by King Abdullah University of Science and Technology (KAUST). AG is a Wolfson Royal Society Merit Holder and acknowledges support from a Reintegration Grant under EC Framework VII.
Appears in Collections:
Publications Acknowledging KAUST Support

Full metadata record

DC FieldValue Language
dc.contributor.authorWoolley, Thomas E.en
dc.contributor.authorGaffney, Eamonn A.en
dc.contributor.authorOliver, James M.en
dc.contributor.authorBaker, Ruth E.en
dc.contributor.authorWaters, Sarah L.en
dc.contributor.authorGoriely, Alainen
dc.date.accessioned2016-02-25T12:55:56Zen
dc.date.available2016-02-25T12:55:56Zen
dc.date.issued2013-07-16en
dc.identifier.citationWoolley TE, Gaffney EA, Oliver JM, Baker RE, Waters SL, et al. (2013) Cellular blebs: pressure-driven, axisymmetric, membrane protrusions. Biomech Model Mechanobiol 13: 463–476. Available: http://dx.doi.org/10.1007/s10237-013-0509-9.en
dc.identifier.issn1617-7959en
dc.identifier.issn1617-7940en
dc.identifier.pmid23857038en
dc.identifier.doi10.1007/s10237-013-0509-9en
dc.identifier.urihttp://hdl.handle.net/10754/597744en
dc.description.abstractBlebs are cellular protrusions that are used by cells for multiple purposes including locomotion. A mechanical model for the problem of pressure-driven blebs based on force and moment balances of an axisymmetric shell model is proposed. The formation of a bleb is initiated by weakening the shell over a small region, and the deformation of the cellular membrane from the cortex is obtained during inflation. However, simply weakening the shell leads to an area increase of more than 4 %, which is physically unrealistic. Thus, the model is extended to include a reconfiguration process that allows large blebs to form with small increases in area. It is observed that both geometric and biomechanical constraints are important in this process. In particular, it is shown that although blebs are driven by a pressure difference across the cellular membrane, it is not the limiting factor in determining bleb size. © 2013 Springer-Verlag Berlin Heidelberg.en
dc.description.sponsorshipThis publication is based on work supported by Award No. KUK-C1-013-04, made by King Abdullah University of Science and Technology (KAUST). AG is a Wolfson Royal Society Merit Holder and acknowledges support from a Reintegration Grant under EC Framework VII.en
dc.publisherSpringer Natureen
dc.subjectBleben
dc.subjectCell mechanicsen
dc.subjectForce balanceen
dc.subjectMembrane growthen
dc.subjectShell modelen
dc.titleCellular blebs: pressure-driven, axisymmetric, membrane protrusionsen
dc.typeArticleen
dc.identifier.journalBiomechanics and Modeling in Mechanobiologyen
dc.contributor.institutionUniversity of Oxford, Oxford, United Kingdomen
kaust.grant.numberKUK-C1-013-04en

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