Cardiac cell modelling: Observations from the heart of the cardiac physiome project

Handle URI:
http://hdl.handle.net/10754/597735
Title:
Cardiac cell modelling: Observations from the heart of the cardiac physiome project
Authors:
Fink, Martin; Niederer, Steven A.; Cherry, Elizabeth M.; Fenton, Flavio H.; Koivumäki, Jussi T.; Seemann, Gunnar; Thul, Rüdiger; Zhang, Henggui; Sachse, Frank B.; Beard, Dan; Crampin, Edmund J.; Smith, Nicolas P.
Abstract:
In this manuscript we review the state of cardiac cell modelling in the context of international initiatives such as the IUPS Physiome and Virtual Physiological Human Projects, which aim to integrate computational models across scales and physics. In particular we focus on the relationship between experimental data and model parameterisation across a range of model types and cellular physiological systems. Finally, in the context of parameter identification and model reuse within the Cardiac Physiome, we suggest some future priority areas for this field. © 2010 Elsevier Ltd.
Citation:
Fink M, Niederer SA, Cherry EM, Fenton FH, Koivumäki JT, et al. (2011) Cardiac cell modelling: Observations from the heart of the cardiac physiome project. Progress in Biophysics and Molecular Biology 104: 2–21. Available: http://dx.doi.org/10.1016/j.pbiomolbio.2010.03.002.
Publisher:
Elsevier BV
Journal:
Progress in Biophysics and Molecular Biology
KAUST Grant Number:
KUK-C1-013-04
Issue Date:
Jan-2011
DOI:
10.1016/j.pbiomolbio.2010.03.002
PubMed ID:
20303361
Type:
Article
ISSN:
0079-6107
Sponsors:
This manuscript is the product of discussions at the Cardiac Physiome Program hosted at, and supported by, the Newton Institute Cambridge United Kingdom. NPS would like to acknowledge support from the United Kingdom Engineering and Physical Sciences Research Council (FP/F059361/1), Biotechnology and Biological Sciences Research Council (BB/F01080X/1) and the European Commission (FP7-ICT-2007-224495: euHeart). FBS acknowledges support by the Nora Eccles Treadwell Foundation. This publication is based on work (by EJC) supported in part by Award No KUK-C1-013-04, made by King Abdullah University of Science and Technology (KAUST). The authors also extend thanks to Liz Gresham for her proofreading of the manuscript.
Appears in Collections:
Publications Acknowledging KAUST Support

Full metadata record

DC FieldValue Language
dc.contributor.authorFink, Martinen
dc.contributor.authorNiederer, Steven A.en
dc.contributor.authorCherry, Elizabeth M.en
dc.contributor.authorFenton, Flavio H.en
dc.contributor.authorKoivumäki, Jussi T.en
dc.contributor.authorSeemann, Gunnaren
dc.contributor.authorThul, Rüdigeren
dc.contributor.authorZhang, Hengguien
dc.contributor.authorSachse, Frank B.en
dc.contributor.authorBeard, Danen
dc.contributor.authorCrampin, Edmund J.en
dc.contributor.authorSmith, Nicolas P.en
dc.date.accessioned2016-02-25T12:55:47Zen
dc.date.available2016-02-25T12:55:47Zen
dc.date.issued2011-01en
dc.identifier.citationFink M, Niederer SA, Cherry EM, Fenton FH, Koivumäki JT, et al. (2011) Cardiac cell modelling: Observations from the heart of the cardiac physiome project. Progress in Biophysics and Molecular Biology 104: 2–21. Available: http://dx.doi.org/10.1016/j.pbiomolbio.2010.03.002.en
dc.identifier.issn0079-6107en
dc.identifier.pmid20303361en
dc.identifier.doi10.1016/j.pbiomolbio.2010.03.002en
dc.identifier.urihttp://hdl.handle.net/10754/597735en
dc.description.abstractIn this manuscript we review the state of cardiac cell modelling in the context of international initiatives such as the IUPS Physiome and Virtual Physiological Human Projects, which aim to integrate computational models across scales and physics. In particular we focus on the relationship between experimental data and model parameterisation across a range of model types and cellular physiological systems. Finally, in the context of parameter identification and model reuse within the Cardiac Physiome, we suggest some future priority areas for this field. © 2010 Elsevier Ltd.en
dc.description.sponsorshipThis manuscript is the product of discussions at the Cardiac Physiome Program hosted at, and supported by, the Newton Institute Cambridge United Kingdom. NPS would like to acknowledge support from the United Kingdom Engineering and Physical Sciences Research Council (FP/F059361/1), Biotechnology and Biological Sciences Research Council (BB/F01080X/1) and the European Commission (FP7-ICT-2007-224495: euHeart). FBS acknowledges support by the Nora Eccles Treadwell Foundation. This publication is based on work (by EJC) supported in part by Award No KUK-C1-013-04, made by King Abdullah University of Science and Technology (KAUST). The authors also extend thanks to Liz Gresham for her proofreading of the manuscript.en
dc.publisherElsevier BVen
dc.subjectCardiacen
dc.subjectCellularen
dc.subjectElectrophysiologyen
dc.subjectMathematical modellingen
dc.subjectPhysiomeen
dc.titleCardiac cell modelling: Observations from the heart of the cardiac physiome projecten
dc.typeArticleen
dc.identifier.journalProgress in Biophysics and Molecular Biologyen
dc.contributor.institutionUniversity of Oxford, Oxford, United Kingdomen
dc.contributor.institutionCornell University, Ithaca, United Statesen
dc.contributor.institutionOulun Yliopisto, Oulu, Finlanden
dc.contributor.institutionKarlsruhe Institute of Technology, Karlsruhe, Germanyen
dc.contributor.institutionUniversity of Nottingham, Nottingham, United Kingdomen
dc.contributor.institutionUniversity of Manchester, Manchester, United Kingdomen
dc.contributor.institutionUniversity of Utah, Salt Lake City, United Statesen
dc.contributor.institutionMedical College of Wisconsin, Milwaukee, United Statesen
dc.contributor.institutionUniversity of Auckland, Auckland, New Zealanden
kaust.grant.numberKUK-C1-013-04en

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