Biocidal Activity of Plasma Modified Electrospun Polysulfone Mats Functionalized with Polyethyleneimine-Capped Silver Nanoparticles

Handle URI:
http://hdl.handle.net/10754/597672
Title:
Biocidal Activity of Plasma Modified Electrospun Polysulfone Mats Functionalized with Polyethyleneimine-Capped Silver Nanoparticles
Authors:
Schiffman, Jessica D.; Wang, Yue; Giannelis, Emmanuel P.; Elimelech, Menachem
Abstract:
The incorporation of silver nanoparticles (AgNPs) into polymeric nanofibers has attracted a great deal of attention due to the strong antimicrobial activity that the resulting fibers exhibit. However, bactericidal efficacy of AgNP-coated electrospun fibrous mats has not yet been demonstrated. In this study, polysulfone (PSf) fibers were electrospun and surface-modified using an oxygen plasma treatment, which allowed for facile irreversible deposition of cationically charged polyethyleneimine (PEI)-AgNPs via electrostatic interactions. The PSf-AgNP mats were characterized for relative silver concentration as a function of plasma treatment time using ICP-MS and changes in contact angle. Plasma treatment of 60 s was the shortest time required for maximum loss of bacteria (Escherichia coli) viability. Time-dependent bacterial cytotoxicity studies indicate that the optimized PSf-AgNP mats exhibit a high level of inactivation against both Gram negative bacteria, Escherichia coli, and Gram positive bacteria, Bacillus anthracis and Staphylococcus aureus. © 2011 American Chemical Society.
Citation:
Schiffman JD, Wang Y, Giannelis EP, Elimelech M (2011) Biocidal Activity of Plasma Modified Electrospun Polysulfone Mats Functionalized with Polyethyleneimine-Capped Silver Nanoparticles. Langmuir 27: 13159–13164. Available: http://dx.doi.org/10.1021/la202605z.
Publisher:
American Chemical Society (ACS)
Journal:
Langmuir
KAUST Grant Number:
KUS-C1-018-02
Issue Date:
Nov-2011
DOI:
10.1021/la202605z
PubMed ID:
21928790
Type:
Article
ISSN:
0743-7463; 1520-5827
Sponsors:
This publication was based on work supported by Award No. KUS-C1-018-02, made by King Abdullah University of Science and Technology (KAUST). We acknowledge use of facilities at the Cornell NanoScale Facility, a member of the National Nanotechnology Infrastructure Network, which is supported by the National Science Foundation (Grant ECS-0335765).
Appears in Collections:
Publications Acknowledging KAUST Support

Full metadata record

DC FieldValue Language
dc.contributor.authorSchiffman, Jessica D.en
dc.contributor.authorWang, Yueen
dc.contributor.authorGiannelis, Emmanuel P.en
dc.contributor.authorElimelech, Menachemen
dc.date.accessioned2016-02-25T12:44:08Zen
dc.date.available2016-02-25T12:44:08Zen
dc.date.issued2011-11en
dc.identifier.citationSchiffman JD, Wang Y, Giannelis EP, Elimelech M (2011) Biocidal Activity of Plasma Modified Electrospun Polysulfone Mats Functionalized with Polyethyleneimine-Capped Silver Nanoparticles. Langmuir 27: 13159–13164. Available: http://dx.doi.org/10.1021/la202605z.en
dc.identifier.issn0743-7463en
dc.identifier.issn1520-5827en
dc.identifier.pmid21928790en
dc.identifier.doi10.1021/la202605zen
dc.identifier.urihttp://hdl.handle.net/10754/597672en
dc.description.abstractThe incorporation of silver nanoparticles (AgNPs) into polymeric nanofibers has attracted a great deal of attention due to the strong antimicrobial activity that the resulting fibers exhibit. However, bactericidal efficacy of AgNP-coated electrospun fibrous mats has not yet been demonstrated. In this study, polysulfone (PSf) fibers were electrospun and surface-modified using an oxygen plasma treatment, which allowed for facile irreversible deposition of cationically charged polyethyleneimine (PEI)-AgNPs via electrostatic interactions. The PSf-AgNP mats were characterized for relative silver concentration as a function of plasma treatment time using ICP-MS and changes in contact angle. Plasma treatment of 60 s was the shortest time required for maximum loss of bacteria (Escherichia coli) viability. Time-dependent bacterial cytotoxicity studies indicate that the optimized PSf-AgNP mats exhibit a high level of inactivation against both Gram negative bacteria, Escherichia coli, and Gram positive bacteria, Bacillus anthracis and Staphylococcus aureus. © 2011 American Chemical Society.en
dc.description.sponsorshipThis publication was based on work supported by Award No. KUS-C1-018-02, made by King Abdullah University of Science and Technology (KAUST). We acknowledge use of facilities at the Cornell NanoScale Facility, a member of the National Nanotechnology Infrastructure Network, which is supported by the National Science Foundation (Grant ECS-0335765).en
dc.publisherAmerican Chemical Society (ACS)en
dc.titleBiocidal Activity of Plasma Modified Electrospun Polysulfone Mats Functionalized with Polyethyleneimine-Capped Silver Nanoparticlesen
dc.typeArticleen
dc.identifier.journalLangmuiren
dc.contributor.institutionYale University, New Haven, United Statesen
dc.contributor.institutionCornell University, Ithaca, United Statesen
dc.contributor.institutionUniversity of Massachusetts, Amherst MA, United Statesen
kaust.grant.numberKUS-C1-018-02en

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