Handle URI:
http://hdl.handle.net/10754/597388
Title:
A rapid and convergent synthesis of the integrastatin core
Authors:
Tadross, Pamela M.; Bugga, Pradeep; Stoltz, Brian M.
Abstract:
The tetracyclic core of the integrastatin natural products has been prepared in a convergent and rapid manner. Our strategy relies upon a palladium(ii)-catalyzed oxidative cyclization to form the central [3.3.1]-dioxabicycle of the natural product core. Overall, the core has been completed in only 4 linear steps from known compounds. © 2011 The Royal Society of Chemistry.
Citation:
Tadross PM, Bugga P, Stoltz BM (2011) A rapid and convergent synthesis of the integrastatin core. Org Biomol Chem 9: 5354. Available: http://dx.doi.org/10.1039/c1ob05725a.
Publisher:
Royal Society of Chemistry (RSC)
Journal:
Organic & Biomolecular Chemistry
KAUST Grant Number:
KUS-11-006-02
Issue Date:
2011
DOI:
10.1039/c1ob05725a
PubMed ID:
21681334
Type:
Article
ISSN:
1477-0520; 1477-0539
Sponsors:
This publication is based on work supported by Award No. KUS-11-006-02, made by King Abdullah University of Science and Technology (KAUST). Financial support from Caltech, the Rose Hills Foundation (undergraduate fellowship to P.B.), and the California HIV/AIDS Research Program (graduate fellowship to P.M.T.) is also gratefully acknowledged.
Appears in Collections:
Publications Acknowledging KAUST Support

Full metadata record

DC FieldValue Language
dc.contributor.authorTadross, Pamela M.en
dc.contributor.authorBugga, Pradeepen
dc.contributor.authorStoltz, Brian M.en
dc.date.accessioned2016-02-25T12:32:11Zen
dc.date.available2016-02-25T12:32:11Zen
dc.date.issued2011en
dc.identifier.citationTadross PM, Bugga P, Stoltz BM (2011) A rapid and convergent synthesis of the integrastatin core. Org Biomol Chem 9: 5354. Available: http://dx.doi.org/10.1039/c1ob05725a.en
dc.identifier.issn1477-0520en
dc.identifier.issn1477-0539en
dc.identifier.pmid21681334en
dc.identifier.doi10.1039/c1ob05725aen
dc.identifier.urihttp://hdl.handle.net/10754/597388en
dc.description.abstractThe tetracyclic core of the integrastatin natural products has been prepared in a convergent and rapid manner. Our strategy relies upon a palladium(ii)-catalyzed oxidative cyclization to form the central [3.3.1]-dioxabicycle of the natural product core. Overall, the core has been completed in only 4 linear steps from known compounds. © 2011 The Royal Society of Chemistry.en
dc.description.sponsorshipThis publication is based on work supported by Award No. KUS-11-006-02, made by King Abdullah University of Science and Technology (KAUST). Financial support from Caltech, the Rose Hills Foundation (undergraduate fellowship to P.B.), and the California HIV/AIDS Research Program (graduate fellowship to P.M.T.) is also gratefully acknowledged.en
dc.publisherRoyal Society of Chemistry (RSC)en
dc.titleA rapid and convergent synthesis of the integrastatin coreen
dc.typeArticleen
dc.identifier.journalOrganic & Biomolecular Chemistryen
dc.contributor.institutionCalifornia Institute of Technology, Pasadena, United Statesen
kaust.grant.numberKUS-11-006-02en
All Items in KAUST are protected by copyright, with all rights reserved, unless otherwise indicated.