A Fibrocontractive Mechanochemical Model of Dermal Wound Closure Incorporating Realistic Growth Factor Kinetics

Handle URI:
http://hdl.handle.net/10754/597267
Title:
A Fibrocontractive Mechanochemical Model of Dermal Wound Closure Incorporating Realistic Growth Factor Kinetics
Authors:
Murphy, Kelly E.; Hall, Cameron L.; Maini, Philip K.; McCue, Scott W.; McElwain, D. L. Sean
Abstract:
Fibroblasts and their activated phenotype, myofibroblasts, are the primary cell types involved in the contraction associated with dermal wound healing. Recent experimental evidence indicates that the transformation from fibroblasts to myofibroblasts involves two distinct processes: The cells are stimulated to change phenotype by the combined actions of transforming growth factor β (TGFβ) and mechanical tension. This observation indicates a need for a detailed exploration of the effect of the strong interactions between the mechanical changes and growth factors in dermal wound healing. We review the experimental findings in detail and develop a model of dermal wound healing that incorporates these phenomena. Our model includes the interactions between TGFβ and collagenase, providing a more biologically realistic form for the growth factor kinetics than those included in previous mechanochemical descriptions. A comparison is made between the model predictions and experimental data on human dermal wound healing and all the essential features are well matched. © 2012 Society for Mathematical Biology.
Citation:
Murphy KE, Hall CL, Maini PK, McCue SW, McElwain DLS (2012) A Fibrocontractive Mechanochemical Model of Dermal Wound Closure Incorporating Realistic Growth Factor Kinetics. Bull Math Biol 74: 1143–1170. Available: http://dx.doi.org/10.1007/s11538-011-9712-y.
Publisher:
Springer Nature
Journal:
Bulletin of Mathematical Biology
KAUST Grant Number:
KUK-C1-013-04
Issue Date:
13-Jan-2012
DOI:
10.1007/s11538-011-9712-y
PubMed ID:
22246694
Type:
Article
ISSN:
0092-8240; 1522-9602
Sponsors:
This research is primarily supported under the Australian Research Council's Discovery Projects funding scheme (project number DP0878011), the Institute of Health and Biomedical Innovation at Queensland University of Technology, and by the Centre for Mathematical Biology, Mathematical Institute at the University of Oxford. PKM was partially supported by a Queensland University of Technology Adjunct Professorship and a Royal Society Wolfson Research Merit Award. This publication was based on work supported in part by Award No. KUK-C1-013-04, made by King Abdullah University of Science and Technology (KAUST).
Appears in Collections:
Publications Acknowledging KAUST Support

Full metadata record

DC FieldValue Language
dc.contributor.authorMurphy, Kelly E.en
dc.contributor.authorHall, Cameron L.en
dc.contributor.authorMaini, Philip K.en
dc.contributor.authorMcCue, Scott W.en
dc.contributor.authorMcElwain, D. L. Seanen
dc.date.accessioned2016-02-25T12:29:25Zen
dc.date.available2016-02-25T12:29:25Zen
dc.date.issued2012-01-13en
dc.identifier.citationMurphy KE, Hall CL, Maini PK, McCue SW, McElwain DLS (2012) A Fibrocontractive Mechanochemical Model of Dermal Wound Closure Incorporating Realistic Growth Factor Kinetics. Bull Math Biol 74: 1143–1170. Available: http://dx.doi.org/10.1007/s11538-011-9712-y.en
dc.identifier.issn0092-8240en
dc.identifier.issn1522-9602en
dc.identifier.pmid22246694en
dc.identifier.doi10.1007/s11538-011-9712-yen
dc.identifier.urihttp://hdl.handle.net/10754/597267en
dc.description.abstractFibroblasts and their activated phenotype, myofibroblasts, are the primary cell types involved in the contraction associated with dermal wound healing. Recent experimental evidence indicates that the transformation from fibroblasts to myofibroblasts involves two distinct processes: The cells are stimulated to change phenotype by the combined actions of transforming growth factor β (TGFβ) and mechanical tension. This observation indicates a need for a detailed exploration of the effect of the strong interactions between the mechanical changes and growth factors in dermal wound healing. We review the experimental findings in detail and develop a model of dermal wound healing that incorporates these phenomena. Our model includes the interactions between TGFβ and collagenase, providing a more biologically realistic form for the growth factor kinetics than those included in previous mechanochemical descriptions. A comparison is made between the model predictions and experimental data on human dermal wound healing and all the essential features are well matched. © 2012 Society for Mathematical Biology.en
dc.description.sponsorshipThis research is primarily supported under the Australian Research Council's Discovery Projects funding scheme (project number DP0878011), the Institute of Health and Biomedical Innovation at Queensland University of Technology, and by the Centre for Mathematical Biology, Mathematical Institute at the University of Oxford. PKM was partially supported by a Queensland University of Technology Adjunct Professorship and a Royal Society Wolfson Research Merit Award. This publication was based on work supported in part by Award No. KUK-C1-013-04, made by King Abdullah University of Science and Technology (KAUST).en
dc.publisherSpringer Natureen
dc.subjectBiomechanicsen
dc.subjectContractionen
dc.subjectMyofibroblastsen
dc.subjectTransforming growth factor-βen
dc.titleA Fibrocontractive Mechanochemical Model of Dermal Wound Closure Incorporating Realistic Growth Factor Kineticsen
dc.typeArticleen
dc.identifier.journalBulletin of Mathematical Biologyen
dc.contributor.institutionQueensland University of Technology QUT, Brisbane, Australiaen
dc.contributor.institutionUniversity of Oxford, Oxford, United Kingdomen
kaust.grant.numberKUK-C1-013-04en
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