Stereotyped patterns of B-cell receptor in splenic marginal zone lymphoma

Handle URI:
http://hdl.handle.net/10754/597017
Title:
Stereotyped patterns of B-cell receptor in splenic marginal zone lymphoma
Authors:
Zibellini, S.; Capello, D.; Forconi, F.; Marcatili, P.; Rossi, D.; Rattotti, S.; Franceschetti, S.; Sozzi, E.; Cencini, E.; Marasca, R.; Baldini, L.; Tucci, A.; Bertoni, F.; Passamonti, F.; Orlandi, E.; Varettoni, M.; Merli, M.; Rizzi, S.; Gattei, V.; Tramontano, A.; Paulli, M.; Gaidano, G.; Arcaini, L.
Abstract:
Antigen stimulation may be important for splenic marginal zone lymphoma pathogenesis. To address this hypothesis, the occurrence of stereotyped B-cell receptors was investigated in 133 SMZL (26 HCV+) compared with 4,414 HCDR3 sequences from public databases. Sixteen SMZL (12%) showed stereotyped BCR; 7 of 86 (8%) SMZL sequences retrieved from public databases also belonged to stereotyped HCDR3 subsets. Three categories of subsets were identified: i) SMZL-specific subsets (n=5), composed only of 12 SMZL (9 HCV- from our series); ii) Non-Hodgkin's lymphoma-like subsets (n=5), comprising 5 SMZL (4 from our series) clustering with other indolent lymphomas; iii) "CLL-like subsets" (n=6), comprising 6 SMZL (3 from our series) that belonged to known CLL subsets (n=4) or clustered with public CLL sequences. Immunoglobulin 3D modeling of 3 subsets revealed similarities in antigen binding regions not limited to HCDR3. Overall, data suggest that the pathogenesis of splenic marginal zone lymphoma may involve also HCV unrelated epitopes or an antigenic trigger common to other indolent lymphomas. ©2010 Ferrata Storti Foundation.
Citation:
Zibellini S, Capello D, Forconi F, Marcatili P, Rossi D, et al. (2010) Stereotyped patterns of B-cell receptor in splenic marginal zone lymphoma. Haematologica 95: 1792–1796. Available: http://dx.doi.org/10.3324/haematol.2010.025437.
Publisher:
Ferrata Storti Foundation (Haematologica)
Journal:
Haematologica
KAUST Grant Number:
KUK-I1-012-43
Issue Date:
29-May-2010
DOI:
10.3324/haematol.2010.025437
PubMed ID:
20511668
PubMed Central ID:
PMC2948108
Type:
Article
ISSN:
0390-6078; 1592-8721
Sponsors:
the authors wish to thank Prof. Andrea Mattevi for helpful discussion. The authors are also grateful to Cristiana Pascutto and Virginia Ferretti for statistical analysis. This publication is based on work partially supported by Ricerca Sanitaria Finalizzata 2008 and 2009, Regione Piemonte, Torino, Italy (to DC, DR and GG); Progetto Integrato Oncologia and Programma di Ricerca di Rilevante Interesse Nazionale (PRIN) 2008, Ministero della Salute, Rome, Italy (to GG); Progetto Giovani Ricercatori 2008 Ministero della Salute, Rome, Italy (to DR); Novara-Associazione Italiana contro le Leucemie, Linfomi e Mielomi (AIL) Onlus, Novara, Italy (to GG, DR); AIL, Venezia Section, Pramaggiore Group, Pramaggiore (VE), Italy (to VG); Associazione Italiana per la Ricerca contro il Cancro, Milan, Italy (to FF, ES, EC and VG); Ministero della Salute (Ricerca Finalizzata IRCCS., “Alleanza Contro il Cancro” and Rete Nazionale Bio-Informatica Oncologica/RN-BIO), Rome, Italy (to VG); Ricerca Scientifica Applicata, Regione Friuli-Venezia-Giulia, Trieste (“Linfonet” Project), Italy (to VG); Award No. KUK-I1-012-43, made by King Abdullah University of Science and Technology (KAUST) (to AT and PM); Oncosuisse grant OCS-02034-02-2007 (to FB); Fondazione per la Ricerca e la Cura sui Linfomi, Lugano, Switzerland (to FB).
Appears in Collections:
Publications Acknowledging KAUST Support

Full metadata record

DC FieldValue Language
dc.contributor.authorZibellini, S.en
dc.contributor.authorCapello, D.en
dc.contributor.authorForconi, F.en
dc.contributor.authorMarcatili, P.en
dc.contributor.authorRossi, D.en
dc.contributor.authorRattotti, S.en
dc.contributor.authorFranceschetti, S.en
dc.contributor.authorSozzi, E.en
dc.contributor.authorCencini, E.en
dc.contributor.authorMarasca, R.en
dc.contributor.authorBaldini, L.en
dc.contributor.authorTucci, A.en
dc.contributor.authorBertoni, F.en
dc.contributor.authorPassamonti, F.en
dc.contributor.authorOrlandi, E.en
dc.contributor.authorVarettoni, M.en
dc.contributor.authorMerli, M.en
dc.contributor.authorRizzi, S.en
dc.contributor.authorGattei, V.en
dc.contributor.authorTramontano, A.en
dc.contributor.authorPaulli, M.en
dc.contributor.authorGaidano, G.en
dc.contributor.authorArcaini, L.en
dc.date.accessioned2016-02-23T13:52:34Zen
dc.date.available2016-02-23T13:52:34Zen
dc.date.issued2010-05-29en
dc.identifier.citationZibellini S, Capello D, Forconi F, Marcatili P, Rossi D, et al. (2010) Stereotyped patterns of B-cell receptor in splenic marginal zone lymphoma. Haematologica 95: 1792–1796. Available: http://dx.doi.org/10.3324/haematol.2010.025437.en
dc.identifier.issn0390-6078en
dc.identifier.issn1592-8721en
dc.identifier.pmid20511668en
dc.identifier.doi10.3324/haematol.2010.025437en
dc.identifier.urihttp://hdl.handle.net/10754/597017en
dc.description.abstractAntigen stimulation may be important for splenic marginal zone lymphoma pathogenesis. To address this hypothesis, the occurrence of stereotyped B-cell receptors was investigated in 133 SMZL (26 HCV+) compared with 4,414 HCDR3 sequences from public databases. Sixteen SMZL (12%) showed stereotyped BCR; 7 of 86 (8%) SMZL sequences retrieved from public databases also belonged to stereotyped HCDR3 subsets. Three categories of subsets were identified: i) SMZL-specific subsets (n=5), composed only of 12 SMZL (9 HCV- from our series); ii) Non-Hodgkin's lymphoma-like subsets (n=5), comprising 5 SMZL (4 from our series) clustering with other indolent lymphomas; iii) "CLL-like subsets" (n=6), comprising 6 SMZL (3 from our series) that belonged to known CLL subsets (n=4) or clustered with public CLL sequences. Immunoglobulin 3D modeling of 3 subsets revealed similarities in antigen binding regions not limited to HCDR3. Overall, data suggest that the pathogenesis of splenic marginal zone lymphoma may involve also HCV unrelated epitopes or an antigenic trigger common to other indolent lymphomas. ©2010 Ferrata Storti Foundation.en
dc.description.sponsorshipthe authors wish to thank Prof. Andrea Mattevi for helpful discussion. The authors are also grateful to Cristiana Pascutto and Virginia Ferretti for statistical analysis. This publication is based on work partially supported by Ricerca Sanitaria Finalizzata 2008 and 2009, Regione Piemonte, Torino, Italy (to DC, DR and GG); Progetto Integrato Oncologia and Programma di Ricerca di Rilevante Interesse Nazionale (PRIN) 2008, Ministero della Salute, Rome, Italy (to GG); Progetto Giovani Ricercatori 2008 Ministero della Salute, Rome, Italy (to DR); Novara-Associazione Italiana contro le Leucemie, Linfomi e Mielomi (AIL) Onlus, Novara, Italy (to GG, DR); AIL, Venezia Section, Pramaggiore Group, Pramaggiore (VE), Italy (to VG); Associazione Italiana per la Ricerca contro il Cancro, Milan, Italy (to FF, ES, EC and VG); Ministero della Salute (Ricerca Finalizzata IRCCS., “Alleanza Contro il Cancro” and Rete Nazionale Bio-Informatica Oncologica/RN-BIO), Rome, Italy (to VG); Ricerca Scientifica Applicata, Regione Friuli-Venezia-Giulia, Trieste (“Linfonet” Project), Italy (to VG); Award No. KUK-I1-012-43, made by King Abdullah University of Science and Technology (KAUST) (to AT and PM); Oncosuisse grant OCS-02034-02-2007 (to FB); Fondazione per la Ricerca e la Cura sui Linfomi, Lugano, Switzerland (to FB).en
dc.publisherFerrata Storti Foundation (Haematologica)en
dc.rightsThis is an open-access paper. Creative Commons Attribution License 3.0en
dc.subjectB cell receptoren
dc.subjectHepatitis c virusen
dc.subjectImmunoglobulin genesen
dc.subjectSplenic marginal zone lymphomaen
dc.titleStereotyped patterns of B-cell receptor in splenic marginal zone lymphomaen
dc.typeArticleen
dc.identifier.journalHaematologicaen
dc.identifier.pmcidPMC2948108en
dc.contributor.institutionUniversita degli Studi di Pavia, Pavia, Italyen
dc.contributor.institutionUniversita degli Studi del Piemonte Orientale Amedeo Avogadro, Novara, Novara, Italyen
dc.contributor.institutionUniversita degli Studi di Siena, Siena, Italyen
dc.contributor.institutionUniversita degli Studi di Roma La Sapienza, Rome, Italyen
dc.contributor.institutionUniversita degli Studi di Modena e Reggio Emilia, Modena, Italyen
dc.contributor.institutionUniversita degli Studi di Milano, Milan, Italyen
dc.contributor.institutionDivision of Hematology, Brescia, Italyen
dc.contributor.institutionOncology Institute of Southern Switzerland, Bellinzona, Switzerlanden
dc.contributor.institutionIRCCS Centro Di Riferimento Oncologico Aviano, Aviano, Italyen
dc.contributor.institutionUniversita degli Studi di Pavia, Pavia, Italyen
kaust.grant.numberKUK-I1-012-43en

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