TiPs: a database of therapeutic targets in pathogens and associated tools.

Handle URI:
http://hdl.handle.net/10754/596827
Title:
TiPs: a database of therapeutic targets in pathogens and associated tools.
Authors:
Lepore, Rosalba; Tramontano, Anna; Via, Allegra
Abstract:
MOTIVATION: The need for new drugs and new targets is particularly compelling in an era that is witnessing an alarming increase of drug resistance in human pathogens. The identification of new targets of known drugs is a promising approach, which has proven successful in several cases. Here, we describe a database that includes information on 5153 putative drug-target pairs for 150 human pathogens derived from available drug-target crystallographic complexes. AVAILABILITY AND IMPLEMENTATION: The TiPs database is freely available at http://biocomputing.it/tips. CONTACT: anna.tramontano@uniroma1.it or allegra.via@uniroma1.it.
Citation:
Lepore R, Tramontano A, Via A (2013) TiPs: a database of therapeutic targets in pathogens and associated tools. Bioinformatics 29: 1821–1822. Available: http://dx.doi.org/10.1093/bioinformatics/btt289.
Publisher:
Oxford University Press (OUP)
Journal:
Bioinformatics
KAUST Grant Number:
KUK-I1-012-43
Issue Date:
21-May-2013
DOI:
10.1093/bioinformatics/btt289
PubMed ID:
23698860
PubMed Central ID:
PMC3702258
Type:
Article
ISSN:
1367-4803; 1460-2059
Sponsors:
Funding: This work was supported by the King Abdullah University of Science and Technology (KAUST), Award No. KUK-I1-012-43, PRIN 20108XYHJS and FIRB RBIN06E9Z8_005.
Appears in Collections:
Publications Acknowledging KAUST Support

Full metadata record

DC FieldValue Language
dc.contributor.authorLepore, Rosalbaen
dc.contributor.authorTramontano, Annaen
dc.contributor.authorVia, Allegraen
dc.date.accessioned2016-02-21T08:51:26Zen
dc.date.available2016-02-21T08:51:26Zen
dc.date.issued2013-05-21en
dc.identifier.citationLepore R, Tramontano A, Via A (2013) TiPs: a database of therapeutic targets in pathogens and associated tools. Bioinformatics 29: 1821–1822. Available: http://dx.doi.org/10.1093/bioinformatics/btt289.en
dc.identifier.issn1367-4803en
dc.identifier.issn1460-2059en
dc.identifier.pmid23698860en
dc.identifier.doi10.1093/bioinformatics/btt289en
dc.identifier.urihttp://hdl.handle.net/10754/596827en
dc.description.abstractMOTIVATION: The need for new drugs and new targets is particularly compelling in an era that is witnessing an alarming increase of drug resistance in human pathogens. The identification of new targets of known drugs is a promising approach, which has proven successful in several cases. Here, we describe a database that includes information on 5153 putative drug-target pairs for 150 human pathogens derived from available drug-target crystallographic complexes. AVAILABILITY AND IMPLEMENTATION: The TiPs database is freely available at http://biocomputing.it/tips. CONTACT: anna.tramontano@uniroma1.it or allegra.via@uniroma1.it.en
dc.description.sponsorshipFunding: This work was supported by the King Abdullah University of Science and Technology (KAUST), Award No. KUK-I1-012-43, PRIN 20108XYHJS and FIRB RBIN06E9Z8_005.en
dc.publisherOxford University Press (OUP)en
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.comen
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/en
dc.subject.meshDrug Discoveryen
dc.subject.meshDatabases, Pharmaceuticalen
dc.titleTiPs: a database of therapeutic targets in pathogens and associated tools.en
dc.typeArticleen
dc.identifier.journalBioinformaticsen
dc.identifier.pmcidPMC3702258en
dc.contributor.institutionDepartment of Physics, Sapienza University, 00185 Rome, Italy.en
kaust.grant.numberKUK-I1-012-43en

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