A database of immunoglobulins with integrated tools: DIGIT.

Handle URI:
http://hdl.handle.net/10754/596755
Title:
A database of immunoglobulins with integrated tools: DIGIT.
Authors:
Chailyan, Anna; Tramontano, Anna; Marcatili, Paolo
Abstract:
The DIGIT (Database of ImmunoGlobulins with Integrated Tools) database (http://biocomputing.it/digit) is an integrated resource storing sequences of annotated immunoglobulin variable domains and enriched with tools for searching and analyzing them. The annotations in the database include information on the type of antigen, the respective germline sequences and on pairing information between light and heavy chains. Other annotations, such as the identification of the complementarity determining regions, assignment of their structural class and identification of mutations with respect to the germline, are computed on the fly and can also be obtained for user-submitted sequences. The system allows customized BLAST searches and automatic building of 3D models of the domains to be performed.
Citation:
Chailyan A, Tramontano A, Marcatili P (2011) A database of immunoglobulins with integrated tools: DIGIT. Nucleic Acids Research 40: D1230–D1234. Available: http://dx.doi.org/10.1093/nar/gkr806.
Publisher:
Oxford University Press (OUP)
Journal:
Nucleic Acids Research
KAUST Grant Number:
KUK-I1-012-43
Issue Date:
10-Nov-2011
DOI:
10.1093/nar/gkr806
PubMed ID:
22080506
PubMed Central ID:
PMC3245095
Type:
Article
ISSN:
0305-1048; 1362-4962
Sponsors:
King Abdullah University of Science and Technology (KAUST) (Award number KUK-I1-012-43); FIRB Proteomica, Ministery of Health grant (Contract No. Onc_Ord 25/07); IIT SEED project. Funding for open access charge: King Abdullah University of Science and Technology (KAUST) (Award number KUK-I1-012-43).
Appears in Collections:
Publications Acknowledging KAUST Support

Full metadata record

DC FieldValue Language
dc.contributor.authorChailyan, Annaen
dc.contributor.authorTramontano, Annaen
dc.contributor.authorMarcatili, Paoloen
dc.date.accessioned2016-02-21T08:49:57Zen
dc.date.available2016-02-21T08:49:57Zen
dc.date.issued2011-11-10en
dc.identifier.citationChailyan A, Tramontano A, Marcatili P (2011) A database of immunoglobulins with integrated tools: DIGIT. Nucleic Acids Research 40: D1230–D1234. Available: http://dx.doi.org/10.1093/nar/gkr806.en
dc.identifier.issn0305-1048en
dc.identifier.issn1362-4962en
dc.identifier.pmid22080506en
dc.identifier.doi10.1093/nar/gkr806en
dc.identifier.urihttp://hdl.handle.net/10754/596755en
dc.description.abstractThe DIGIT (Database of ImmunoGlobulins with Integrated Tools) database (http://biocomputing.it/digit) is an integrated resource storing sequences of annotated immunoglobulin variable domains and enriched with tools for searching and analyzing them. The annotations in the database include information on the type of antigen, the respective germline sequences and on pairing information between light and heavy chains. Other annotations, such as the identification of the complementarity determining regions, assignment of their structural class and identification of mutations with respect to the germline, are computed on the fly and can also be obtained for user-submitted sequences. The system allows customized BLAST searches and automatic building of 3D models of the domains to be performed.en
dc.description.sponsorshipKing Abdullah University of Science and Technology (KAUST) (Award number KUK-I1-012-43); FIRB Proteomica, Ministery of Health grant (Contract No. Onc_Ord 25/07); IIT SEED project. Funding for open access charge: King Abdullah University of Science and Technology (KAUST) (Award number KUK-I1-012-43).en
dc.publisherOxford University Press (OUP)en
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0en
dc.subject.meshDatabases, Proteinen
dc.titleA database of immunoglobulins with integrated tools: DIGIT.en
dc.typeArticleen
dc.identifier.journalNucleic Acids Researchen
dc.identifier.pmcidPMC3245095en
dc.contributor.institutionUniversita degli Studi di Roma La Sapienza, Rome, Italyen
dc.contributor.institutionIstituto Italiano di Tecnologia, Genoa, Italyen
kaust.grant.numberKUK-I1-012-43en

Related articles on PubMed

All Items in KAUST are protected by copyright, with all rights reserved, unless otherwise indicated.