Amplification of Chirality through Self-Replication of Micellar Aggregates in Water

Handle URI:
http://hdl.handle.net/10754/594282
Title:
Amplification of Chirality through Self-Replication of Micellar Aggregates in Water
Authors:
Bukhriakov, Konstantin; Almahdali, Sarah ( 0000-0002-3798-1354 ) ; Rodionov, Valentin
Abstract:
We describe a system in which the self-replication of micellar aggregates results in a spontaneous amplification of chirality in the reaction products. In this system, amphiphiles are synthesized from two "clickable" fragments: a water-soluble "head" and a hydrophobic "tail". Under biphasic conditions, the reaction is autocatalytic, as aggregates facilitate the transfer of hydrophobic molecules to the aqueous phase. When chiral, partially enantioenriched surfactant heads are used, a strong nonlinear induction of chirality in the reaction products is observed. Preseeding the reaction mixture with an amphiphile of one chirality results in the amplification of this product and therefore information transfer between generations of self-replicating aggregates. Because our amphiphiles are capable of catalysis, information transfer, and self-assembly into bounded structures, they present a plausible model for prenucleic acid "lipid world" entities. © 2015 American Chemical Society.
KAUST Department:
KAUST Catalysis Center (KCC); Physical Sciences and Engineering (PSE) Division
Citation:
Bukhryakov KV, Almahdali S, Rodionov VO (2015) Amplification of Chirality through Self-Replication of Micellar Aggregates in Water. Langmuir 31: 2931–2935. Available: http://dx.doi.org/10.1021/la504984j.
Publisher:
American Chemical Society (ACS)
Journal:
Langmuir
Issue Date:
17-Mar-2015
DOI:
10.1021/la504984j
PubMed ID:
25740116
Type:
Article
ISSN:
0743-7463; 1520-5827
Appears in Collections:
Articles; Physical Sciences and Engineering (PSE) Division; KAUST Catalysis Center (KCC)

Full metadata record

DC FieldValue Language
dc.contributor.authorBukhriakov, Konstantinen
dc.contributor.authorAlmahdali, Sarahen
dc.contributor.authorRodionov, Valentinen
dc.date.accessioned2016-01-19T14:45:07Zen
dc.date.available2016-01-19T14:45:07Zen
dc.date.issued2015-03-17en
dc.identifier.citationBukhryakov KV, Almahdali S, Rodionov VO (2015) Amplification of Chirality through Self-Replication of Micellar Aggregates in Water. Langmuir 31: 2931–2935. Available: http://dx.doi.org/10.1021/la504984j.en
dc.identifier.issn0743-7463en
dc.identifier.issn1520-5827en
dc.identifier.pmid25740116en
dc.identifier.doi10.1021/la504984jen
dc.identifier.urihttp://hdl.handle.net/10754/594282en
dc.description.abstractWe describe a system in which the self-replication of micellar aggregates results in a spontaneous amplification of chirality in the reaction products. In this system, amphiphiles are synthesized from two "clickable" fragments: a water-soluble "head" and a hydrophobic "tail". Under biphasic conditions, the reaction is autocatalytic, as aggregates facilitate the transfer of hydrophobic molecules to the aqueous phase. When chiral, partially enantioenriched surfactant heads are used, a strong nonlinear induction of chirality in the reaction products is observed. Preseeding the reaction mixture with an amphiphile of one chirality results in the amplification of this product and therefore information transfer between generations of self-replicating aggregates. Because our amphiphiles are capable of catalysis, information transfer, and self-assembly into bounded structures, they present a plausible model for prenucleic acid "lipid world" entities. © 2015 American Chemical Society.en
dc.publisherAmerican Chemical Society (ACS)en
dc.titleAmplification of Chirality through Self-Replication of Micellar Aggregates in Wateren
dc.typeArticleen
dc.contributor.departmentKAUST Catalysis Center (KCC)en
dc.contributor.departmentPhysical Sciences and Engineering (PSE) Divisionen
dc.identifier.journalLangmuiren
kaust.authorBukhriakov, Konstantinen
kaust.authorAlmahdali, Sarahen
kaust.authorRodionov, Valentinen

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