In vivo evaluation of the biodistribution of intravenously administered naked and functionalised silver nanoparticles in rabbit

Handle URI:
http://hdl.handle.net/10754/594278
Title:
In vivo evaluation of the biodistribution of intravenously administered naked and functionalised silver nanoparticles in rabbit
Authors:
Ashraf, Ayesha; Sharif, Rehana; Ahmad, Munir; Masood, Misbah; Shahid, Abubakar; Anjum, Dalaver H.; Rafique, Muhammad Shahid; Ghani, Sheeba
Abstract:
Water-based suspension of silver nanoparticles (AgNPs) and dextran coated AgNPs (dextran-AgNPs) are fabricated and characterised for intravenous administration. A simple method for radiolabelling of nanoparticles with 99mTc was used. Labelling efficiency for AgNPs and dextran-AgNPs was found to be more than 80 and 88%, respectively. In vivo tissue uptake of nanoparticles during dynamic phase, after systematic administration by biodistribution analysis with single-photon emission computed tomography imaging has been evaluated. Biodistribution analysis revealed that 99mTc-AgNPs and 99mTc-dextran-AgNPs are mainly accumulated in liver/spleen region but 99mTc-dextran-AgNPs delayed recognition and uptake by liver. Results indicate that dextran-AgNPs are able to evade reticuloendothelum system with enhanced blood retention time. Accumulation of nanoparticles in liver/spleen region implicates the utilisation of AgNPs for liver cancer treatment. © 2015 The Institution of Engineering and Technology.
KAUST Department:
Advanced Nanofabrication and Thin Film Core Lab; Imaging and Characterization Core Lab
Citation:
OCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd"><html> <head> <title>Current Links for doi: 10.1049/iet-nbt.2014.0075</title> <meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><link rel="stylesheet" rev="stylesheet" type="text/css" href="/docs/iPage/css/iet_body.css"> </head> <body bgcolor="#FFFFFF"> <table width="57%"> <tr> <td><a href="http://www.theiet.org"><img src="/docs/iPage/images/iet.gif" alt="Institution of Engineering and Technology" border="0" align="left"></a></td></tr> <tr> <td><br/></td> </tr> <tr> <td>The IET is a world leading professional organisation sharing and advancing knowledge to promote science, engineering and technology across the world. <br> <hr> </td> </tr> </table> <table width="57%"> <tr> <td><tr><td><b>In vivo evaluation of the biodistribution of intravenously administered naked and functionalised silver nanoparticles in rabbit</b></td></tr><tr><td>Ashraf,Ayesha et al.</td></tr><tr><td><i>IET Nanobiotechnology</i>(2015),9(6):368</td></tr><tr><td><a href='http://dx.doi.org/10.1049/iet-nbt.2014.0075'>http://dx.doi.org/10.1049/iet-nbt.2014.0075</td></tr></td> <tr> <tr><td><hr></td></tr> </table> <table width="57%"> <tr> <td colspan="2"> This article is available from multiple sources. <b>Please click on the logo</b> of the service to which you have a subscription, or click any logo to obtain pay-per-view access.<br><br></td> </tr> <tr> <td width="35%"><a href="http://digital-library.theiet.org/content/journals/10.1049/iet-nbt.2014.0075"><img src="/docs/iPage/images/idl.gif" border="0" alt="IET Digital Library on Scitation"></a></td> <td width="65%"><br>&nbsp;&nbsp;Access the IET Digital Library<br><br></td> </tr> <tr> <td><br/><br/></td> </tr> <tr> <td><a href="http://ieeexplore.ieee.org/lpdocs/epic03/wrapper.htm?arnumber=7350376"><img src="/docs/iPage/images/iel.gif" border="0" alt="IEL on IEEE Xplore"></a></td> <td><br>&nbsp;&nbsp;Access the IEL (IEEE/IET Electronic Library) on IEEE Xplore&#174;</a><br><br></td></td> </tr> </table> </body></html>
Publisher:
Institution of Engineering and Technology (IET)
Journal:
IET Nanobiotechnology
Issue Date:
1-Dec-2015
DOI:
10.1049/iet-nbt.2014.0075
PubMed ID:
26647813
Type:
Article
ISSN:
1751-8741; 1751-875X
Appears in Collections:
Articles; Advanced Nanofabrication, Imaging and Characterization Core Lab

Full metadata record

DC FieldValue Language
dc.contributor.authorAshraf, Ayeshaen
dc.contributor.authorSharif, Rehanaen
dc.contributor.authorAhmad, Muniren
dc.contributor.authorMasood, Misbahen
dc.contributor.authorShahid, Abubakaren
dc.contributor.authorAnjum, Dalaver H.en
dc.contributor.authorRafique, Muhammad Shahiden
dc.contributor.authorGhani, Sheebaen
dc.date.accessioned2016-01-19T14:45:02Zen
dc.date.available2016-01-19T14:45:02Zen
dc.date.issued2015-12-01en
dc.identifier.citationOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd"><html> <head> <title>Current Links for doi: 10.1049/iet-nbt.2014.0075</title> <meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><link rel="stylesheet" rev="stylesheet" type="text/css" href="/docs/iPage/css/iet_body.css"> </head> <body bgcolor="#FFFFFF"> <table width="57%"> <tr> <td><a href="http://www.theiet.org"><img src="/docs/iPage/images/iet.gif" alt="Institution of Engineering and Technology" border="0" align="left"></a></td></tr> <tr> <td><br/></td> </tr> <tr> <td>The IET is a world leading professional organisation sharing and advancing knowledge to promote science, engineering and technology across the world. <br> <hr> </td> </tr> </table> <table width="57%"> <tr> <td><tr><td><b>In vivo evaluation of the biodistribution of intravenously administered naked and functionalised silver nanoparticles in rabbit</b></td></tr><tr><td>Ashraf,Ayesha et al.</td></tr><tr><td><i>IET Nanobiotechnology</i>(2015),9(6):368</td></tr><tr><td><a href='http://dx.doi.org/10.1049/iet-nbt.2014.0075'>http://dx.doi.org/10.1049/iet-nbt.2014.0075</td></tr></td> <tr> <tr><td><hr></td></tr> </table> <table width="57%"> <tr> <td colspan="2"> This article is available from multiple sources. <b>Please click on the logo</b> of the service to which you have a subscription, or click any logo to obtain pay-per-view access.<br><br></td> </tr> <tr> <td width="35%"><a href="http://digital-library.theiet.org/content/journals/10.1049/iet-nbt.2014.0075"><img src="/docs/iPage/images/idl.gif" border="0" alt="IET Digital Library on Scitation"></a></td> <td width="65%"><br>&nbsp;&nbsp;Access the IET Digital Library<br><br></td> </tr> <tr> <td><br/><br/></td> </tr> <tr> <td><a href="http://ieeexplore.ieee.org/lpdocs/epic03/wrapper.htm?arnumber=7350376"><img src="/docs/iPage/images/iel.gif" border="0" alt="IEL on IEEE Xplore"></a></td> <td><br>&nbsp;&nbsp;Access the IEL (IEEE/IET Electronic Library) on IEEE Xplore&#174;</a><br><br></td></td> </tr> </table> </body></html>en
dc.identifier.issn1751-8741en
dc.identifier.issn1751-875Xen
dc.identifier.pmid26647813en
dc.identifier.doi10.1049/iet-nbt.2014.0075en
dc.identifier.urihttp://hdl.handle.net/10754/594278en
dc.description.abstractWater-based suspension of silver nanoparticles (AgNPs) and dextran coated AgNPs (dextran-AgNPs) are fabricated and characterised for intravenous administration. A simple method for radiolabelling of nanoparticles with 99mTc was used. Labelling efficiency for AgNPs and dextran-AgNPs was found to be more than 80 and 88%, respectively. In vivo tissue uptake of nanoparticles during dynamic phase, after systematic administration by biodistribution analysis with single-photon emission computed tomography imaging has been evaluated. Biodistribution analysis revealed that 99mTc-AgNPs and 99mTc-dextran-AgNPs are mainly accumulated in liver/spleen region but 99mTc-dextran-AgNPs delayed recognition and uptake by liver. Results indicate that dextran-AgNPs are able to evade reticuloendothelum system with enhanced blood retention time. Accumulation of nanoparticles in liver/spleen region implicates the utilisation of AgNPs for liver cancer treatment. © 2015 The Institution of Engineering and Technology.en
dc.publisherInstitution of Engineering and Technology (IET)en
dc.titleIn vivo evaluation of the biodistribution of intravenously administered naked and functionalised silver nanoparticles in rabbiten
dc.typeArticleen
dc.contributor.departmentAdvanced Nanofabrication and Thin Film Core Laben
dc.contributor.departmentImaging and Characterization Core Laben
dc.identifier.journalIET Nanobiotechnologyen
dc.contributor.institutionPhysics Department, University of Engineering and Technology, Lahore, Pakistanen
dc.contributor.institutionInstitute of Nuclear Medicine and Oncology (INMOL), Lahore, Pakistanen
kaust.authorAnjum, Dalaver H.en

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