A cyclically actuated electrolytic drug delivery device

Handle URI:
http://hdl.handle.net/10754/594268
Title:
A cyclically actuated electrolytic drug delivery device
Authors:
Yi, Ying; Buttner, Ulrich; Foulds, Ian G.
Abstract:
This work, focusing on an implantable drug delivery system, presents the first prototype electrolytic pump that combines a catalytic reformer and a cyclically actuated mode. These features improve the release performance and extend the lifetime of the device. Using our platinum (Pt)-coated carbon fiber mesh that acts as a catalytic reforming element, the cyclical mode is improved because the faster recombination rate allows for a shorter cycling time for drug delivery. Another feature of our device is that it uses a solid-drug-in-reservoir (SDR) approach, which allows small amounts of a solid drug to be dissolved in human fluid, forming a reproducible drug solution for long-term therapies. We have conducted proof-of-principle drug delivery studies using such an electrolytic pump and solvent blue 38 as the drug substitute. These tests demonstrate power-controlled and pulsatile release profiles of the chemical substance, as well as the feasibility of this device. A drug delivery rate of 11.44 ± 0.56 μg min-1 was achieved by using an input power of 4 mW for multiple pulses, which indicates the stability of our system. © The Royal Society of Chemistry 2015.
KAUST Department:
Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
Citation:
Yi Y, Buttner U, Foulds IG (2015) A cyclically actuated electrolytic drug delivery device. Lab Chip 15: 3540–3548. Available: http://dx.doi.org/10.1039/c5lc00703h.
Publisher:
Royal Society of Chemistry (RSC)
Journal:
Lab Chip
Issue Date:
2015
DOI:
10.1039/c5lc00703h
PubMed ID:
26198777
Type:
Article
ISSN:
1473-0197; 1473-0189
Appears in Collections:
Articles; Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorYi, Yingen
dc.contributor.authorButtner, Ulrichen
dc.contributor.authorFoulds, Ian G.en
dc.date.accessioned2016-01-19T14:44:47Zen
dc.date.available2016-01-19T14:44:47Zen
dc.date.issued2015en
dc.identifier.citationYi Y, Buttner U, Foulds IG (2015) A cyclically actuated electrolytic drug delivery device. Lab Chip 15: 3540–3548. Available: http://dx.doi.org/10.1039/c5lc00703h.en
dc.identifier.issn1473-0197en
dc.identifier.issn1473-0189en
dc.identifier.pmid26198777en
dc.identifier.doi10.1039/c5lc00703hen
dc.identifier.urihttp://hdl.handle.net/10754/594268en
dc.description.abstractThis work, focusing on an implantable drug delivery system, presents the first prototype electrolytic pump that combines a catalytic reformer and a cyclically actuated mode. These features improve the release performance and extend the lifetime of the device. Using our platinum (Pt)-coated carbon fiber mesh that acts as a catalytic reforming element, the cyclical mode is improved because the faster recombination rate allows for a shorter cycling time for drug delivery. Another feature of our device is that it uses a solid-drug-in-reservoir (SDR) approach, which allows small amounts of a solid drug to be dissolved in human fluid, forming a reproducible drug solution for long-term therapies. We have conducted proof-of-principle drug delivery studies using such an electrolytic pump and solvent blue 38 as the drug substitute. These tests demonstrate power-controlled and pulsatile release profiles of the chemical substance, as well as the feasibility of this device. A drug delivery rate of 11.44 ± 0.56 μg min-1 was achieved by using an input power of 4 mW for multiple pulses, which indicates the stability of our system. © The Royal Society of Chemistry 2015.en
dc.publisherRoyal Society of Chemistry (RSC)en
dc.titleA cyclically actuated electrolytic drug delivery deviceen
dc.typeArticleen
dc.contributor.departmentComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Divisionen
dc.identifier.journalLab Chipen
dc.contributor.institutionSchool of Engineering, University of British Columbia, Kelowna, BC, Canadaen
kaust.authorButtner, Ulrichen
kaust.authorFoulds, Ian G.en

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