Microwave-Induced Chemotoxicity of Polydopamine-Coated Magnetic Nanocubes

Handle URI:
http://hdl.handle.net/10754/594191
Title:
Microwave-Induced Chemotoxicity of Polydopamine-Coated Magnetic Nanocubes
Authors:
Julfakyan, Khachatur ( 0000-0003-2482-0911 ) ; Fatieiev, Yevhen ( 0000-0002-2844-8427 ) ; Alsaiari, Shahad K.; Deng, Lin ( 0000-0001-8954-5610 ) ; Ezzeddine, Alaa; Zhang, Dingyuan; Rotello, Vincent M.; Khashab, Niveen M. ( 0000-0003-2728-0666 )
Abstract:
Polydopamine-coated FeCo nanocubes (PDFCs) were successfully synthesized and tested under microwave irradiation of 2.45 GHz frequency and 0.86 W/cm2 power. These particles were found to be non-toxic in the absence of irradiation, but gained significant toxicity upon irradiation. Interestingly, no increase in relative heating rate was observed when the PDFCs were irradiated in solution, eliminating nanoparticle (NP)-induced thermal ablation as the source of toxicity. Based on these studies, we propose that microwave-induced redox processes generate the observed toxicity. © 2015 by the authors; licensee MDPI, Basel, Switzerland.
KAUST Department:
Advanced Membranes and Porous Materials Research Center; Smart Hybrid Materials (SHMs) lab
Citation:
Julfakyan K, Fatieiev Y, Alsaiari S, Deng L, Ezzeddine A, et al. (2015) Microwave-Induced Chemotoxicity of Polydopamine-Coated Magnetic Nanocubes. International Journal of Molecular Sciences 16: 18283–18292. Available: http://dx.doi.org/10.3390/ijms160818283.
Publisher:
MDPI AG
Journal:
International Journal of Molecular Sciences
Issue Date:
6-Aug-2015
DOI:
10.3390/ijms160818283
PubMed ID:
26287162
PubMed Central ID:
PMC4581245
Type:
Article
ISSN:
1422-0067
Appears in Collections:
Articles; Advanced Membranes and Porous Materials Research Center; Controlled Release and Delivery Laboratory

Full metadata record

DC FieldValue Language
dc.contributor.authorJulfakyan, Khachaturen
dc.contributor.authorFatieiev, Yevhenen
dc.contributor.authorAlsaiari, Shahad K.en
dc.contributor.authorDeng, Linen
dc.contributor.authorEzzeddine, Alaaen
dc.contributor.authorZhang, Dingyuanen
dc.contributor.authorRotello, Vincent M.en
dc.contributor.authorKhashab, Niveen M.en
dc.date.accessioned2016-01-19T13:23:31Zen
dc.date.available2016-01-19T13:23:31Zen
dc.date.issued2015-08-06en
dc.identifier.citationJulfakyan K, Fatieiev Y, Alsaiari S, Deng L, Ezzeddine A, et al. (2015) Microwave-Induced Chemotoxicity of Polydopamine-Coated Magnetic Nanocubes. International Journal of Molecular Sciences 16: 18283–18292. Available: http://dx.doi.org/10.3390/ijms160818283.en
dc.identifier.issn1422-0067en
dc.identifier.pmid26287162en
dc.identifier.doi10.3390/ijms160818283en
dc.identifier.urihttp://hdl.handle.net/10754/594191en
dc.description.abstractPolydopamine-coated FeCo nanocubes (PDFCs) were successfully synthesized and tested under microwave irradiation of 2.45 GHz frequency and 0.86 W/cm2 power. These particles were found to be non-toxic in the absence of irradiation, but gained significant toxicity upon irradiation. Interestingly, no increase in relative heating rate was observed when the PDFCs were irradiated in solution, eliminating nanoparticle (NP)-induced thermal ablation as the source of toxicity. Based on these studies, we propose that microwave-induced redox processes generate the observed toxicity. © 2015 by the authors; licensee MDPI, Basel, Switzerland.en
dc.publisherMDPI AGen
dc.subjectFeCo nanocubesen
dc.subjectMicrowave radiationen
dc.subjectNanomedicineen
dc.subjectPolydopamineen
dc.titleMicrowave-Induced Chemotoxicity of Polydopamine-Coated Magnetic Nanocubesen
dc.typeArticleen
dc.contributor.departmentAdvanced Membranes and Porous Materials Research Centeren
dc.contributor.departmentSmart Hybrid Materials (SHMs) laben
dc.identifier.journalInternational Journal of Molecular Sciencesen
dc.identifier.pmcidPMC4581245en
dc.contributor.institutionKey Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional Molecules, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, Chinaen
dc.contributor.institutionDepartment of Chemistry, University of Massachusetts Amherst, Amherst, MA, United Statesen
kaust.authorJulfakyan, Khachaturen
kaust.authorFatieiev, Yevhenen
kaust.authorAlsaiari, Shahad K.en
kaust.authorDeng, Linen
kaust.authorEzzeddine, Alaaen
kaust.authorZhang, Dingyuanen
kaust.authorKhashab, Niveen M.en

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