TH17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26

Handle URI:
http://hdl.handle.net/10754/594165
Title:
TH17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26
Authors:
Meller, Stephan; Di Domizio, Jeremy; Voo, Kui S; Friedrich, Heike C; Chamilos, Georgios; Ganguly, Dipyaman; Conrad, Curdin; Gregorio, Josh; Le Roy, Didier; Roger, Thierry ( 0000-0002-9358-0109 ) ; Ladbury, John E; Homey, Bernhard; Watowich, Stanley; Modlin, Robert L; Kontoyiannis, Dimitrios P; Liu, Yong-Jun; Arold, Stefan T. ( 0000-0001-5278-0668 ) ; Gilliet, Michel
Abstract:
Interleukin 17-producing helper T cells (TH 17 cells) have a major role in protection against infections and in mediating autoimmune diseases, yet the mechanisms involved are incompletely understood. We found that interleukin 26 (IL-26), a human TH17 cell-derived cytokine, is a cationic amphipathic protein that kills extracellular bacteria via membrane-pore formation. Furthermore, TH17 cell-derived IL-26 formed complexes with bacterial DNA and self-DNA released by dying bacteria and host cells. The resulting IL-26-DNA complexes triggered the production of type I interferon by plasmacytoid dendritic cells via activation of Toll-like receptor 9, but independently of the IL-26 receptor. These findings provide insights into the potent antimicrobial and proinflammatory function of TH17 cells by showing that IL-26 is a natural human antimicrobial that promotes immune sensing of bacterial and host cell death. © 2015 Nature America, Inc.
KAUST Department:
Biological and Environmental Sciences and Engineering (BESE) Division
Citation:
Meller S, Di Domizio J, Voo KS, Friedrich HC, Chamilos G, et al. (2015) TH17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26. Nat Immunol 16: 970–979. Available: http://dx.doi.org/10.1038/ni.3211.
Publisher:
Nature Publishing Group
Journal:
Nature Immunology
Issue Date:
13-Jul-2015
DOI:
10.1038/ni.3211
PubMed ID:
26168081
Type:
Article
ISSN:
1529-2908; 1529-2916
Appears in Collections:
Articles; Biological and Environmental Sciences and Engineering (BESE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorMeller, Stephanen
dc.contributor.authorDi Domizio, Jeremyen
dc.contributor.authorVoo, Kui Sen
dc.contributor.authorFriedrich, Heike Cen
dc.contributor.authorChamilos, Georgiosen
dc.contributor.authorGanguly, Dipyamanen
dc.contributor.authorConrad, Curdinen
dc.contributor.authorGregorio, Joshen
dc.contributor.authorLe Roy, Didieren
dc.contributor.authorRoger, Thierryen
dc.contributor.authorLadbury, John Een
dc.contributor.authorHomey, Bernharden
dc.contributor.authorWatowich, Stanleyen
dc.contributor.authorModlin, Robert Len
dc.contributor.authorKontoyiannis, Dimitrios Pen
dc.contributor.authorLiu, Yong-Junen
dc.contributor.authorArold, Stefan T.en
dc.contributor.authorGilliet, Michelen
dc.date.accessioned2016-01-19T13:23:01Zen
dc.date.available2016-01-19T13:23:01Zen
dc.date.issued2015-07-13en
dc.identifier.citationMeller S, Di Domizio J, Voo KS, Friedrich HC, Chamilos G, et al. (2015) TH17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26. Nat Immunol 16: 970–979. Available: http://dx.doi.org/10.1038/ni.3211.en
dc.identifier.issn1529-2908en
dc.identifier.issn1529-2916en
dc.identifier.pmid26168081en
dc.identifier.doi10.1038/ni.3211en
dc.identifier.urihttp://hdl.handle.net/10754/594165en
dc.description.abstractInterleukin 17-producing helper T cells (TH 17 cells) have a major role in protection against infections and in mediating autoimmune diseases, yet the mechanisms involved are incompletely understood. We found that interleukin 26 (IL-26), a human TH17 cell-derived cytokine, is a cationic amphipathic protein that kills extracellular bacteria via membrane-pore formation. Furthermore, TH17 cell-derived IL-26 formed complexes with bacterial DNA and self-DNA released by dying bacteria and host cells. The resulting IL-26-DNA complexes triggered the production of type I interferon by plasmacytoid dendritic cells via activation of Toll-like receptor 9, but independently of the IL-26 receptor. These findings provide insights into the potent antimicrobial and proinflammatory function of TH17 cells by showing that IL-26 is a natural human antimicrobial that promotes immune sensing of bacterial and host cell death. © 2015 Nature America, Inc.en
dc.publisherNature Publishing Groupen
dc.titleTH17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26en
dc.typeArticleen
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Divisionen
dc.identifier.journalNature Immunologyen
dc.contributor.institutionDepartment of Immunology, University of Texas, MD Anderson Cancer Center, Houston, TX, United Statesen
dc.contributor.institutionDepartment of Dermatology, Heinrich-Heine-University, Medical Faculty, Düsseldorf, Germanyen
dc.contributor.institutionDepartment of Dermatology, University Hospital CHUV, Lausanne, Switzerlanden
dc.contributor.institutionDepartment of Infectious Diseases, University of Texas, MD Anderson Cancer Center, Houston, TX, United Statesen
dc.contributor.institutionDepartment of Infectious Diseases, University Hospital CHUV, Lausanne, Switzerlanden
dc.contributor.institutionSchool of Molecular and Cell Biology, University of Leeds, Leeds, United Kingdomen
dc.contributor.institutionDepartment of Biochemistry and Molecular Biology, University of Texas, Medical Branch, Galveston, TX, United Statesen
dc.contributor.institutionDivision of Dermatology, David Geffen School of Medicine, Los Angeles, CA, United Statesen
dc.contributor.institutionDepartment of Respiratory, Inflammation and Autoimmunity, MedImmune, Gaithersburg, MD, United Statesen
kaust.authorArold, Stefan T.en

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