Genomic evidence for the Pleistocene and recent population history of Native Americans

Handle URI:
http://hdl.handle.net/10754/594129
Title:
Genomic evidence for the Pleistocene and recent population history of Native Americans
Authors:
Raghavan, Maanasa; Steinrücken, Matthias; Harris, Kelley; Schiffels, Stephan; Rasmussen, Simon; DeGiorgio, Michael; Albrechtsen, Anders; Valdiosera, Cristina; Ávila-Arcos, María C.; Malaspinas, Anna Sapfo; Eriksson, Anders ( 0000-0003-3436-3726 ) ; Moltke, Ida; Metspalu, Mait; Homburger, Julian R.; Wall, Jeff; Cornejo, Omar E.; Moreno-Mayar, J. Víctor; Korneliussen, Thorfinn S.; Pierre, Tracey; Rasmussen, Morten; Campos, Paula F.; De Barros Damgaard, Peter; Allentoft, Morten E.; Lindo, John; Metspalu, Ene; Rodríguez-Varela, Ricardo; Mansilla, Josefina; Henrickson, Celeste; Seguin-Orlando, Andaine; Malmstöm, Helena; Stafford, Thomas; Shringarpure, Suyash S.; Moreno-Estrada, Andrés; Karmin, Monika; Tambets, Kristiina; Bergström, Anders; Xue, Yali; Warmuth, Vera; Friend, Andrew D.; Singarayer, Joy; Valdes, Paul; Balloux, Francois; Leboreiro, Ilán; Vera, Jose Luis; Rangel-Villalobos, Hector; Pettener, Davide; Luiselli, Donata; Davis, Loren G.; Heyer, Evelyne; Zollikofer, Christoph P E; Ponce De León, Marcia S.; Smith, Colin I.; Grimes, Vaughan; Pike, Kelly Anne; Deal, Michael; Fuller, Benjamin T.; Arriaza, Bernardo; Standen, Vivien; Luz, Maria F.; Ricaut, Francois; Guidon, Niede; Osipova, Ludmila; Voevoda, Mikhail I.; Posukh, Olga L.; Balanovsky, Oleg; Lavryashina, Maria; Bogunov, Yuri; Khusnutdinova, Elza; Gubina, Marina; Balanovska, Elena; Fedorova, Sardana; Litvinov, Sergey; Malyarchuk, Boris; Derenko, Miroslava; Mosher, M. J.; Archer, David; Cybulski, Jerome
Abstract:
How and when the Americas were populated remains contentious. Using ancient and modern genome-wide data, we found that the ancestors of all present-day Native Americans, including Athabascans and Amerindians, entered the Americas as a single migration wave from Siberia no earlier than 23 thousand years ago (ka) and after no more than an 8000-year isolation period in Beringia. After their arrival to the Americas, ancestral Native Americans diversified into two basal genetic branches around 13 ka, one that is now dispersed across North and South America and the other restricted to North America. Subsequent gene flow resulted in some Native Americans sharing ancestry with present-day East Asians (including Siberians) and, more distantly, Australo-Melanesians. Putative "Paleoamerican" relict populations, including the historical Mexican Pericúes and South American Fuego-Patagonians, are not directly related to modern Australo-Melanesians as suggested by the Paleoamerican Model. © 2015, American Association for the Advancement of Science. All rights reserved.
KAUST Department:
Integrative Systems Biology Lab
Citation:
Raghavan M, Steinrucken M, Harris K, Schiffels S, Rasmussen S, et al. (2015) Genomic evidence for the Pleistocene and recent population history of Native Americans. Science 349: aab3884–aab3884. Available: http://dx.doi.org/10.1126/science.aab3884.
Publisher:
American Association for the Advancement of Science (AAAS)
Journal:
Science
Issue Date:
21-Jul-2015
DOI:
10.1126/science.aab3884
PubMed ID:
26198033
Type:
Article
ISSN:
0036-8075; 1095-9203
Sponsors:
098051, European Research Council; European Research Council; 13-06-00670, RFBR, European Research Council; 14-0400725, RFBR, European Research Council; 14-06-00384, RFBR, European Research Council; 261213, ERC, European Research Council; 2R01HG003229-09, NIH, European Research Council; BB/H005854/1, BBSRC, European Research Council; BCS-1025139, NSF, European Research Council; FT0992258, ARC, European Research Council; CONACYT, European Research Council; ERC, European Research Council; DMS-1201234, NSF, European Research Council; ERC-2011-AdG 295733, ERC, European Research Council; R01-AI17892, NIH, European Research Council; R01-GM094402, NIH, European Research Council
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorRaghavan, Maanasaen
dc.contributor.authorSteinrücken, Matthiasen
dc.contributor.authorHarris, Kelleyen
dc.contributor.authorSchiffels, Stephanen
dc.contributor.authorRasmussen, Simonen
dc.contributor.authorDeGiorgio, Michaelen
dc.contributor.authorAlbrechtsen, Andersen
dc.contributor.authorValdiosera, Cristinaen
dc.contributor.authorÁvila-Arcos, María C.en
dc.contributor.authorMalaspinas, Anna Sapfoen
dc.contributor.authorEriksson, Andersen
dc.contributor.authorMoltke, Idaen
dc.contributor.authorMetspalu, Maiten
dc.contributor.authorHomburger, Julian R.en
dc.contributor.authorWall, Jeffen
dc.contributor.authorCornejo, Omar E.en
dc.contributor.authorMoreno-Mayar, J. Víctoren
dc.contributor.authorKorneliussen, Thorfinn S.en
dc.contributor.authorPierre, Traceyen
dc.contributor.authorRasmussen, Mortenen
dc.contributor.authorCampos, Paula F.en
dc.contributor.authorDe Barros Damgaard, Peteren
dc.contributor.authorAllentoft, Morten E.en
dc.contributor.authorLindo, Johnen
dc.contributor.authorMetspalu, Eneen
dc.contributor.authorRodríguez-Varela, Ricardoen
dc.contributor.authorMansilla, Josefinaen
dc.contributor.authorHenrickson, Celesteen
dc.contributor.authorSeguin-Orlando, Andaineen
dc.contributor.authorMalmstöm, Helenaen
dc.contributor.authorStafford, Thomasen
dc.contributor.authorShringarpure, Suyash S.en
dc.contributor.authorMoreno-Estrada, Andrésen
dc.contributor.authorKarmin, Monikaen
dc.contributor.authorTambets, Kristiinaen
dc.contributor.authorBergström, Andersen
dc.contributor.authorXue, Yalien
dc.contributor.authorWarmuth, Veraen
dc.contributor.authorFriend, Andrew D.en
dc.contributor.authorSingarayer, Joyen
dc.contributor.authorValdes, Paulen
dc.contributor.authorBalloux, Francoisen
dc.contributor.authorLeboreiro, Ilánen
dc.contributor.authorVera, Jose Luisen
dc.contributor.authorRangel-Villalobos, Hectoren
dc.contributor.authorPettener, Davideen
dc.contributor.authorLuiselli, Donataen
dc.contributor.authorDavis, Loren G.en
dc.contributor.authorHeyer, Evelyneen
dc.contributor.authorZollikofer, Christoph P Een
dc.contributor.authorPonce De León, Marcia S.en
dc.contributor.authorSmith, Colin I.en
dc.contributor.authorGrimes, Vaughanen
dc.contributor.authorPike, Kelly Anneen
dc.contributor.authorDeal, Michaelen
dc.contributor.authorFuller, Benjamin T.en
dc.contributor.authorArriaza, Bernardoen
dc.contributor.authorStanden, Vivienen
dc.contributor.authorLuz, Maria F.en
dc.contributor.authorRicaut, Francoisen
dc.contributor.authorGuidon, Niedeen
dc.contributor.authorOsipova, Ludmilaen
dc.contributor.authorVoevoda, Mikhail I.en
dc.contributor.authorPosukh, Olga L.en
dc.contributor.authorBalanovsky, Olegen
dc.contributor.authorLavryashina, Mariaen
dc.contributor.authorBogunov, Yurien
dc.contributor.authorKhusnutdinova, Elzaen
dc.contributor.authorGubina, Marinaen
dc.contributor.authorBalanovska, Elenaen
dc.contributor.authorFedorova, Sardanaen
dc.contributor.authorLitvinov, Sergeyen
dc.contributor.authorMalyarchuk, Borisen
dc.contributor.authorDerenko, Miroslavaen
dc.contributor.authorMosher, M. J.en
dc.contributor.authorArcher, Daviden
dc.contributor.authorCybulski, Jeromeen
dc.date.accessioned2016-01-19T13:22:17Zen
dc.date.available2016-01-19T13:22:17Zen
dc.date.issued2015-07-21en
dc.identifier.citationRaghavan M, Steinrucken M, Harris K, Schiffels S, Rasmussen S, et al. (2015) Genomic evidence for the Pleistocene and recent population history of Native Americans. Science 349: aab3884–aab3884. Available: http://dx.doi.org/10.1126/science.aab3884.en
dc.identifier.issn0036-8075en
dc.identifier.issn1095-9203en
dc.identifier.pmid26198033en
dc.identifier.doi10.1126/science.aab3884en
dc.identifier.urihttp://hdl.handle.net/10754/594129en
dc.description.abstractHow and when the Americas were populated remains contentious. Using ancient and modern genome-wide data, we found that the ancestors of all present-day Native Americans, including Athabascans and Amerindians, entered the Americas as a single migration wave from Siberia no earlier than 23 thousand years ago (ka) and after no more than an 8000-year isolation period in Beringia. After their arrival to the Americas, ancestral Native Americans diversified into two basal genetic branches around 13 ka, one that is now dispersed across North and South America and the other restricted to North America. Subsequent gene flow resulted in some Native Americans sharing ancestry with present-day East Asians (including Siberians) and, more distantly, Australo-Melanesians. Putative "Paleoamerican" relict populations, including the historical Mexican Pericúes and South American Fuego-Patagonians, are not directly related to modern Australo-Melanesians as suggested by the Paleoamerican Model. © 2015, American Association for the Advancement of Science. All rights reserved.en
dc.description.sponsorship098051, European Research Council; European Research Council; 13-06-00670, RFBR, European Research Council; 14-0400725, RFBR, European Research Council; 14-06-00384, RFBR, European Research Council; 261213, ERC, European Research Council; 2R01HG003229-09, NIH, European Research Council; BB/H005854/1, BBSRC, European Research Council; BCS-1025139, NSF, European Research Council; FT0992258, ARC, European Research Council; CONACYT, European Research Council; ERC, European Research Council; DMS-1201234, NSF, European Research Council; ERC-2011-AdG 295733, ERC, European Research Council; R01-AI17892, NIH, European Research Council; R01-GM094402, NIH, European Research Councilen
dc.publisherAmerican Association for the Advancement of Science (AAAS)en
dc.titleGenomic evidence for the Pleistocene and recent population history of Native Americansen
dc.typeArticleen
dc.contributor.departmentIntegrative Systems Biology Laben
dc.identifier.journalScienceen
dc.contributor.institutionCentre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5-7, Copenhagen, Denmarken
dc.contributor.institutionComputer Science Division, University of California, Berkeley, Berkeley, CA, United Statesen
dc.contributor.institutionDepartment of Statistics, University of California, Berkeley, Berkeley, CA, United Statesen
dc.contributor.institutionDepartment of Biostatistics and Epidemiology, University of Massachusetts, Amherst, MA, United Statesen
dc.contributor.institutionDepartment of Mathematics, University of California, Berkeley, Berkeley, CA, United Statesen
dc.contributor.institutionWellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdomen
dc.contributor.institutionCenter for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Kemitorvet, Building 208, Kongens Lyngby, Denmarken
dc.contributor.institutionDepartmentof Biology and Statistics, Pennsylvania State University, 502 Wartik Laboratory, University Park, PA, United Statesen
dc.contributor.institutionBioinformatics Centre, Department of Biology, University of Copenhagen, Ole Maaløes Vej 5, Copenhagen, Denmarken
dc.contributor.institutionDepartment of Archaeology and History, La Trobe University, Melbourne, VIC, Australiaen
dc.contributor.institutionDepartment of Genetics, School of Medicine, Stanford University, 300 Pasteur Drive, Lane Building, Room L331, Stanford, CA, United Statesen
dc.contributor.institutionDepartment of Zoology, University of Cambridge, Downing Street, Cambridge, United Kingdomen
dc.contributor.institutionEstonian Biocentre, Evolutionary Biology Group, Tartu, Estoniaen
dc.contributor.institutionDepartment of Evolutionary Biology, University of Tartu, Tartu, Estoniaen
dc.contributor.institutionInstitute for Human Genetics, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA, United Statesen
dc.contributor.institutionSchool of Biological Sciences, Washington State University, Post Office Box 644236, Heald 429, Pullman, WA, United Statesen
dc.contributor.institutionCentro de Investigación en Ciencias del Mar y Limnología/Centro Interdisciplinar de Investigação Marinha e Ambiental, Centro Interdisciplinar de Investigação Marinha e Ambiental, Universidade do Porto, Rua dos Bragas 289, Porto, Portugalen
dc.contributor.institutionDepartment of Anthropology, University of Illinois at Urbana-Champaign, 607 S. Mathews Avenue, Urbana, IL, United Statesen
dc.contributor.institutionCentro Mixto, Universidad Complutense de Madrid, Instituto de Salud Carlos III de Evolución y Comportamiento Humano, Madrid, Spainen
dc.contributor.institutionInstituto Nacional de Antropología e Historia, Moneda 13, Centro, Cuauhtémoc, Mexico City, Mexicoen
dc.contributor.institutionUniversity of Utah, Department of Anthropology, 270 S 1400 E, Salt Lake City, UT, United Statesen
dc.contributor.institutionDepartment of Evolutionary Biology and Science for Life Laboratory, Uppsala University, Norbyvägen 18D, Uppsala, Swedenen
dc.contributor.institutionAcceleration Mass Spectrometry 14C Dating Centre, Department of Physics and Astronomy, Aarhus University, Ny Munkegade 120, Aarhus, Denmarken
dc.contributor.institutionLaboratorio Nacional de Genómica para la Biodiversidad (LANGEBIO), Centro de Investigación y de Estudios Avanzados, Irapuato, Guanajuato, Mexicoen
dc.contributor.institutionGenetics Institute, University College London, Gower Street, London, United Kingdomen
dc.contributor.institutionEvolutionsbiologiskt Centrum, Norbyvägen 18D, Uppsala, Swedenen
dc.contributor.institutionDepartment of Geography, University of Cambridge, Downing Place, Cambridge, United Kingdomen
dc.contributor.institutionCentre for Past Climate Change, Department of Meteorology, University of Reading, Earley Gate, Post Office Box 243, Reading, United Kingdomen
dc.contributor.institutionSchool of Geographical Sciences, University Road, Clifton, Bristol, United Kingdomen
dc.contributor.institutionEscuela Nacional de Antropología e Historia, Periférico Sur y Zapote s/n Colonia Isidro Fabela, Tlalpan, Isidro Fabela, Mexico City, Mexicoen
dc.contributor.institutionInstituto de Investigación en Genética Molecular, Universidad de Guadalajara, Ocotlán, Mexicoen
dc.contributor.institutionDipartimento di Scienze Biologiche, Geologiche e Ambientali (BiGeA), Università di Bologna, Via Selmi 3, Bologna, Italyen
dc.contributor.institutionDepartment of Anthropology, Oregon State University, 238 Waldo Hall, Corvallis, OR, United Statesen
dc.contributor.institutionMuseum National d'Histoire Naturelle, CNRS, Université Paris 7 Diderot, Paris, Franceen
dc.contributor.institutionAnthropological Institute and Museum, University of Zürich, Winterthurerstrasse 190, Zürich, Switzerlanden
dc.contributor.institutionDepartment of Archaeology, Memorial University, Queen's College, 210 Prince Philip Drive, St. John's, Newfoundland, Canadaen
dc.contributor.institutionDepartment of Human Evolution, Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, Leipzig, Germanyen
dc.contributor.institutionDepartment of Earth System Science, University of California, Irvine, Keck Carbon Cycle Accelerator Mass Spectrometry Group, B321 Croul Hall, Irvine, CA, United Statesen
dc.contributor.institutionInstituto de Alta Investigación, Universidad de Tarapacá, 18 de Septiembre 2222, Carsilla 6-D Arica, Chileen
dc.contributor.institutionDepartamento de Antropologia, Universidad de Tarapacá, 18 de Septiembre 2222, Carsilla 6-D Arica, Chileen
dc.contributor.institutionFundação Museu do Homem Americano, Centro Cultural Sérgio Motta, Campestre, Sao Raimundo Nonato, Brazilen
dc.contributor.institutionLaboratoire d'Anthropologie Moléculaire et Imagérie de Synthèse UMR-5288, CNRS, Université de Toulouse, Toulouse, Franceen
dc.contributor.institutionInstitute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Prospekt Lavrentyeva 10, Novosibirsk, Russian Federationen
dc.contributor.institutionNovosibirsk State University, 2 Pirogova Street, Novosibirsk, Russian Federationen
dc.contributor.institutionInstitute of Internal Medicine, Siberian Branch of RAS, 175/1 ul. B. Bogatkova, Novosibirsk, Russian Federationen
dc.contributor.institutionNovosibirsk State University, Laboratory of Molecular Epidemiology and Bioinformatics, Novosibirsk, Russian Federationen
dc.contributor.institutionVavilov Institute of General Genetics, Gubkina 3, Moscow, Russian Federationen
dc.contributor.institutionResearch Centre for Medical Genetics, Moskvorechie 1, Moscow, Russian Federationen
dc.contributor.institutionKemerovo State University, Krasnaya 3, Kemerovo, Russian Federationen
dc.contributor.institutionInstitute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Sciences, Prospekt Oktyabrya 71, Ufa, Russian Federationen
dc.contributor.institutionDepartment of Genetics and Fundamental Medicine, Bashkir State University, Zaki Validi 32, Ufa, Russian Federationen
dc.contributor.institutionDepartment of Molecular Genetics, Yakut Scientific Centre of Complex Medical Problems, Sergelyahskoe Shosse 4, Yakutsk, Russian Federationen
dc.contributor.institutionLaboratory of Molecular Biology, Institute of Natural Sciences, M. K. Ammosov North-Eastern Federal University, Yakutsk, Russian Federationen
dc.contributor.institutionInstitute of Biological Problems of the North, Russian Academy of Sciences, Portovaya Street 18, Magadan, Russian Federationen
dc.contributor.institutionDepartment of Anthropology, Western Washington University, Bellingham, WA, United Statesen
dc.contributor.institutionDepartment of Anthropology, Northwest Community College, 353 Fifth Street, 65Prince RupertBC, Canadaen
dc.contributor.institutionCanadian Museum of History, 100 Rue Laurier, Gatineau, QC, Canadaen
dc.contributor.institutionUniversity of Western Ontario, London, ON, Canadaen
dc.contributor.institutionSimon Fraser University, Burnaby, BC, Canadaen
dc.contributor.institutionMetlakatla Treaty Office, Post Office Box 224, Prince Rupert, BC, Canadaen
dc.contributor.institutionSealaska Heritage Institute, 105 S. Seward Street, Juneau, AK, United Statesen
dc.contributor.institutionDepartment of Structural Biology, Stanford University School of Medicine, D100 Fairchild Science Building, Stanford, CA, United Statesen
dc.contributor.institutionDepartment of Anthropology, Washington State University, Pullman, WA, United Statesen
dc.contributor.institutionDivision of Biological Anthropology, University of Cambridge, Henry Wellcome Building, Fitzwilliam Street, Cambridge, United Kingdomen
dc.contributor.institutionDepartment of Medicine, University of Cambridge, Medical Research Council Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge, United Kingdomen
dc.contributor.institutionLaboratory of Biological Anthropology, University of Kansas, 1415 Jayhawk Boulevard, 622 Fraser Hall, Lawrence, KS, United Statesen
dc.contributor.institutionKSMolecular Anthropology Laboratory, Department of Anthropology, University of California, One Shields Avenue, Davis, United Statesen
dc.contributor.institutionCenter for the Study of the First Americans, Texas A and M University, College Station, United Statesen
dc.contributor.institutionDepartment of Anthropology, Texas A and M University, College Station, TX, United Statesen
dc.contributor.institutionDepartment of Geography, Texas A and M University, College Station, TX, United Statesen
dc.contributor.institutionSanta Barbara Museum of Natural History, 2559 Puesta del Sol, Santa Barbara, CA, United Statesen
dc.contributor.institutionCarle R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, United Statesen
dc.contributor.institutionDepartment of Anthropology, Southern Methodist University, Dallas, TX, United Statesen
dc.contributor.institutionDepartment of Integrative Biology, University of California, 3060 Valley Life Sciences Building 3140, Berkeley, CA, United Statesen
kaust.authorEriksson, Andersen

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