Glycosylation in HIV-1 envelope glycoprotein and its biological implications

Handle URI:
http://hdl.handle.net/10754/594120
Title:
Glycosylation in HIV-1 envelope glycoprotein and its biological implications
Authors:
Ho, Yung Shwen; Saksena, Nitin K.
Abstract:
Glycosylation of HIV-1 envelope proteins (Env gp120/gp41) plays a vital role in viral evasion from the host immune response, which occurs through the masking of key neutralization epitopes and the presentation of the Env glycosylation as 'self' to the host immune system. Env glycosylation is generally conserved, yet its continual evolution plays an important role in modulating viral infectivity and Env immunogenicity. Thus, it is believed that Env glycosylation, which is a vital part of the HIV-1 architecture, also controls intra- and inter-clade genetic variations. Discerning intra- and inter-clade glycosylation variations could therefore yield important information for understanding the molecular and biological differences between HIV clades and may assist in effectively designing Env-based immunogens and in clearly understanding HIV vaccines. This review provides an in-depth perspective of various aspects of Env glycosylation in the context of HIV-1 pathogenesis. © 2013 Future Medicine Ltd.
KAUST Department:
Biological and Environmental Sciences and Engineering (BESE) Division; Computational Bioscience Research Center (CBRC)
Citation:
Ho YS, Saksena NK (2013) Glycosylation in HIV-1 envelope glycoprotein and its biological implications. Future Virology 8: 783–800. Available: http://dx.doi.org/10.2217/fvl.13.64.
Publisher:
Future Medicine Ltd
Journal:
Future Virology
Issue Date:
Aug-2013
DOI:
10.2217/fvl.13.64
Type:
Article
ISSN:
1746-0794; 1746-0808
Appears in Collections:
Articles; Computational Bioscience Research Center (CBRC); Biological and Environmental Sciences and Engineering (BESE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorHo, Yung Shwenen
dc.contributor.authorSaksena, Nitin K.en
dc.date.accessioned2016-01-19T13:22:04Zen
dc.date.available2016-01-19T13:22:04Zen
dc.date.issued2013-08en
dc.identifier.citationHo YS, Saksena NK (2013) Glycosylation in HIV-1 envelope glycoprotein and its biological implications. Future Virology 8: 783–800. Available: http://dx.doi.org/10.2217/fvl.13.64.en
dc.identifier.issn1746-0794en
dc.identifier.issn1746-0808en
dc.identifier.doi10.2217/fvl.13.64en
dc.identifier.urihttp://hdl.handle.net/10754/594120en
dc.description.abstractGlycosylation of HIV-1 envelope proteins (Env gp120/gp41) plays a vital role in viral evasion from the host immune response, which occurs through the masking of key neutralization epitopes and the presentation of the Env glycosylation as 'self' to the host immune system. Env glycosylation is generally conserved, yet its continual evolution plays an important role in modulating viral infectivity and Env immunogenicity. Thus, it is believed that Env glycosylation, which is a vital part of the HIV-1 architecture, also controls intra- and inter-clade genetic variations. Discerning intra- and inter-clade glycosylation variations could therefore yield important information for understanding the molecular and biological differences between HIV clades and may assist in effectively designing Env-based immunogens and in clearly understanding HIV vaccines. This review provides an in-depth perspective of various aspects of Env glycosylation in the context of HIV-1 pathogenesis. © 2013 Future Medicine Ltd.en
dc.publisherFuture Medicine Ltden
dc.subjectHIVen
dc.subjectHIV evolutionen
dc.subjectN-linked glycosylationen
dc.subjectO-linked glycosylationen
dc.titleGlycosylation in HIV-1 envelope glycoprotein and its biological implicationsen
dc.typeArticleen
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Divisionen
dc.contributor.departmentComputational Bioscience Research Center (CBRC)en
dc.identifier.journalFuture Virologyen
dc.contributor.institutionCenter for Virus Research, Westmead Millennium Instiute and Westmead Hospital, University of Sydney, Westmead, Sydney, NSW 2145, Australiaen
kaust.authorHo, Yung Shwenen
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