Cell-free nucleic acids as noninvasive biomarkers for colorectal cancer detection

Handle URI:
http://hdl.handle.net/10754/593266
Title:
Cell-free nucleic acids as noninvasive biomarkers for colorectal cancer detection
Authors:
Mansour, Hicham
Abstract:
Cell-free nucleic acids (CFNA) have been reported by several authors in blood, stool, and urine of patients with colorectal cancer (CRC). These genetic biomarkers can be an indication of neoplastic colorectal epithelial cells, and can thus potentially be used as noninvasive tests for the detection of the disease in CRC patients and monitor their staging, without the need to use heavier and invasive tools. In a number of test-trials, these genetic tests have shown the advantage of non-invasiveness, making them well accepted by most of the patients, without major side effects. They have also shown a promising sensitivity and specificity in the detection of malignant and premalignant neoplasms. Moreover, costs for performing such tests are very low. Several studies reported and confirmed the proof of the principle for these genetic tests for screening, diagnosis, and prognosis; the main challenge of translating this approach from research to clinical laboratory is the validation from large and long-term randomized trials to prove sustainable high sensitivity and specificity. In this paper, we present a review on the noninvasive genetics biomarkers for CRC detection described in the literature and the challenges that can be encountered for validation processes.
KAUST Department:
Biosciences Core Lab
Citation:
Cell-free nucleic acids as noninvasive biomarkers for colorectal cancer detection 2014, 5 Frontiers in Genetics
Publisher:
Frontiers Media SA
Journal:
Frontiers in Genetics
Issue Date:
27-Aug-2014
DOI:
10.3389/fgene.2014.00182
Type:
Article
ISSN:
1664-8021
Additional Links:
http://journal.frontiersin.org/article/10.3389/fgene.2014.00182/abstract
Appears in Collections:
Articles; Biosciences Core Lab

Full metadata record

DC FieldValue Language
dc.contributor.authorMansour, Hichamen
dc.date.accessioned2016-01-11T12:58:35Zen
dc.date.available2016-01-11T12:58:35Zen
dc.date.issued2014-08-27en
dc.identifier.citationCell-free nucleic acids as noninvasive biomarkers for colorectal cancer detection 2014, 5 Frontiers in Geneticsen
dc.identifier.issn1664-8021en
dc.identifier.doi10.3389/fgene.2014.00182en
dc.identifier.urihttp://hdl.handle.net/10754/593266en
dc.description.abstractCell-free nucleic acids (CFNA) have been reported by several authors in blood, stool, and urine of patients with colorectal cancer (CRC). These genetic biomarkers can be an indication of neoplastic colorectal epithelial cells, and can thus potentially be used as noninvasive tests for the detection of the disease in CRC patients and monitor their staging, without the need to use heavier and invasive tools. In a number of test-trials, these genetic tests have shown the advantage of non-invasiveness, making them well accepted by most of the patients, without major side effects. They have also shown a promising sensitivity and specificity in the detection of malignant and premalignant neoplasms. Moreover, costs for performing such tests are very low. Several studies reported and confirmed the proof of the principle for these genetic tests for screening, diagnosis, and prognosis; the main challenge of translating this approach from research to clinical laboratory is the validation from large and long-term randomized trials to prove sustainable high sensitivity and specificity. In this paper, we present a review on the noninvasive genetics biomarkers for CRC detection described in the literature and the challenges that can be encountered for validation processes.en
dc.language.isoenen
dc.publisherFrontiers Media SAen
dc.relation.urlhttp://journal.frontiersin.org/article/10.3389/fgene.2014.00182/abstracten
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en
dc.subjectcolorectal canceren
dc.subjectcell-free nucleic acidsen
dc.subjectCFNAen
dc.subjectbiomarkersen
dc.subjectnoninvasive testsen
dc.subjectmiRNAsen
dc.subjectDNA mutationen
dc.subjectDNA methylationen
dc.titleCell-free nucleic acids as noninvasive biomarkers for colorectal cancer detectionen
dc.typeArticleen
dc.contributor.departmentBiosciences Core Laben
dc.identifier.journalFrontiers in Geneticsen
dc.eprint.versionPublisher's Version/PDFen
dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)en
kaust.authorMansour, Hichamen
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