A New Outlook on Mental Illnesses: Glial Involvement Beyond the Glue

Handle URI:
http://hdl.handle.net/10754/592819
Title:
A New Outlook on Mental Illnesses: Glial Involvement Beyond the Glue
Authors:
Elsayed, Maha; Magistretti, Pierre J. ( 0000-0002-6678-320X )
Abstract:
Mental illnesses have long been perceived as the exclusive consequence of abnormalities in neuronal functioning. Until recently, the role of glial cells in the pathophysiology of mental diseases has largely been overlooked. However recently, multiple lines of evidence suggest more diverse and significant functions of glia with behavior-altering effects. The newly ascribed roles of astrocytes, oligodendrocytes and microglia have led to their examination in brain pathology and mental illnesses. Indeed, abnormalities in glial function, structure and density have been observed in postmortem brain studies of subjects diagnosed with mental illnesses. In this review, we discuss the newly identified functions of glia and highlight the findings of glial abnormalities in psychiatric disorders. We discuss these preclinical and clinical findings implicating the involvement of glial cells in mental illnesses with the perspective that these cells may represent a new target for treatment.
KAUST Department:
Biological and Environmental Sciences and Engineering (BESE) Division
Citation:
A New Outlook on Mental Illnesses: Glial Involvement Beyond the Glue 2015, 9 Frontiers in Cellular Neuroscience
Publisher:
Frontiers Media SA
Journal:
Frontiers in Cellular Neuroscience
Issue Date:
16-Dec-2015
DOI:
10.3389/fncel.2015.00468
Type:
Article
ISSN:
1662-5102
Additional Links:
http://journal.frontiersin.org/article/10.3389/fncel.2015.00468
Appears in Collections:
Articles; Biological and Environmental Sciences and Engineering (BESE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorElsayed, Mahaen
dc.contributor.authorMagistretti, Pierre J.en
dc.date.accessioned2016-01-05T07:35:03Zen
dc.date.available2016-01-05T07:35:03Zen
dc.date.issued2015-12-16en
dc.identifier.citationA New Outlook on Mental Illnesses: Glial Involvement Beyond the Glue 2015, 9 Frontiers in Cellular Neuroscienceen
dc.identifier.issn1662-5102en
dc.identifier.doi10.3389/fncel.2015.00468en
dc.identifier.urihttp://hdl.handle.net/10754/592819en
dc.description.abstractMental illnesses have long been perceived as the exclusive consequence of abnormalities in neuronal functioning. Until recently, the role of glial cells in the pathophysiology of mental diseases has largely been overlooked. However recently, multiple lines of evidence suggest more diverse and significant functions of glia with behavior-altering effects. The newly ascribed roles of astrocytes, oligodendrocytes and microglia have led to their examination in brain pathology and mental illnesses. Indeed, abnormalities in glial function, structure and density have been observed in postmortem brain studies of subjects diagnosed with mental illnesses. In this review, we discuss the newly identified functions of glia and highlight the findings of glial abnormalities in psychiatric disorders. We discuss these preclinical and clinical findings implicating the involvement of glial cells in mental illnesses with the perspective that these cells may represent a new target for treatment.en
dc.language.isoenen
dc.publisherFrontiers Media SAen
dc.relation.urlhttp://journal.frontiersin.org/article/10.3389/fncel.2015.00468en
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en
dc.subjectpsychiatric disorderen
dc.subjectgliaen
dc.subjectastrocyteen
dc.subjectoligodendrocyteen
dc.subjectmicrogliaen
dc.subjectNG2 gliaen
dc.subjectmooden
dc.subjectcognitionen
dc.titleA New Outlook on Mental Illnesses: Glial Involvement Beyond the Glueen
dc.typeArticleen
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Divisionen
dc.identifier.journalFrontiers in Cellular Neuroscienceen
dc.eprint.versionPublisher's Version/PDFen
dc.contributor.institutionLaboratory of Neuroenergetics and Cellular Dynamics, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerlanden
dc.contributor.institutionDepartment of Psychiatry, Center for Psychiatric Neurosciences, University of Lausanne, Lausanne, Switzerlanden
dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)en
kaust.authorMagistretti, Pierre J.en
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