Diversity of extracellular proteins during the transition from the ‘proto-apicomplexan’ alveolates to the apicomplexan obligate parasites

Handle URI:
http://hdl.handle.net/10754/583074
Title:
Diversity of extracellular proteins during the transition from the ‘proto-apicomplexan’ alveolates to the apicomplexan obligate parasites
Authors:
Templeton, Thomas J.; Pain, Arnab ( 0000-0002-1755-2819 )
Abstract:
The recent completion of high-coverage draft genome sequences for several alveolate protozoans – namely, the chromerids, Chromera velia and Vitrella brassicaformis ; the perkinsid Perkinsus marinus ; the apicomplexan, Gregarina niphandrodes , as well as high coverage transcriptome sequence information for several colpodellids, allows for new genome-scale comparisons across a rich landscape of apicomplexans and other alveolates. Genome annotations can now be used to help interpret fine ultrastructure and cell biology, and guide new studies to describe a variety of alveolate life strategies, such as symbiosis or free living, predation, and obligate intracellular parasitism, as well to provide foundations to dissect the evolutionary transitions between these niches. This review focuses on the attempt to identify extracellular proteins which might mediate the physical interface of cell–cell interactions within the above life strategies, aided by annotation of the repertoires of predicted surface and secreted proteins encoded within alveolate genomes. In particular, we discuss what descriptions of the predicted extracellular proteomes reveal regarding a hypothetical last common ancestor of a pre-apicomplexan alveolate – guided by ultrastructure, life strategies and phylogenetic relationships – in an attempt to understand the evolution of obligate parasitism in apicomplexans.
KAUST Department:
Pathogen Genomics Laboratory; Biological and Environmental Sciences and Engineering (BESE) Division
Citation:
Diversity of extracellular proteins during the transition from the ‘proto-apicomplexan’ alveolates to the apicomplexan obligate parasites 2015:1 Parasitology
Publisher:
Cambridge University Press (CUP)
Journal:
Parasitology
Issue Date:
20-Nov-2015
DOI:
10.1017/S0031182015001213
Type:
Article
ISSN:
0031-1820; 1469-8161
Additional Links:
http://www.journals.cambridge.org/abstract_S0031182015001213
Appears in Collections:
Articles; Biological and Environmental Sciences and Engineering (BESE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorTempleton, Thomas J.en
dc.contributor.authorPain, Arnaben
dc.date.accessioned2015-12-01T13:42:27Zen
dc.date.available2015-12-01T13:42:27Zen
dc.date.issued2015-11-20en
dc.identifier.citationDiversity of extracellular proteins during the transition from the ‘proto-apicomplexan’ alveolates to the apicomplexan obligate parasites 2015:1 Parasitologyen
dc.identifier.issn0031-1820en
dc.identifier.issn1469-8161en
dc.identifier.doi10.1017/S0031182015001213en
dc.identifier.urihttp://hdl.handle.net/10754/583074en
dc.description.abstractThe recent completion of high-coverage draft genome sequences for several alveolate protozoans – namely, the chromerids, Chromera velia and Vitrella brassicaformis ; the perkinsid Perkinsus marinus ; the apicomplexan, Gregarina niphandrodes , as well as high coverage transcriptome sequence information for several colpodellids, allows for new genome-scale comparisons across a rich landscape of apicomplexans and other alveolates. Genome annotations can now be used to help interpret fine ultrastructure and cell biology, and guide new studies to describe a variety of alveolate life strategies, such as symbiosis or free living, predation, and obligate intracellular parasitism, as well to provide foundations to dissect the evolutionary transitions between these niches. This review focuses on the attempt to identify extracellular proteins which might mediate the physical interface of cell–cell interactions within the above life strategies, aided by annotation of the repertoires of predicted surface and secreted proteins encoded within alveolate genomes. In particular, we discuss what descriptions of the predicted extracellular proteomes reveal regarding a hypothetical last common ancestor of a pre-apicomplexan alveolate – guided by ultrastructure, life strategies and phylogenetic relationships – in an attempt to understand the evolution of obligate parasitism in apicomplexans.en
dc.language.isoenen
dc.publisherCambridge University Press (CUP)en
dc.relation.urlhttp://www.journals.cambridge.org/abstract_S0031182015001213en
dc.rightsArchived with thanks to Parasitology. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.subjectApicomplexaen
dc.subjectChromeraen
dc.subjectPlasmodiumen
dc.subjectColpodellaen
dc.subjectVitrellaen
dc.subjectAlveolataen
dc.subjectToxoplasmaen
dc.subjectPerkinsusen
dc.subjectCryptosporidiumen
dc.subjectGregarinaen
dc.titleDiversity of extracellular proteins during the transition from the ‘proto-apicomplexan’ alveolates to the apicomplexan obligate parasitesen
dc.typeArticleen
dc.contributor.departmentPathogen Genomics Laboratoryen
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Divisionen
dc.identifier.journalParasitologyen
dc.eprint.versionPublisher's Version/PDFen
dc.contributor.institutionDepartment of Protozoology, Institute of Tropical Medicine (NEKKEN), Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japanen
dc.contributor.institutionDepartment of Microbiology and Immunology, Weill Cornell Medical College, New York 10021, USAen
dc.contributor.institutionGlobal Station for Zoonosis Control, Global Institution for Collaborative Research and Education (GI-CoRE), Hokkaido University, N20 W10 Kita-ku, Sapporo 001-0020, Japanen
dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)en
kaust.authorPain, Arnaben
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