Hollow ZIF-8 Nanoworms from Block Copolymer Templates

Handle URI:
http://hdl.handle.net/10754/581362
Title:
Hollow ZIF-8 Nanoworms from Block Copolymer Templates
Authors:
Yu, Haizhou; Qiu, Xiaoyan; Neelakanda, Pradeep; Deng, Lin ( 0000-0001-8954-5610 ) ; Khashab, Niveen M. ( 0000-0003-2728-0666 ) ; Nunes, Suzana Pereira ( 0000-0002-3669-138X ) ; Peinemann, Klaus-Viktor ( 0000-0003-0309-9598 )
Abstract:
Recently two quite different types of “nano-containers” have been recognized as attractive potential drug carriers; these are wormlike filamenteous micelles (“filomicelles”) on the one hand and metal organic frameworks on the other hand. In this work we combine these two concepts. We report for the first time the manufacturing of metal organic framework nanotubes with a hollow core. These worm-like tubes are about 200 nm thick and several μm long. The preparation is simple: we first produce long and flexible filament-shaped micelles by block copolymer self-assembly. These filomicelles serve as templates to grow a very thin layer of interconnected ZIF-8 crystals on their surface. Finally the block copolymer is removed by solvent extraction and the hollow ZIF-8 nanotubes remain. These ZIF-NTs are surprisingly stable and withstand purification by centrifugation. The synthesis method is straightforward and can easily be applied for other metal organic framework materials. The ZIF-8 NTs exhibit high loading capacity for the model anti cancer drug doxorubicin (DOX) with a pH-triggered release. Hence, a prolonged circulation in the blood stream and a targeted drug release behavior can be expected.
KAUST Department:
Advanced Membranes and Porous Materials Research Center; Biological and Environmental Sciences and Engineering (BESE) Division
Citation:
Hollow ZIF-8 Nanoworms from Block Copolymer Templates 2015, 5:15275 Scientific Reports
Publisher:
Nature Publishing Group
Journal:
Scientific Reports
Issue Date:
16-Oct-2015
DOI:
10.1038/srep15275
Type:
Article
ISSN:
2045-2322
Additional Links:
http://www.nature.com/articles/srep15275
Appears in Collections:
Articles; Advanced Membranes and Porous Materials Research Center; Biological and Environmental Sciences and Engineering (BESE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorYu, Haizhouen
dc.contributor.authorQiu, Xiaoyanen
dc.contributor.authorNeelakanda, Pradeepen
dc.contributor.authorDeng, Linen
dc.contributor.authorKhashab, Niveen M.en
dc.contributor.authorNunes, Suzana Pereiraen
dc.contributor.authorPeinemann, Klaus-Viktoren
dc.date.accessioned2015-10-28T13:46:01Zen
dc.date.available2015-10-28T13:46:01Zen
dc.date.issued2015-10-16en
dc.identifier.citationHollow ZIF-8 Nanoworms from Block Copolymer Templates 2015, 5:15275 Scientific Reportsen
dc.identifier.issn2045-2322en
dc.identifier.doi10.1038/srep15275en
dc.identifier.urihttp://hdl.handle.net/10754/581362en
dc.description.abstractRecently two quite different types of “nano-containers” have been recognized as attractive potential drug carriers; these are wormlike filamenteous micelles (“filomicelles”) on the one hand and metal organic frameworks on the other hand. In this work we combine these two concepts. We report for the first time the manufacturing of metal organic framework nanotubes with a hollow core. These worm-like tubes are about 200 nm thick and several μm long. The preparation is simple: we first produce long and flexible filament-shaped micelles by block copolymer self-assembly. These filomicelles serve as templates to grow a very thin layer of interconnected ZIF-8 crystals on their surface. Finally the block copolymer is removed by solvent extraction and the hollow ZIF-8 nanotubes remain. These ZIF-NTs are surprisingly stable and withstand purification by centrifugation. The synthesis method is straightforward and can easily be applied for other metal organic framework materials. The ZIF-8 NTs exhibit high loading capacity for the model anti cancer drug doxorubicin (DOX) with a pH-triggered release. Hence, a prolonged circulation in the blood stream and a targeted drug release behavior can be expected.en
dc.language.isoenen
dc.publisherNature Publishing Groupen
dc.relation.urlhttp://www.nature.com/articles/srep15275en
dc.rightsThis work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/en
dc.titleHollow ZIF-8 Nanoworms from Block Copolymer Templatesen
dc.typeArticleen
dc.contributor.departmentAdvanced Membranes and Porous Materials Research Centeren
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Divisionen
dc.identifier.journalScientific Reportsen
dc.eprint.versionPublisher's Version/PDFen
dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)en
kaust.authorYu, Haizhouen
kaust.authorQiu, Xiaoyanen
kaust.authorNeelakanda, Pradeepen
kaust.authorDeng, Linen
kaust.authorKhashab, Niveen M.en
kaust.authorNunes, Suzana Pereiraen
kaust.authorPeinemann, Klaus Viktoren
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